Results 61 to 70 of about 58,898 (268)

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source

The genome sequence of the protostome Daphnia pulex encodes respective orthologues of a neurotrophin, a Trk and a p75NTR: Evolution of neurotrophin signaling components and related proteins in the bilateria

BMC Evolutionary Biology, 2009
Background Neurotrophins and their Trk and p75NTR receptors play an important role in the nervous system. To date, neurotrophins, Trk and p75NTR have only been found concomitantly in deuterostomes.
Wilson Karen HS
doaj   +1 more source

Neurotrophin-3-enhanced nerve regeneration selectively improves recovery of muscle fibers expressing myosin heavy chains 2b [PDF]

, 1997
The purpose of this study was to evaluate the effect of neurotrophin 3 (NT-3) enhanced nerve regeneration on the reinnervation of a target muscle. Muscle fibers can be classified according to their mechanical properties and myosin heavy chain (MHC ...
Airaksinen, Averbuch-Heller, Bar, Bertelli, Braun, Burke, Davis, DiStefano, Eriksson, Ernfors, Fex, Fields, Gillespie, Goldspink, Green, Griesbeck, Henderson, Henderson, Hughes, Isaacson, Izumo, Jansson, Karpati, Kato, Kucera, Kucera, Lefebvre, Lewin, Li, Lindsay, Lohof, Maltin, Oakley, Ozaki, Pellegrino, Peter, Pette, Romanul, Salmons, Schantz, Schiaffino, Schnell, Sterne, Tessarollo, Totosy de Zepetnek, Vejsada, Wang, Wong, Wright   +48 more
core   +2 more sources

Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition

Advanced Science, EarlyView.
Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han, June‐Hyun Jeong, Dongjoon Lee, Yujin Jung, Yujin Jin, Eun Sun Jung, Haeng Jun Kim, Woo Youn Kim, Chang‐Han Lee, Inhee Mook‐Jung   +9 more
wiley   +1 more source

Neurotrophin and Trk expression by cells of the human lamina cribrosa following oxygen-glucose deprivation

BMC Neuroscience, 2004
Background Ischemia within the optic nerve head (ONH) may contribute to retinal ganglion cell (RGC) loss in primary open angle glaucoma (POAG). Ischemia has been reported to increase neurotrophin and high affinity Trk receptor expression by CNS neurons ...
Clark Abbot F, Lambert Wendi S, Wordinger Robert J   +2 more
doaj   +1 more source

Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain [PDF]

, 2010
The consumption of flavonoid-rich foods and beverages has been suggested to limit the neurodegeneration associated with a variety of neurological disorders and to prevent or reverse normal or abnormal deteriorations in cognitive performance.
Spencer, Jeremy Paul
core   +1 more source

Monoaminylation in Human Health and Disease: State of the Field, Challenges, and Emerging Directions

Advanced Science, EarlyView.
This review delineates monoaminylation—serotonylation, dopaminylation, and histaminylation—as key post‐translational modifications beyond receptor signaling. It details their catalytic mechanisms, roles in gene expression and protein function, and implications in health and disease, aiming to bridge mechanistic insights with therapeutic potential ...
Yiqi Zhao, Hongli Zhang, Yating Yang, Wei‐Dong Chen, Yan‐Dong Wang   +4 more
wiley   +1 more source

Role of neurotrophic factors in enhancing linear axonal growth of ganglionic sensory neurons in vitro

Neural Regeneration Research, 2020
Neurotrophins play a major role in the regulation of neuronal growth such as neurite sprouting or regeneration in response to nerve injuries. The role of nerve growth factor, neurotrophin-3, and brain-derived neurotrophic factor in maintaining the ...
Michele Fornaro, Alessia Giovannelli, Angelica Foggetti, Luisa Muratori, Stefano Geuna, Giorgia Novajra, Isabelle Perroteau   +6 more
doaj   +1 more source

Neuroprotective mechanism of BNG-1 against focal cerebral ischemia: a neuroimaging and neurotrophin study. [PDF]

PLoS ONE, 2014
BNG-1 is a herb complex used in traditional Chinese medicine to treat stroke. In this study, we attempted to identify the neuroprotective mechanism of BNG-1 by using neuroimaging and neurotrophin analyses of a stroke animal model.
Nai-Fang Chi, Ho-Ling Liu, Jen-Tsung Yang, Jr-Rung Lin, Shu-Li Liao, Bo-Han Peng, Yen-Tung Lee, Tsong-Hai Lee   +7 more
doaj   +1 more source

Neurotrophin-3 modulates noradrenergic neuron function and opiate withdrawal [PDF]

Molecular Psychiatry, 2001
Somatic symptoms and aversion of opiate withdrawal, regulated by noradrenergic signaling, were attenuated in mice with a CNS-wide conditional ablation of neurotrophin-3. This occurred in conjunction with altered cAMP-mediated excitation and reduced upregulation of tyrosine hydroxylase in A6 (locus coeruleus) without loss of neurons.
S, Akbarian, B, Bates, R J, Liu, S L, Skirboll, T, Pejchal, V, Coppola, L D, Sun, G, Fan, J, Kucera, M A, Wilson, L, Tessarollo, B E, Kosofsky, J R, Taylor, M, Bothwell, E J, Nestler, G K, Aghajanian, R, Jaenisch   +16 more
openaire   +2 more sources