Results 221 to 230 of about 14,410 (259)
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Interpericyte tunnelling nanotubes regulate neurovascular coupling
Nature, 2020Signalling between cells of the neurovascular unit, or neurovascular coupling, is essential to match local blood flow with neuronal activity. Pericytes interact with endothelial cells and extend processes that wrap capillaries, covering up to 90% of their surface area1,2. Pericytes are candidates to regulate microcirculatory blood flow because they are
Luis Alarcon-Martinez +8 more
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Neurovascular Coupling During Spreading Depolarizations
2012Injury depolarizations akin to spreading depression of Leão are important in the progression of tissue damage in ischemic stroke, intracranial hemorrhage, and trauma. Much of the research on injury depolarizations has been focused on their origins, electrophysiological mechanisms, and metabolic impact.
Ulrike, Hoffmann, Cenk, Ayata
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Fractional dynamical model for neurovascular coupling
2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2014The neurovascular coupling is a key mechanism linking the neural activity to the hemodynamic behavior. Modeling of this coupling is very important to understand the brain function but it is at the same time very complex due to the complexity of the involved phenomena.
Zehor, Belkhatir +1 more
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Autonomic dysfunction affects cerebral neurovascular coupling
Clinical Autonomic Research, 2011Autonomic failure (AF) affects the peripheral vascular system, but little is known about its influence on cerebrovascular regulation. Patients with familial amyloidotic polyneuropathy (FAP) were studied as a model for AF.Ten mild (FAPm), 10 severe (FAPs) autonomic dysfunction FAP patients, and 15 healthy controls were monitored in supine and sitting ...
Elsa, Azevedo +6 more
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Investigating static nonlinearities in neurovascular coupling
Magnetic Resonance Imaging, 2011Many statistical models of coupling between time changes of the band-limited power of neural signals and functional magnetic resonance imaging Blood Oxygenation Level Dependent (BOLD) signal time changes rely on linear convolution. The effect of nonlinear behaviors in single-trial relationships between neural signals and BOLD responses is rarely tested
Logothetis, Nikos +3 more
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Angiotensin and Neurovascular Coupling: Beyond Hypertension
Microcirculation, 2015AbstractBrain homeostasis is dependent upon the constant perfusion of oxygen and nutrients through CBF. The mechanism responsible to couple CBF to neuronal activity is termed NVC. Ang II, a key player in hypertension, impairs NVC and has been found to be of significant importance in neurodegenerative diseases, such as AD. The presence of Ang II and its
Sherri, Bloch +2 more
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Modeling Secondary Messenger Pathways in Neurovascular Coupling
Bulletin of Mathematical Biology, 2013Neurovascular coupling is the well-documented link between neural stimulation and constriction or dilation of the surrounding vasculature. Glial cells mediate this response via their unique anatomy, which connects neurons to arterioles. It is believed that calcium transients and the release of secondary messengers by these cells influence the vascular ...
Hadfield, James +2 more
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Metabolic Aspects of Neurovascular Coupling
1997In the previous chapter it was demonstrated that functional neuroimaging relies on the coupling of neuronal activity and cerebral blood flow. What is the function of neurovascular coupling? Does it serve to provide a constant glucose or oxygen delivery to brain cells? Does it mainly regulate removal of tissue metabolites such as lactate?
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Optical interrogation of Neurovascular Coupling
Conference on Lasers and Electro-Optics, 2020Brain function is the result of the interaction between neural and vascular networks. We have used optical and electrophysiology techniques to interrogate the coupling between these two networks. Here we report our latest results.
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Neurovascular coupling and retinal oxygenation
Acta Ophthalmologica, 2011AbstractPurpose Luminance flicker stimulation of the photoreceptors is known to increase retinal blood flow. Oxygen supply may be the target of blood flow regulation. Thus, we investigated the oxygen saturation in retinal arterioles and venules along with their diameters in healthy as well as diabetic subjects.Methods 18 patients with non‐proliferative
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