Results 191 to 200 of about 2,153,529 (297)

Associations of Monocyte Glucocerebrosidase with Cognition and Cholinergic Innervation in GBA1 Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background The GBA1 gene encodes the lysosomal enzyme glucocerebrosidase (GCase). Parkinson's disease (PD) patients carrying a GBA1 variant (GBA‐PD) exhibit faster cognitive decline, linked to cholinergic degeneration. Objectives The aim was to investigate whether GCase activity, measured in monocytes, correlates with cognitive dysfunction or ...
Sofie Slingerland, Sygrid van der Zee, Sven C.D. van Ijzendoorn, Anne C. Slomp, Jeffrey M. Boertien, Sanne K. Meles, Arjan Kol, Marie Geerlings, Teus van Laar   +8 more
wiley   +1 more source

Dynamics of neutrophilia at the neurovascular unit arising from repeated pulmonary inflammation. [PDF]

J Neuroinflammation
Chiang W, Li H, Le L, David-Bercholz J, Caceres AI, Ahmad D, Squire E, Stecyk KS, Marrero M, Pereira A, Squire R, Lim C, McGrath JL, Majewska AK, Terrando N, Gelbard HA.   +15 more
europepmc   +1 more source

Gray Matter Microstructure Measured Using Diffusion Imaging as a Biomarker of Severity in Lewy Body Diseases

Movement Disorders, EarlyView.
Abstract Background Despite widespread cortical involvement in Lewy body diseases, conventional gray matter magnetic resonance imaging (MRI) shows limited sensitivity. Diffusion‐weighted MRI‐derived microstructural measures have shown utility in Alzheimer's disease, but their application across the Lewy body disease spectrum remains limited ...
Angeliki Zarkali, Ivelina Dobreva, Naomi Hannaway, Rohan Bhome, George E.C. Thomas, Steffani Carrera, Amanda J. Heslegrave, Elena Veleva, Henrik Zetterberg, Rimona S. Weil   +9 more
wiley   +1 more source

Theranostic Innovative Strategies for Brain Diseases: New Insights on Neurovascular Unit-Associated Pathological Changes in Neurodegenerative Disorders and Aging. [PDF]

Int J Mol Sci
Terribile G, Pedrinazzi M, Frigerio I, Sancini G, Combi R.   +4 more
europepmc   +1 more source

Healthy Dietary Patterns and Risk of Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Although healthy dietary patterns have been suggested to be associated with decreased Parkinson's disease (PD) risk, their protective role remains uncertain. Objective To examine associations between eight dietary patterns and PD risk in two United States (US) cohorts followed for up to 32 years.
Xiao Chen, Hui Chen, Peilu Wang, Michael A. Schwarzschild, Albert Y. Hung, Xiang Gao, Alberto Ascherio, Mario H. Flores‐Torres, Kjetil Bjornevik   +8 more
wiley   +1 more source

Systematic Review of the Huntington's Disease Drug Development Pipeline, 2014 to 2025

Movement Disorders, EarlyView.
Abstract Background In the past decade, significant advances have improved our understanding of the mechanisms underlying HD pathobiology leading to several putative therapeutic targets for HD. Objective The aim was to describe the Huntington's disease (HD) drug development clinical pipeline.
Pavlina Konstantinova, Jenny Townhill, Juliana Bronzova, Viktoria Andreeva, Swati Sathe, Cristina Sampaio   +5 more
wiley   +1 more source

Neurovascular Unit-Derived Extracellular Vesicles as Regulators of Post-Stroke Pathology and Neurorestoration. [PDF]

Biomolecules
Powell B, Chopp M, Zhang Z, Liu X.
europepmc   +1 more source

Voice and Speech in Deep Brain Stimulation in Dystonia: A Retrospective Study, Systematic Review, and Meta‐Analysis

Movement Disorders, EarlyView.
Abstract Background Relatively little is known about voice and speech abnormalities and their changes after deep brain stimulation (DBS) in patients with dystonia. Objective The aim was to determine the incidence of speech abnormalities, including laryngeal dystonia, among patients with dystonia receiving DBS and to characterize their response to this ...
Ian O. Bledsoe, Nutan Sharma, Marta San Luciano, Jill L. Ostrem, Nicole E. Buie, Gaia Arno, Mikayla Day, Kristina Simonyan   +7 more
wiley   +1 more source

Brain neurovascular unit biomarkers: a hypothesis-driven paradigm to advance understanding of post-cardiac arrest cerebral injury. [PDF]

Ann Intensive Care
Bellal M, Goursaud S, Rubio M, Martinaud O, Vivien D, Cheyron DD, Daubin C.   +6 more
europepmc   +1 more source

Deep Brain Stimulation of the Posterior Subthalamic Area and the Subthalamic Nucleus in Tremor‐Dominant Parkinson's Disease: A Randomized, Crossover Trial

Movement Disorders, EarlyView.
Abstract Background The posterior subthalamic area (PSA) is a familiarized target for Parkinson's disease (PD) in the lesioning era and has recently been reconsidered for deep brain stimulation (DBS). Objective The aim of this study was to compare the therapeutic efficacy of PSA versus subthalamic nucleus (STN) DBS in tremor‐dominant Parkinson's ...
Zhengyu Lin, Zhitong Zeng, Yixin Pan, Peng Huang, Yuyan Tan, Chencheng Zhang, Bomin Sun, Dianyou Li   +7 more
wiley   +1 more source