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The Neurovascular Unit in Glaucomatous Neurodegeneration [PDF]
Frontiers in Cell and Developmental Biology, 2020 Glaucoma is a neurodegenerative disease of the visual system and leading cause of blindness worldwide. The disease is associated with sensitivity to intraocular pressure (IOP), which over a large range of magnitudes stresses retinal ganglion cell (RGC) axons as they pass through the optic nerve head in forming the optic projection to the brain. Despite
David J Calkins, Lauren Wareham
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Revisiting the neurovascular unit
Nature Neuroscience, 2021The brain is supplied by an elaborate vascular network that originates extracranially and reaches deep into the brain. The concept of the neurovascular unit provides a useful framework to investigate how neuronal signals regulate nearby microvessels to support the metabolic needs of the brain, but it does not consider the role of larger cerebral ...
Samantha Schaeffer, Costantino Iadecola
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The neurovascular unit - concept review
Acta Physiologica, 2014The cerebral hyperaemia is one of the fundamental mechanisms for the central nervous system homeostasis. Due also to this mechanism, oxygen and nutrients are maintained in satisfactory levels, through vasodilation and vasoconstriction. The brain hyperaemia, or coupling, is accomplished by a group of cells, closely related to each other; called ...
V, Muoio, P B, Persson, M M, Sendeski
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A Human Neurovascular Unit On-a-Chip
2021Protection of the central nervous system (CNS) and cerebral homeostasis depend upon the blood-brain barrier (BBB) functions and permeability. BBB restrictive permeability hinders drug delivery for the treatment of several neurodegenerative diseases and brain tumors.
Lee S. W. L. +5 more
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Neurovascular Unit: a Focus on Pericytes
Molecular Neurobiology, 2012The blood-brain barrier (BBB) is a highly specialized system that controls the exchanges between the blood and the central nervous system (CNS). This barrier shields the CNS from toxic substances in the blood and provides nutrients to CNS, thus playing an essential role in the maintenance of homeostasis. The anatomical basis of the BBB is formed by the
Inês, Sá-Pereira +2 more
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Tauopathies – Focus on Changes at the Neurovascular Unit
Current Alzheimer Research, 2017In the past, the blood-brain barrier (BBB) has been characterized mainly as a layer of endothelial cells forming the vessel/capillary wall of the brain. More recently, the BBB is considered to be a part of a highly dynamic and interactive system called the neurovascular unit (NVU), consisting of vascular cells, glial cells, and neurons.
William Banks +2 more
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Drug Abuse and the Neurovascular Unit
2014Drug abuse continues to create a major international epidemic affecting society. A great majority of past drug abuse research has focused mostly on the mechanisms of addiction and the specific effects of substance use disorders on brain circuits and pathways that modulate reward, motivation, craving, and decision making. Few studies have focused on the
Richard D, Egleton, Thomas, Abbruscato
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The importance of temperature on the neurovascular unit
Early Human Development, 2014Therapeutic hypothermia is the only treatment that has been shown to be of benefit to infant's ≥ 36 weeks of gestation with hypoxic-ischemic encephalopathy. The evidence for the benefit is based on multiple, well-designed randomized clinical trials.
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Circadian Biology and the Neurovascular Unit
Circulation ResearchMammalian physiology and cellular function are subject to significant oscillations over the course of every 24-hour day. It is likely that these daily rhythms will affect function as well as mechanisms of disease in the central nervous system. In this review, we attempt to survey and synthesize emerging studies that investigate how circadian biology ...
Wenlu Li +5 more
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