Results 291 to 300 of about 4,031,569 (323)
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The Neuroscientist, 2023
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), could affect brain structure and function.
D. Kempuraj +8 more
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), could affect brain structure and function.
D. Kempuraj +8 more
semanticscholar +1 more source
Engineering Neurovascular Unit and Blood–Brain Barrier for Ischemic Stroke Modeling
Advanced Healthcare Materials, 2023Ischemic stroke is a primary vascular disease of the central nervous system characterized by high morbidity, mortality, and healthcare costs. As conventional ischemic stroke models fail to predict therapeutic efficacy, in vitro neurovascular unit (NVU ...
Ze Liu +6 more
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Neurovascular Unit: a Focus on Pericytes
Molecular Neurobiology, 2012The blood-brain barrier (BBB) is a highly specialized system that controls the exchanges between the blood and the central nervous system (CNS). This barrier shields the CNS from toxic substances in the blood and provides nutrients to CNS, thus playing an essential role in the maintenance of homeostasis. The anatomical basis of the BBB is formed by the
Inês, Sá-Pereira +2 more
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An engineered neurovascular unit for modeling neuroinflammation
Biofabrication, 2021Abstract The neurovascular unit (NVU) comprises multiple types of brain cells, including brain endothelial cells, astrocytes, pericytes, neurons, microglia, and oligodendrocytes. Each cell type contributes to the maintenance of the molecular transport barrier and brain tissue homeostasis.
Suyeong Seo +8 more
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A Human Neurovascular Unit On-a-Chip
2021Protection of the central nervous system (CNS) and cerebral homeostasis depend upon the blood-brain barrier (BBB) functions and permeability. BBB restrictive permeability hinders drug delivery for the treatment of several neurodegenerative diseases and brain tumors.
Lee S. W. L. +5 more
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Ageing Research Reviews
Ischemic stroke(IS), a severe acute cerebrovascular disease, not only imposes a heavy economic burden on society but also presents numerous challenges in treatment.
Hailun Jiang +9 more
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Ischemic stroke(IS), a severe acute cerebrovascular disease, not only imposes a heavy economic burden on society but also presents numerous challenges in treatment.
Hailun Jiang +9 more
semanticscholar +1 more source
Drug Abuse and the Neurovascular Unit
2014Drug abuse continues to create a major international epidemic affecting society. A great majority of past drug abuse research has focused mostly on the mechanisms of addiction and the specific effects of substance use disorders on brain circuits and pathways that modulate reward, motivation, craving, and decision making. Few studies have focused on the
Richard D, Egleton, Thomas, Abbruscato
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Ferroptosis in the neurovascular unit after spinal cord injury.
Experimental NeurologyThe mechanisms of secondary injury following spinal cord injury are complicated. The role of ferroptosis, which is a newly discovered form of regulated cell death in the neurovascular unit(NVU), is increasingly important. Ferroptosis inhibitors have been
Yushan Huang, Jinzhu Bai
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2017
Abstract The neurovascular unit is a conceptual framework that emphasizes the importance of cell–cell signaling between neuronal, glial, and vascular cells for CNS function and dysfunction. During development, interactions between these multiple cell types provide the signals and substrates for CNS growth and maturation.
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Abstract The neurovascular unit is a conceptual framework that emphasizes the importance of cell–cell signaling between neuronal, glial, and vascular cells for CNS function and dysfunction. During development, interactions between these multiple cell types provide the signals and substrates for CNS growth and maturation.
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Introduction to the neurovascular unit
Journal of Cerebral Blood Flow & Metabolism, 2005For many years, a neurocentric view toward mechanisms of ischemic brain injury and repair has significantly contributed to our knowledge of the molecular pathways of excitotoxicity, oxidative stress and apoptosis. However, translation of these laboratory results into clinically effective stroke treatments remains a major challenge.
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