Results 71 to 80 of about 14,379,955 (286)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Solvent solutions: comparing extraction methods for edible oils and proteins in a changing regulatory landscape. Part 1: Physical-properties☆

Oilseeds and fats, crops and lipids
In the context of potential regulatory changes, this study compares the properties of various solvents for the extraction of edible oils. The solvents considered are hexane isomers, alcohols, ketones, ethyl acetate, dichloromethane and 2-methyloxolane ...
Carré Patrick, Berthold Sebastian, Piofczyk Thomas, Bothe Sarah, Hadjiali Sara   +4 more
doaj   +1 more source

Safety and Efficacy of GLP‐1 Receptor Agonists in Adults With Epilepsy, Obesity, and Type 2 Diabetes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Managing obesity in patients with epilepsy is complicated by the weight‐gaining properties of essential antiseizure medications (ASMs) such as valproate and pregabalin. We evaluated the safety and efficacy of initiating glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) in this population.
Hyoshin Son, Inyoung Hwang, Sang Won Lee, Yun Kim   +3 more
wiley   +1 more source

A generalized natural balance model and balance booster filter design for three-level neutral-point-clamped converters

, 2015
Three-level neutral point clamped (NPC) inverters exhibit a natural balancing property that can self-regulate the intermediate neutral point voltage to half the overall dc-link voltage.
Donald Grahame Holmes (18043990), Zaki Mohzani (19993662), Brendan McGrath (18031333)   +2 more
core  

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Effects of strike point location and collisional processes on energy and particle detachment in EAST with lower tungsten divertor

Nuclear Fusion
Divertor detachment is crucial for particle and power exhaust in future fusion reactors. The EAST lower tungsten divertor, with its ‘corner slot’ structure, exhibits remarkable geometric closure, and thus enhances neutral trapping.
Yilin Wang, Chaofeng Sang, Jianbin Liu, Niels Horsten, Xuele Zhao, Chen Zhang, Xin Lin, Yu Bian, Liang Wang, Tao Zhang, Dezhen Wang   +10 more
doaj   +1 more source

A Numerical–Experimental Approach for Multi‐Matrix Fiber‐Reinforced Plastics Characterization Using Finite Element Model Updating

Advanced Engineering Materials, EarlyView.
A numerical–experimental framework is developed for characterizing multi‐matrix fiber‐reinforced polymers (MM‐FRPs) combining epoxy and polyurethane matrices. Harmonic bending tests are integrated with finite element model updating (FEMU) to simultaneously identify elastic and viscoelastic material parameters.
Rodrigo M. Dartora, Tales V. Lisbôa, Axel Spickenheuer, Rogério J. Marczak, Jakson M. Vassoler   +4 more
wiley   +1 more source

A Simplified Laminar Flow Model for the Pultrusion of Glass Fiber/Polyethylene Terephthalate Commingled Yarns

Advanced Engineering Materials, EarlyView.
A simplified thermoplastic pultrusion model is developed to predict thermal fields in glass fiber/polyethylene terephthalate (GF/PET) composites with reduced computational cost. By combining effective material homogenization, validation against literature data, and Gaussian‐process‐based optimization, the study reveals how heating limits, pulling speed,
Elder Soares, Nadège Bouchonneau, Christian Jochum, Donald Radford   +3 more
wiley   +1 more source

Control of five-level flying capacitor based active-neutral-point-clamped converter for grid connected wind energy applications

, 2012
Integration of wind energy sources into the distribution grid affects the voltage profile that could be stabilized through the grid reinforcement or limiting the active power injection.
Sridhar Pulikanti (20124879), D Suntanto (20230305), Kashem Muttaqi (19588924)   +2 more
core   +1 more source

A study on the application of a three-level control technology for traction motors based on indirect stator quantities

机车电传动
In order to meet the requirements of high-power traction electric drive applications for high precision and fast response of motor output torque, this paper proposes a three-level drive control method for traction motors based on indirect stator ...
HU Liang, MEI Wenqing, LYU Yongcan, FU Xiangyu, XIAO Xinyu   +4 more
doaj