Results 121 to 130 of about 38,595 (171)

Neutral Endopeptidase Inhibitors and Atrial Natriuretic Peptide

The Journal of Clinical Pharmacology, 1991
A limited number of ectoenzymes appear to be involved in the inactivation of circulating‐regulatory peptides. Neutral endopeptidase 24.11, a metallopeptidase, is known to inactivate atrial natriuretic peptide (ANP), a substance with diuretic, natriuretic, and vasodilatory effects.
G, Achilihu, W H, Frishman, A, Landau
openaire   +2 more sources

Neutral endopeptidase modulates neurogenic inflammation

European Respiratory Journal, 1991
A noncholinergic, nonadrenergic nervous system has been described, involving the sensory nerves in the airways. Chemicals, dusts and other irritants stimulate these sensory nerves to release substance P and related neuropeptides. These neuropeptides have the remarkable ability to affect multiple cells in the airways and to provoke many responses ...
openaire   +2 more sources

Involvement of neutral endopeptidase in neoplastic progression

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2005
Neutral endopeptidase 24.11 (NEP) is a 90-110 kDa cell surface cell surface peptidase that is normally expressed by numerous tissues, including prostate, kidney, intestine, endometrium, adrenal glands and lung. This enzyme cleaves peptide bonds on the amino side of hydrophobic amino acids and inactivates a variety of physiologically active peptides ...
Makoto, Sumitomo, Ruoqian, Shen, David M, Nanus   +2 more
openaire   +2 more sources

Neutral endopeptidase modulates neurotensin-induced airway contraction

Journal of Applied Physiology, 1989
To determine the role of endogenous neutral endopeptidase (NEP) (also called enkephalinase, EC 3.4.24.11) in regulating neurotensin-induced airway contraction, we used phosphoramidon, a specific NEP inhibitor, in the guinea pig. In studies in vitro, neurotensin and the COOH-terminal fragment neurotensin-(8–13) contracted strips of bronchial smooth ...
T D, Djokic, D J, Dusser, D B, Borson, J A, Nadel   +3 more
openaire   +2 more sources

Neutral endopeptidase inhibition in diabetic wound repair

Wound Repair and Regeneration, 2002
In response to cutaneous injury, sensory nerves release substance P, a proinflammatory neuropeptide. Substance P stimulates mitogenesis and migration of keratinocytes, fibroblasts, and endothelial cells. Neutral endopeptidase (NEP), a cell surface metallopeptidase, degrades substance P.
Michelle L, Spenny, Pornprom, Muangman, Stephen R, Sullivan, Nigel W, Bunnett, John C, Ansel, John E, Olerud, Nicole S, Gibran   +6 more
openaire   +2 more sources

Prolonged neutral endopeptidase inhibition in heart failure

European Journal of Pharmacology, 1991
We studied the hormonal, renal and hemodynamic effects of prolonged treatment with SCH 39370, a new neutral endopeptidase (NEP) inhibitor, in experimental congestive heart failure (CHF). Coronary-ligated CHF rats and sham-operated controls received vehicle or SCH 39370 30 mg/kg s.c. twice daily for six days.
K, Helin, I, Tikkanen, T, Tikkanen, O, Saijonmaa, E J, Sybertz, S, Vemulapalli, H, Sariola, F, Fyhrquist   +7 more
openaire   +2 more sources

Roles of neutral endopeptidase in airways

American Journal of Physiology-Lung Cellular and Molecular Physiology, 1991
In recent years, studies of the regulation of the airways have focused to an increasing degree on the roles of neuropeptides. Several peptides have been shown to be present in airways and mediate such diverse responses as ion transport, mucus secretion, bronchospasm or relaxation, edema, cough, changes in vascular permeability, and neutrophil ...
openaire   +2 more sources

Neutral endopeptidase inhibitors and the pulmonary circulation

General Pharmacology: The Vascular System, 1996
1. Neutral endopeptidase (NEP) EC 3.4.24.11 is a zinc-metallopeptidase which is partly responsible for the degradation of atrial natriuretic peptide (ANP) in vivo. 2. ANP inhibits vascular smooth muscle cell proliferation, and elicits vasorelaxation of the systemic and, more potently, the pulmonary vasculature.
J S, Thompson, A H, Morice
openaire   +2 more sources

Modulation of Neurogenic Inflammation by Neutral Endopeptidase

American Review of Respiratory Disease, 1991
The enzyme neutral endopeptidase (NEP) is bound to the membranes of selected cells in the airways that have receptors for tachykinins. The location of the enzyme, along with its selectivity of substrates (tachykinins are a preferred substrate), allows the enzyme to cleave tachykinins that come close to the cell-surface receptors.
J A, Nadel, D B, Borson
openaire   +2 more sources

Inhibition of Kidney Neutral Endopeptidase After Administration of the Neutral Endopeptidase Inhibitor Candoxatril: Quantitation by Autoradiography

Journal of Cardiovascular Pharmacology, 1998
Inhibition of neutral endopeptidase (NEP) in the kidney was studied ex vivo after oral administration of candoxatril (UK79300), an NEP inhibitor, to rats to study the time course and dose response by quantitative in vitro autoradiography by using the NEP inhibitor 125I-SCH47896 as a radioligand. In control rats, high NEP binding was demonstrated in the
K, Yoshida, M, Kanazawa, D J, Casley, A, Katopothis, C I, Johnston   +4 more
openaire   +2 more sources