Results 131 to 140 of about 38,595 (171)

Microvillar membrane neutral endopeptidases.

Acta biologica et medica Germanica, 1982
Recent developments on neutral endopeptidase (NEP, EC 3.4.24.11) are described. These include (1) the development of a novel colorimetric assay with a chromogenic substrate (Glutaryl-Gly-Gly-Phe-2-naphthylamide) coupled with aminopeptidase M (EC 3.4.11.2).
A J, Kenny, I S, Fulcher, K, Ridgwell, J, Ingram   +3 more
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Neutral endopeptidase from nuchal ligament of fetal calves

Journal of Cellular Biochemistry, 1990
AbstractThe nuchal ligament of unborn calves contains a neutral endopeptidase that is biochemically and immunologically similar to the neutral endopeptidase (NEP), or enkephalinase, from human kidney. Enzymatic activity was inhibited more than 90% by phosphora midon (1 μM). The specific activity in membrane fractions, as determined by hydrolysis of the
A R, Johnson, L D, Gray, E, Youngblood, J, Sullivan   +3 more
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POTENTIATION OF NATRIURETIC PEPTIDES BY NEUTRAL ENDOPEPTIDASE INHIBITORS

Clinical and Experimental Pharmacology and Physiology, 1995
SUMMARY1. Inhibitors of neutral endopeptidase (NEP) EC 3.4.24.11 were developed to regulate endogenous levels of the natriuretic and vasodilatory hormone atrial natriuretic peptide (ANP). The selective NEP inhibitor SQ 28603 enhanced the increases in plasma ANP and urinary excretion of ANP, cyclic GMP and sodium stimulated by infusion of human ANP in ...
A A, Seymour, B E, Abboa-Offei, P L, Smith, P D, Mathers, M M, Asaad, W L, Rogers   +5 more
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Inhibition of neutral endopeptidase (NEP) facilitates neurogenic inflammation

Experimental Neurology, 2005
Neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE) are involved in neuropeptide degradation and may modulate neurogenic inflammation. We therefore explored the effect of specific blockers of NEP and ACE on the intensity of neurogenic inflammation. We investigated eight subjects on three occasions.
H H, Krämer, K, Schmidt, S, Leis, M, Schmelz, C, Sommer, F, Birklein   +5 more
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Cytokines Increase Neutral Endopeptidase Activity in Lung Fibroblasts

American Journal of Respiratory Cell and Molecular Biology, 1993
Fibroblasts of the pulmonary interstitium are intimately involved in the response of the lung to inflammation as well as in repair of injured tissues. The response of fibroblasts within an inflammatory site appears to be directed, in part, by peptide mediators.
A, Kondepudi, A, Johnson
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Positional Effects in the Neprilysin (Neutral Endopeptidase) Reaction

Archives of Biochemistry and Biophysics, 1994
Neprilysin is a peptidase which has a specificity directed toward cleavage on the amino side of hydrophobic residues. In addition an active site arginine on the enzyme can interact with the C-terminal carboxylate of a substrate. The importance of the position of the hydrophobic residue relative to the C-terminus of the substrate has been investigated ...
T, Quay, C, Slaughter, T P, Davis, B J, Merrill, L B, Hersh   +4 more
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Candoxatril, a neutral endopeptidase inhibitor

Journal of Hypertension, 1992
To examine the efficacy and tolerability of the neutral endopeptidase inhibitor, candoxatril (UK 79,300) as monotherapy in essential hypertension.Double-blind, placebo-controlled, parallel-group study of 28 days' duration.Three hospital outpatient departments participating in the Glasgow Blood Pressure Clinic (Glasgow, UK).Forty patients with essential
E G, Bevan, J M, Connell, J, Doyle, H A, Carmichael, D L, Davies, A R, Lorimer, G T, McInnes   +6 more
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Subcellular Distribution of Prolyl Endopeptidase and Cation‐Sensitive Neutral Endopeptidase in Rabbit Brain

Journal of Neurochemistry, 1982
Abstract: The subcellular distribution of prolyl endopeptidase, and of cationsensitive neutral endopeptidase, two enzymes actively metabolizing many neuropeptides, was determined in homogenates of rabbit brain. The subcellular distribution of both enzymes was more similar to lactate dehydrogenase, a cytoplasmic enzyme marker, than to choline ...
K, Dresdner, L A, Barker, M, Orlowski, S, Wilk   +3 more
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Reaction of Opioid Peptides with Neutral Endopeptidase (‘Enkephalinase”)

Journal of Neurochemistry, 1984
Abstract: The kinetics of the reactions of nine opioid peptides with the neutral endopeptidase (“enkephalinase”) activities of human kidney, rat kidney, and rat brain have been determined. These opioid peptides can be divided into two classes, those that are good inhibitors of Leu5‐enkephalin hydrolysis (K1 < 75 μM) and good substrates for the ...
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Anti-Angiogenic Action of Neutral Endopeptidase

2005
Abstract : Angiogenesis, or the formation of new blood vessels from existing vasculature is an important event in tumor progression. It results from a complex, multistep biochemical cascade that is initiated by the activation of endothelial cells in response to angiogenic factors.
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