Results 41 to 50 of about 1,483,833 (292)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The edge of neutral evolution in social dilemmas [PDF]
, 2009 The functioning of animal as well as human societies fundamentally relies on cooperation. Yet, defection is often favorable for the selfish individual, and social dilemmas arise.
Reichenbach, Tobias +2 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Bathers at Dr. Smith's Neutral Waters Health Resort, Egg Harbor City, NJ..
, 1890 Photographic postcard of bathers at Dr. Smith's Neutral Waters Health Resort and Sanitorium in Egg Harbor City, NJ.
core +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Asmptotically Plane Wave Spacetimes [PDF]
, 2009 In this thesis we study aspects of plane wave spacetimes in the hope of shedding light of the nature of holography for plane waves. In particular, we would like to understand better the space of asymptotically plane wave solutions.
LE-WITT, JULIAN,ALEXANDER +1 more
core
Journal of Marine Science and EngineeringLarge-diameter rock-socketed monopiles supporting offshore wind turbines in soft clay strata face significant geotechnical risks from negative skin friction (NFS) induced by construction surcharges.
Yuanyuan Ren, Zhiwei Chen, Wenbo Zhu
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Global flow behaviors of multiple shafts in shallow-buried urban road tunnels subjected to fire load
Underground SpaceShallow-buried urban road tunnels with shafts (URTS) have reduced traffic congestion in large cities. During fire scenarios, the backflows occur at those shafts far away from the fire source inhibiting smoke exhaust, but its rules have been unknown.
Daolong Xiong +7 more
doaj +1 more source