Results 71 to 80 of about 1,483,833 (292)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

open access: yesMolecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen   +19 more
wiley   +1 more source

Homoclinic snaking in a neutral delay model of a transmission line oscillator [PDF]

open access: yes, 2006
In a transmission line oscillator (TLO) a linear wave travels along a piece of cable, the transmission line, and interacts with terminating electrical components.
Wilson, RE, Barton, DAW, Krauskopf, B
core  

VENM: An Algorithm to Accurately Calculate Neutral Slopes and Gradients

open access: yesJournal of Advances in Modeling Earth Systems, 2019
Mesoscale eddies stir along the neutral plane, and the resulting neutral diffusion is a fundamental aspect of subgrid‐scale tracer transport in ocean models.
Sjoerd Groeskamp   +4 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Regulation of neutral ceramidase in glomerular messangial cells [PDF]

open access: yes, 2009
During the past several years, ceramide has emerged as an important second messenger triggering cell responses including proliferation, differentiation, growth arrest and apoptosis.
Franzen, Rochus
core  

Study on capacity of single pile subjected to surrounding soil’s settlement

open access: yesTạp chí Khoa học Đại học Mở Thành phố Hồ Chí Minh - Kỹ thuật và Công nghệ, 2012
Piles driven to clay are often subjected to surrounding soil’s settlement due to consolidation and second consolidation of soft soil. Since surrounding soil’s downward movements are larger than piles’s, negative skin friction develop develops on the ...
Võ Phán, Nguyễn Trung Kiên
doaj  

Numerical analysis of negative skin friction on piles in soft clay

open access: yesHBRC Journal, 2013
Negative skin friction is considered one of the problems in the design of piled foundations in soft soil. The negative skin friction induces an additional compressive force on the pile called the dragload as well as, an additional pile movement called ...
Yasser M. El-Mossallamy   +3 more
doaj   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

open access: yesFEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura   +19 more
wiley   +1 more source

FEM simulation of infeed rotary swaging with structured tools

open access: yesMATEC Web of Conferences, 2015
Rotary swaging is an incremental cold forming process for rods and tubes. Infeed rotary swaging with structure in the reduction zone of the tools is investigated using a two dimensional finite element simulation.
Herrmann Marius   +2 more
doaj   +1 more source

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