Results 21 to 30 of about 200,521 (267)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The social cost of carbon in regions and industries from ESG perspective - a case study of eight economic regions in China

Carbon Balance and Management
As a core metric for climate policy, the scientific estimation of carbon social costs is crucial for formulating mitigation strategies. However, traditional integrated assessment models predominantly focus on the global aggregate, failing to adequately ...
Zihao Tian, Lixin Tian, Yixiang Zhao
doaj   +1 more source

A water stable Cu-MOF/GO composite as a persulfate activator for efficient degradation of dye wastewater

Journal of Saudi Chemical Society
Water pollution caused by textile dyes is considered a major and growing issue. To address this challenge, in this research, water-stable Cu-MOFs/GO composite catalysts were produced using the hydrothermal synthesis method as an efficient persulfate (PDS)
Chuanqi Zhao, Yuxuan Chen, Sinuo Gong, Wen Tan, Honghui Pan, Xixiang Liu, Qin Shi   +6 more
doaj   +1 more source

HETEROSIS OR NEUTRALITY? [PDF]

Genetics, 1977
ABSTRACT Various statistics have been proposed on an ad hoc basis to test whether alleles at a locus are selectively neutral. By considering population models in which selection operates, this paper shows that the population homozygosity is a powerful test statistic for testing departures from neutrality, in the direction of heterozygote
openaire   +2 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Anti-aggregation self-assembled monolayers enable high-performance and scalable perovskite solar cells

Nature Communications
Stable self-assembled monolayers (SAMs), such as (2-(9H-carbazol-9-yl)) ethylphosphonic acid (2PACz), are crucial for reducing interfacial energy loss in high-performance perovskite solar cells (PSCs).
Kaihuai Du, Chunna Huang, Aili Wang, Haoran Zhang, Lvzhou Li, Xu Dong, Luozheng Zhang, Mohammad Khaja Nazeeruddin, Guixiang Li, Jianning Ding   +9 more
doaj   +1 more source

Optimization of CO₂ Flooding Strategies for an Undeveloped Chang 8 Tight Oil Reservoir in the Ordos Basin, China

Energies
The Chang 8 tight oil reservoir in the Xifeng area of the Ordos Basin is characterized by poor reservoir properties, making conventional water flooding ineffective for efficient reservoir development.
Jiwei Wang, Peihao Xu, Long Liu, Yongjian Feng, Qiang Liu, Qinglong Zhu, Luming Shi, Wei Wang   +7 more
doaj   +1 more source

Carbon Quantum Dots Bridged TiO₂/CdIn₂S₄ toward Photocatalytic Upgrading of Polycyclic Aromatic Hydrocarbons to Benzaldehyde

Molecules, 2022
Conversion of hazardous compounds to value-added chemicals using clean energy possesses massive industrial interest. This applies especially to the hazardous compounds that are frequently released in daily life.
Jiangwei Zhang, Fei Yu, Xi Ke, He Yu, Peiyuan Guo, Lei Du, Menglong Zhang, Dongxiang Luo   +7 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source