Results 31 to 40 of about 200,521 (267)

CO2 leakage alters bacterial community structure and metabolic function of soybean rhizosphere in the Ordos Basin

Scientific Reports
CO2 capture and storage (CCS) is a pivotal technology for mitigating global climate change, but CO2 leakage from geological storage sites risks disrupting soil rhizosphere bacterial communities critical to soil functionality.
Lu Xue, Junjie Ma, Haofan Wang, Lin Li, Jinfeng Ma   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Current Status and Prospects of Resource Recycling Technology for Fiber-Reinforced Polymers in the New Energy Industry

能源环境保护
Fiber-reinforced polymers (FRPs), composed of reinforcing fibers and resin matrices, exhibit outstanding characteristics such as low density, high strength, corrosion resistance, and superior mechanical performance.
Long JIAO, Ye HUA, Jiaxin XU, Guohao YANG, Jiajie ZHANG, Xinhui CHEN, Rouhan JIN, Yanjun HU   +7 more
doaj   +1 more source

CNTs/CNPs/PVA–Borax Conductive Self-Healing Hydrogel for Wearable Sensors

Gels
The development of multifunctional conductive hydrogels with rapid self-healing capabilities and powerful sensing functions is crucial for advancing wearable electronics.
Chengcheng Peng, Ziyan Shu, Xinjiang Zhang, Cailiu Yin   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Accelerated Development of Vapor Deposition Technology for Efficient Perovskite Solar Cells via Accurate and Practical Machine Learning Tools

Advanced Science
The development of vapor deposition technology will accelerate the process of perovskite solar cells (PSCs) moving from laboratory scale to industrialization. However, the multi‐dimensional and complex parameter space will inevitably increase the cost of
Long Luo, Ziyang Gao, Muyi Fang, Yu Shen, Shuaizhang Chen, Yuchen Bu, Junjie Gu, Cheng Hu, Jianning Ding   +8 more
doaj   +1 more source

Deep Learning-Enabled Flexible PVA/CNPs Hydrogel Film Sensor for Abdominal Respiration Monitoring

Gels
In this study, a flexible hydrogel film sensor based on the intermixing of poly(vinyl alcohol) (PVA) and biomass-derived carbon nanoparticles (CNPs) was prepared and microstructures were constructed by replicating sandpaper templates on its surface.
Chengcheng Peng, Xinjiang Zhang, Ziyan Shu, Cailiu Yin, Baorong Liu   +4 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Stimulus-Responsive Afterglow Carbon Dots from Internal Mechanism to Potential Application

Nanomaterials
Stimulus-responsive afterglow materials refer to a class of substances whose afterglow characteristics alter under external stimuli, showing considerable potential for advanced applications in anti-counterfeiting, optoelectronic displays, chemical ...
Chongye Xia, Xingyu Gu, Xingwang Zhu, Yunfei Sun, Qijun Li, Jing Tan   +5 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source