Results 51 to 60 of about 404,578 (298)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Current Status and Prospects of Resource Recycling Technology for Fiber-Reinforced Polymers in the New Energy Industry

能源环境保护
Fiber-reinforced polymers (FRPs), composed of reinforcing fibers and resin matrices, exhibit outstanding characteristics such as low density, high strength, corrosion resistance, and superior mechanical performance.
Long JIAO, Ye HUA, Jiaxin XU, Guohao YANG, Jiajie ZHANG, Xinhui CHEN, Rouhan JIN, Yanjun HU   +7 more
doaj   +1 more source

Stimulus-Responsive Afterglow Carbon Dots from Internal Mechanism to Potential Application

Nanomaterials
Stimulus-responsive afterglow materials refer to a class of substances whose afterglow characteristics alter under external stimuli, showing considerable potential for advanced applications in anti-counterfeiting, optoelectronic displays, chemical ...
Chongye Xia, Xingyu Gu, Xingwang Zhu, Yunfei Sun, Qijun Li, Jing Tan   +5 more
doaj   +1 more source

Evaluation of two eco-friendly neutralizers for a spectrum of tissue fixatives for biomedical applications. [PDF]

, 2018
Formaldehyde is a widely used aldehyde in biomedical applications, including tissue fixation. It is this same fixative property that can result in toxicity if aldehydes are improperly discarded.
Carmichael, Stanley Thomas, Prakash, Roshini   +1 more
core  

The production and development of H7 Influenza virus pseudotypes for the study of humoral responses against avian viruses [PDF]

, 2013
In recent years, high pathogenicity avian influenza (HPAI) virus, H5N1, low pathogenicity avian influenza (LPAI) virus, H9N2, and both HPAI and LPAI H7 viruses have proved devastating for the affected economies reliant on poultry industry, and have posed
Böttcher-Frieberthäuser, Eva, Cattoli, Giovanni, Ferrara, Francesca, Molesti, Eleonora, Temperton, Nigel, Terregino, Calogero   +5 more
core   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Coincident brane nucleation and the neutralization of \Lambda [PDF]

, 2003
Nucleation of branes by a four-form field has recently been considered in string motivated scenarios for the neutralization of the cosmological constant.
A. Vilenkin, A.D. Linde, A.D. Linde, Ariel Megevand, D. Muller, D.A. Samuel, G. Dvali, H. Martel, H. Nariai, J. Garriga, J. Garriga, J. Garriga, J. Garriga, J. Garriga, J. Garriga, J. Guven, J.D. Brown, J.D. Brown, J.J. Halliwell, J.L. Feng, J.M. Maldacena, Jaume Garriga, N. Kaloper, P. Candelas, P. Ginsparg, R. Basu, R. Bousso, S. Coleman, S. Coleman, S. Kachru, S. Kachru, S.B. Giddings, T. Vachaspati, V.A. Berezin, W. Israel, W. Israel, X. Montes, Y.P. Goncharov   +37 more
core   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Many Body Theory of Charge Transfer in Hyperthermal Atomic Scattering

, 1992
We use the Newns-Anderson Hamiltonian to describe many-body electronic processes that occur when hyperthermal alkali atoms scatter off metallic surfaces. Following Brako and Newns, we expand the electronic many-body wavefunction in the number of particle-
A. G. Borisov, A. J. Algra, B. H. Cooper, B. Hird, B. Rasser, C. A. DiRubio, C. A. DiRubio, C. C. Hsu, C. Kane, C. Langreth, C. Langreth, C. M. Varma, C. Richardson, D. L. Adler, D. M. Goodstein, D. R. Andersson, D. V. Averin, E. C. Goldberg, E. R. Behringer, E. R. Behringer, G. A. Kimmel, G. A. Kimmel, H. Brenten, H. Brenten, H. Kasai, H. Nakanishi, H. Schall, H. Schall, J. B. Marston, J. Hermann, J. J. C. Geerlings, J. J. C. Geerlings, J. J. C. Geerlings, J. Los, K. L. Sebastian, K. W. Sulston, K. W. Sulston, M. J. Ashwin, M. L. Yu, N. Andrei, N. Andrei, N. Lorente, O. Gunnarsson, P. B. Wiegmann, P. Nordlander, P. Nordlander, P. Nordlander, P. Nordlander, P. O. Gartland, P. O. Gartland, R. Brako, R. Brako, R. Brako, R. L. McEachern, R. Zimny, R. Zimny, T. Dorsey, Tony Fónden, X. Nakanishi, X. Nakanishi, Y. Bu   +60 more
core   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source