Results 31 to 40 of about 5,636,000 (300)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Assessment of the ability of SARS-CoV-2 strains of genetic variants B.1.1 and JN.1 to evade neutralizing antibodies from 2020 and 2023 convalescent patients

Инфекция и иммунитет
Introduction. The SARS-CoV-2 virus is a highly variable pathogen accounted for by random mutations leading to the emergence of new genetic variants. Natural selection of SARS-CoV-2 variants is, among other things, the result of population level immunity ...
Stepan A. Pyankov, A. V. Zaykovskaya, A. V. Rybel, S. A. Bodnev, O. V. Pyankov   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

The immune response after vaccination in recipients against different subtypes of tick-borne encephalitis virus (Flaviviridae: Orthoflavivirus)

Вопросы вирусологии
Introduction. There are three antigenic subtypes of tick-borne encephalitis virus (TBEV): the European, Far Eastern and Siberian subtypes. The article discusses the topic of cross-protective neutralizing antibodies against different subtypes of TBEV ...
Ekaterina A. Orlova, Alla L. Ivanova, Vladimir A. Mishchenko, Ivan P. Bykov, Ivan V. Vyalykh, Natalia L. Fadeeva, Veronica V. Patlusova, Mikhail F. Vorovitch, Nadezhda M. Kolyasnikova   +8 more
doaj   +1 more source

Dickkopf 1 impairs the tumor response to PD-1 blockade by inactivating CD8+ T cells in deficient mismatch repair colorectal cancer

Journal for ImmunoTherapy of Cancer, 2021
Background Dickkopf 1 (DKK1) is associated with tumor progression. However, whether DKK1 influences the tumor response to programmed cell death protein 1 (PD-1) blockade in colorectal cancers (CRCs) with deficient mismatch repair (dMMR) or microsatellite
Yuan Li, Jian Zheng, Zhizhong Pan, Penghui Zhou, Guochen Liu, Wu Jiang, Pei-Rong Ding, Zexian Liu, Qiaoqi Sui, Dingxin Liu, Jinghua Tang, Lingheng Kong, Kai Han, Leen Liao, Qingjian Ou, Binyi Xiao, Yihong Ling, Jiewei Chen, Zhixiang Zuo   +18 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Evaluation of a Reverse Transcription-Quantitative Polymerase Chain Reaction (RT-qPCR)-Based Microneutralization Assay for Assessing Clinical Human Cytomegalovirus-Neutralizing Antibody Activity

Microorganisms
Development of a vaccine for human cytomegalovirus (hCMV) is critical because of the severe consequences of infection in congenitally infected newborns and immunocompromised patients.
Jiaao Yu, Maria E. Hasing, Jutta K. Preiksaitis, Xiaoli Pang   +3 more
doaj   +1 more source

Diisopropylammonium 4-aminobenzenesulfonate

IUCrData, 2016
The title molecular salt, C6H16N+·C6H6NO3S−, was synthesized from a neutralization reaction between sulfanilic acid and diisopropylamine. The crystal structure consists of diisopropylammonium cations and 4-aminobenzenesulfonate (sulfanilate) anions ...
Bougar Sarr, Cheikh Abdoul Khadir Diop, Libasse Diop, Florent Blanchard, Francois Michaud   +4 more
doaj   +1 more source

TOXIN-ANTITOXIN REACTION WITHOUT NEUTRALIZATION [PDF]

Journal of Experimental Medicine, 1932
1. Collodion particles adsorb diphtheria or tetanus or botulinus toxins. These toxins are retained on the particles when washed but are at least in part released in the animal. 2. The adsorbed toxins are neutralized by adsorption of the corresponding antitoxins but are unaffected by other serums. 3.
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source