Results 41 to 50 of about 5,636,000 (300)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Phase transformations kinetics in barium titanate synthesis by mechanochemical processing [PDF]
Hemijska IndustrijaThis article presents the research results on a dry mechanochemical synthesis of barium titanate at a low temperature in which the reaction model and kinetics were determined during the activation of a powder mixture of titanium dioxide and barium oxide.
Đorđević Nataša G. +4 more
doaj +1 more source
Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region
FEBS Open Bio, EarlyView.Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson +2 more
wiley +1 more source
Process optimization using response surface design for diacylglycerol synthesis from palm fatty acid distillate by enzymatic esterification [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2013 Diacylglycerols (DAG) were synthesized by lipase-catalyzed esterification of glycerol with palm fatty acid distillate(PFAD). Lipase from Rhizomucor miehei was used and the reaction was carried out at 45°C.
Songsri Santisawadi +3 more
doaj
Indonesian Journal of Chemistry, 2018 The overall objectives of the research were (1) to study the capability of sodium hydrosulfide (NaHS) and sulfidic natural water (SNW) of Sebau in recovery of Cu2+, (2) to investigate the potency of integrating treatments of neutralization with ...
Surya Hadi +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source
Jurnal Teknik Kimia dan Lingkungan, 2017 Surfactant is a surface active agent which is widely applied in chemical industry related to its ability to stabilize the emulsion between the oil phase and the water phase.
Abdul Chalim +4 more
doaj +1 more source
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
A PRELIMINARY STUDY ON VACCINATION OF CALVES WITH RINDERPEST AND BCG VACCINES [PDF]
Assiut Veterinary Medical Journal, 1987 A preliminary study on calves dually vaccinated with Tissue Culture Rinderpest (TCRPV) and BCG vaccines revealed that the development of serum-Rinderpest neutralizing antibodies was enhanced. The development of cytopathic effect (CPE) of Rinderpest virus
O.A. OSMAN +3 more
doaj +1 more source