Results 51 to 60 of about 75,680 (266)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

SARS-CoV-2 antibody progression and neutralizing potential in mild symptomatic COVID-19 patients – a comparative long term post-infection study

Frontiers in Immunology, 2022
BackgroundSince December 2019, SARS-CoV-2 has been keeping the world in suspense. Rapid tests, molecular diagnosis of acute infections, and vaccination campaigns with vaccines are building blocks of strategic pandemic control worldwide.
Jessica Brehm, Alexander Spaeth, Lars Dreßler, Thomas Masetto, Thomas Masetto, Rainer Dannenberg, Christoph Peter, Matthias Grimmler, Matthias Grimmler   +8 more
doaj   +1 more source

Neutralization tests with varicella-zoster virus [PDF]

Journal of Hygiene, 1969
SUMMARYA technique for neutralization tests using varicella-zoster virus propagated in primary human thyroid cells is described. The level of neutralizing antibody following chickenpox does not usually exceed a titre of 1/40 and in adults many years after infection it may be very low.
A E, Caunt, D G, Shaw
openaire   +2 more sources

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

The development and application of an indirect Elisa test for the detection of antibodies to bovine respiratory syncytial virus in blood serum

Veterinární Medicína, 2001
We developed an indirect enzyme-linked immunosorbent assay (ELISA) for detection of serum antibodies to bovine respiratory syncytial virus. For evaluation of the newly developed ELISA, field sera collected from 549 head of cattle in the Czech Republic ...
K. Kovařčík
doaj   +1 more source

Tests of the Equivalence Principle with neutral kaons [PDF]

Physics Letters B, 1999
We test the Principle of Equivalence for particles and antiparticles, using CPLEAR data on tagged K0 and K0bar decays into pi^+ pi^-. For the first time, we search for possible annual, monthly and diurnal modulations of the observables |eta_{+-}| and phi_{+-}, that could be correlated with variations in astrophysical potentials.
Apostolakis, A., Aslanides, E., Backenstoss, G., Bargassa, P., Behnke, O., Benelli, A., Bertin, V., Blanc, F., Bloch, P., Carlson, P., Carroll, M., Cawley, E., Chardin, G., Chertok, M.B., Danielsson, M., Dejardin, M., Derre, J., Ealet, A., Eleftheriadis, C., Faravel, L., Fetscher, W., Fidecaro, M., Filipcic, A., Francis, D., Fry, J., Gabathuler, E., Gamet, R., Gerber, H.J., Go, A., Haselden, A., Hayman, P.J., Henry-Couannier, F., Hollander, R.W., Jon-And, K., Kettle, P.R., Kokkas, P., Kreuger, R., Le Gac, R., Leimgruber, F., Mandic, I., Manthos, N., Marel, G., Mikuz, M., Miller, J., Montanet, F., Müller, A., Nakada, T., Pagels, B., Papadopoulos, I., Pavlopoulos, P., Polivka, G., Rickenbach, R., Roberts, B.L., Ruf, T., Sakeliou, L., Schafer, M., Schaller, L.A., Schietinger, T., Schopper, A., Tauscher, L., Thibault, C., Touchard, F., Touramanis, C., van Eijk, C.W.E., Vlachos, S., Weber, P., Wigger, O., Wolter, M., Zavrtanik, D., Zimmerman, D., Ellis, J., Mavromatos, N.E., Nanopoulos, D.V.   +72 more
openaire   +4 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source