Results 11 to 20 of about 1,883,437 (383)

Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies

Nature, 2021
The SARS-CoV-2 B.1.1.529 (Omicron) variant contains 15 mutations of the receptor-binding domain (RBD). How Omicron evades RBD-targeted neutralizing antibodies requires immediate investigation.
Yunlong Cao, Jing Wang, F. Jian, T. Xiao, Weiliang Song, A. Yisimayi, Weijing Huang, Qian-qian Li, Peng Wang, R. An, Jing Wang, Yao Wang, Xiaowei Niu, Sijie Yang, Huitong Liang, Haiyan Sun, Taojing Li, Yuanling Yu, Qianqian Cui, Shuo Liu, Xiaodong Yang, Shuo Du, Zhiying Zhang, Xiaohua Hao, Fei Shao, R. Jin, Xiangxi Wang, Junyu Xiao, Youchun Wang, X. Xie   +29 more
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Antiviral neutralizing antibodies: from in vitro to in vivo activity

Nature reviews. Immunology, 2023
Neutralizing antibodies (nAbs) are being increasingly used as passive antiviral reagents in prophylactic and therapeutic modalities and to guide viral vaccine design.
D. Burton
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Neutralizing antibodies against the SARS-CoV-2 Delta and Omicron variants following heterologous CoronaVac plus BNT162b2 booster vaccination

Nature Medicine, 2022
The recent emergence of the SARS-CoV-2 Omicron variant is raising concerns because of its increased transmissibility and its numerous spike mutations, which have the potential to evade neutralizing antibodies elicited by COVID-19 vaccines.
E. Pérez-Then, C. Lucas, V. Monteiro, M. Mirić, V. Brache, L. Cochón, C. Vogels, A. Malik, Elena De la Cruz, A. Jorge, M. De los Santos, P. León, M. Breban, K. Billig, I. Yildirim, C. Pearson, R. Downing, E. Gagnon, A. Muyombwe, J. Razeq, M. Campbell, A. Ko, S. Omer, N. Grubaugh, S. Vermund, A. Iwasaki   +25 more
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Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model

Science, 2020
Protective neutralizing antibodies Antibodies produced by survivors of coronavirus disease 2019 (COVID-19) may be leveraged to develop therapies. A first step is identifying neutralizing antibodies, which confer strong protection against severe acute ...
T. Rogers, Fangzhu Zhao, Deli Huang, N. Beutler, Alison Burns, Wan-ting He, Oliver Limbo, C. Smith, G. Song, J. Woehl, Linlin Yang, R. Abbott, Sean Callaghan, Elijah Garcia, Jonathan Hurtado, M. Parren, Linghang Peng, S. Ramirez, James Ricketts, M. Ricciardi, Stephen A. Rawlings, N. Wu, M. Yuan, Davey M. Smith, D. Nemazee, J. Teijaro, J. Voss, I. Wilson, R. Andrabi, Bryan S. Briney, E. Landais, D. Sok, J. Jardine, D. Burton   +33 more
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Broadly neutralizing antibodies to SARS-CoV-2 and other human coronaviruses

Nature reviews. Immunology, 2022
The ancestral strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved into a number of variants of concern. In this Review, Wang and colleagues discuss progress in the development and characterization of broadly neutralizing ...
Yanjia Chen, Xiaoyu Zhao, Hao Zhou, Huanzhang Zhu, Shibo Jiang, Pengfei Wang   +5 more
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Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies

Nature reviews. Immunology, 2022
After nearly four decades of research, a safe and effective HIV-1 vaccine remains elusive. There are many reasons why the development of a potent and durable HIV-1 vaccine is challenging, including the extraordinary genetic diversity of HIV-1 and its ...
B. Haynes, K. Wiehe, P. Borrow, K. Saunders, Bette Korber, K. Wagh, A. McMichael, G. Kelsoe, B. Hahn, F. Alt, G. Shaw   +10 more
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HIV-1 Env Does Not Enable the Development of Protective Broadly Neutralizing Antibodies in an Experimental Autoimmune Encephalomyelitis Mouse Model

Frontiers in Immunology, 2021
Recent studies showed that immunological tolerance may restrict the development of Env-specific autoreactive broadly neutralizing antibodies. This evidence is consistent with the finding that Env immunization of a systemic lupus erythematosus (SLE ...
Gabriel Siracusano, Annamaria Finardi, Claudia Pastori, Vittorio Martinelli, Roberto Furlan, Lucia Lopalco   +5 more
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Low levels of monkeypox virus-neutralizing antibodies after MVA-BN vaccination in healthy individuals

Nature Medicine, 2022
In July 2022, the ongoing monkeypox (MPX) outbreak was declared a public health emergency of international concern. Modified vaccinia Ankara—Bavarian Nordic (MVA-BN, also known as Imvamune, JYNNEOS or Imvanex) is a third-generation smallpox vaccine that ...
Luca M. Zaeck, M. Lamers, B. Verstrepen, T. Bestebroer, M. V. van Royen, H. Götz, M. Shamier, L. V. van Leeuwen, K. Schmitz, Kimberley Alblas, Suzanne van Efferen, S. Bogers, S. Scherbeijn, G. Rimmelzwaan, E. V. van Gorp, M. Koopmans, B. Haagmans, C. Geurtsvankessel, R. D. de Vries   +18 more
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Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

Science, 2020
Sites of vulnerability in SARS-CoV-2 Antibodies that neutralize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could be an important tool in treating coronavirus disease 2019 (COVID-19). Brouwer et al.
P. Brouwer, Tom G. Caniels, K. van der Straten, Jonne L. Snitselaar, Y. Aldon, S. Bangaru, J. Torres, Nisreen M. A. Okba, M. Claireaux, G. Kerster, A. Bentlage, M. M. van Haaren, Denise Guerra, J. Burger, Edith E. Schermer, K. Verheul, N. van der Velde, Alex van der Kooi, J. van Schooten, M. V. van Breemen, Tom P. L. Bijl, Kwinten Sliepen, A. Aartse, R. Derking, I. Bontjer, N. Kootstra, W. Wiersinga, G. Vidarsson, B. Haagmans, A. Ward, G. D. de Bree, R. Sanders, M. V. van Gils   +32 more
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Broadly neutralizing antibodies target the coronavirus fusion peptide

bioRxiv, 2022
The potential for future coronavirus outbreaks highlights the need to develop strategies and tools to broadly target this group of pathogens. Here, using an epitope-agnostic approach, we identified six monoclonal antibodies that bound to spike proteins ...
Cherrelle Dacon, C. Tucker, Linghang Peng, C. D. Lee, Ting-Hui Lin, M. Yuan, Yu Cong, Lingshu Wang, Lauren Purser, Jazmean K. Williams, C. Pyo, Ivan Košík, Zhe Hu, Ming Zhao, Divya Mohan, Andrew J. R. Cooper, M. Peterson, J. Skinner, S. Dixit, Erin Kollins, Louis Huzella, Donna L. Perry, R. Byrum, Sanae Lembirik, Yi Zhang, E. Yang, Man Chen, K. Leung, R. Weinberg, A. Pegu, D. Geraghty, E. Davidson, I. Douagi, S. Moir, J. Yewdell, C. Schmaljohn, Peter D. Crompton, M. Holbrook, D. Nemazee, J. Mascola, I. Wilson, Joshua Tan   +41 more
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