Results 21 to 30 of about 304,289 (334)
Functional stability of HIV-1 envelope trimer affects accessibility to broadly neutralizing antibodies at its apex [PDF]
, 2017 The trimeric envelope glycoprotein spike (Env) of HIV-1 is the target of vaccine development to elicit broadly neutralizing antibodies (bnAbs). Env trimer instability and heterogeneity in principle make subunit interfaces inconsistent targets for the ...
Gift, Syna Kuriakose +4 more
core +2 more sources
Characterization of monoclonal and polyclonal antibodies to bovine enteric coronavirus: Establishment of an efficient ELISA for antigen detection in feces [PDF]
, 1989 Monoclonal antibodies to bovine enteric coronavirus (BEC) were produced. Additionally, polyclonal antibodies were made in rabbits and guinea pigs and extracted from the yolk of immunized hens.
Czerny, C. P., Eichhorn, Werner
core +1 more source
Isolation of Neutralizing Antibody
BIO-PROTOCOL, 2013 Use of monoclonal antibodies (MAbs) is an established laboratory strategy for characterization of specific pathogens and their antigenicity. Especially, Human MAbs (HuMAbs) with neutralizing activity against specific virus could have potential therapeutic application, and provide significant information on human epitopes that could be important for ...
Mayo Yasugi, Kazuyoshi Ikuta
openaire +3 more sources
Neutralizing Antibodies against SARS-CoV2
Medical Journal of Dr. D.Y. Patil Vidyapeeth, 2023 Coronavirus disease 2019 (COVID-19) is an illness due to a novel coronavirus which is Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Though this virus is recently identified in 2019, it is closely related to other coronaviruses namely SARS-
Prachi Athavale +4 more
doaj +1 more source
bNAber: database of broadly neutralizing HIV antibodies. [PDF]
, 2013 The discovery of broadly neutralizing antibodies (bNAbs) has provided an enormous impetus to the HIV vaccine research and to entire immunology. The bNAber database at http://bNAber.org provides open, user-friendly access to detailed data on the rapidly ...
Burton, Dennis R +8 more
core +4 more sources
Cross-reactive broadly neutralizing antibodies: timing is everything
Frontiers in Immunology, 2012 The recent surge of research into new broadly neutralizing antibodies in HIV-1 infection has recharged the field of HIV-1 vaccinology. In this review we discuss the currently known broadly neutralizing antibodies and focus on factors that may shape these
Zelda eEuler +2 more
doaj +1 more source
Antibody and Virus: Binding and Neutralization
Virology, 2000 During infection with an enveloped virus, antibodiesare elicited to envelope proteins. Some of these antibod-ies bind to envelope spikes on the virion, some bind tononvirion forms of the envelope (“viral debris”), and somebind to both. The relative amounts of different antibodytypes elicited varies from virus to virus.
Paul W. H. I. Parren +2 more
openaire +2 more sources
ZIKV Envelope Domain-Specific Antibodies: Production, Purification and Characterization
Viruses, 2019 Infection with Zika virus (ZIKV) came first to public attention after it was found to be associated with congenital microcephaly during the outbreak in Brazil (2015–2016). Diagnosis of ZIKV suffers from extensive cross-reactivity with other Flaviviruses,
Sami Akhras +4 more
doaj +1 more source
Broad and potent cross clade neutralizing antibodies with multiple specificities in the plasma of HIV-1 subtype C infected individuals. [PDF]
, 2017 Broadly Cross clade Neutralizing (BCN) antibodies are recognized as potential therapeutic tools and leads for the design of a vaccine that can protect human beings against various clades of Human Immunodeficiency Virus (HIV).
Ashokkumar, Manickam +12 more
core +3 more sources
Viruses, 2012 The immune response against some viral pathogens, in particular those causing chronic infections, is often ineffective notwithstanding a robust humoral neutralizing response.
Roberto Burioni +8 more
doaj +1 more source