Results 301 to 310 of about 312,346 (337)

Broadly neutralizing antibodies, nonneutralizing antibodies and broadly effector antibodies to prevent HIV transmission? [PDF]

AIDS
Van de Perre P, Moore PL, Nagot N, Gama L, Moles JP.   +4 more
europepmc   +1 more source

HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment

Advanced Science, EarlyView.
This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong, Yulong Li, Hui Liang, Zumei Wu, Shiqun Wang, Yichao Wang, Jieyu Xu, Yanning Lan, Maohua Cai, Guangzhao Pan, Haiyan Yang, Kai Miao, Zhe‐Sheng Chen, Fangfang Tao, Xuelei Ma, Jiang‐Jiang Qin   +15 more
wiley   +1 more source

Vaccination with an mRNA-encoded membrane-bound HIV envelope trimer induces neutralizing antibodies in animal models. [PDF]

Sci Transl Med
Ramezani-Rad P, Cottrell CA, Marina-Zárate E, Liguori A, Landais E, Torres JL, Myers A, Lee JH, Baboo S, Flynn C, McKenney K, Salcedo E, Zhou X, Kalyuzhniy O, Georgeson E, Phelps N, Lu D, Eskandarzadeh S, Menis S, Kubitz M, Groschel B, Alavi N, Jackson AM, Lee WH, Tran AS, Ben-Akiva E, Kaczmarek Michaels K, Diedrich JK, Enemuo CA, Lewis V, Pradhan A, Kasturi SP, Schiffner T, Steichen JM, Carnathan DG, Himansu S, Yates JR, Paulson JC, Ozorowski G, Irvine DJ, Silvestri G, Sok D, Ward AB, Crotty S, Schief WR.   +44 more
europepmc   +1 more source

Omicron KP.3 RBD-Containing Spike mRNA Vaccine Induces Broadly Neutralizing Antibodies with Protection Against SARS-CoV-2 Omicron Infection in Mice. [PDF]

Vaccines (Basel)
Guan X, Cho H, Qian S, Liu Q, Du L.
europepmc   +1 more source

Flavivirus-based bivalent nanoparticle vaccines induce neutralizing antibodies and Th1 responses against flavivirus and coupling antigens. [PDF]

iScience
Ii K, Sato F, Hatakeyama Y, Suzuki H, Noguchi T, Ishida K, Arakawa M, Nakamura K, Iwatsuki R, Nguyen CT, Yoshida A, Tanaka N, Tsunoda I, Ebina H, Morita E.   +14 more
europepmc   +1 more source

Mpox-Specific Neutralizing Antibodies up to 9 Months Following 1 or 2 Doses of Intradermal MVA-BN Vaccination in Sweden. [PDF]

Open Forum Infect Dis
Espinosa-Gongora C, Christ W, Mayola Danés N, Eichler-Jonsson C, Filén F, Storgärd E, Westergren V, Klingström J, Gredmark-Russ S, Johansen K, Ekström AM, Sondén K.   +11 more
europepmc   +1 more source

Neutralizing antibodies to SARS-CoV-2 variants of concern: a pediatric surveillance study. [PDF]

Sci Rep
Fraser DD, Singh D, Cela E, Patel MA, Assaf M, Quintero M, Knauer M, Miller MR, Bellini M, Li A, Hahn P, Hrek M, Cruz-Aguado J.   +12 more
europepmc   +1 more source

mRNA vaccine expressing enterovirus D68 virus-like particles induces potent neutralizing antibodies and protects against infection. [PDF]

Mol Ther Nucleic Acids
Kunishima Y, Senpuku K, Kataoka-Nakamura C, Hirai T, Yoshioka Y.   +4 more
europepmc   +1 more source

Discovery and characterization of potent broadly neutralizing antibodies from human survivors of severe fever with thrombocytopenia syndrome

Shuo Zhang, Hang Shang, Shuo Han, Jiachen Li, Xue‐Fang Peng, Yong‐Xiang Wu, Xin Yang, Yu Leng, Fei Wang, Ning Cui, Lingjie Xu, Hongkai Zhang, Yu Guo, Xiaoyu Xu, Nan Zhang, Wei Liu, Hao Li   +16 more
openalex   +1 more source

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Broadly Neutralizing Antiviral Antibodies

Annual Review of Immunology, 2013
A fascinating aspect of viral evolution relates to the ability of viruses to escape the adaptive immune response. The widely held view has been that the great variability of viral glycoproteins would be an absolute obstacle to the development of antibody-based therapies or vaccines that could confer broad and long-lasting protection.
Corti D., Lanzavecchia A.
openaire   +2 more sources