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Neutralization of HIV by Antibodies
2008Antibodies can neutralize HIV-1 with potency and cross-reactivity that varies widely and is related but not correlated to their antigen-binding affinity. Therefore, in addition to measuring binding affinity, an evaluation of the antibody neutralizing activity in tissue cultures is important for development of antibody-based therapeutics, design of ...
Ilia, Prado +2 more
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Sensitive neutralization test for virus antibody
Archives of Virology, 1978A sensitive mumps virus plaque neutralization test has been developed based on the potentiation of virus-antibody complexes by heterologous anti-immunoglobulins (AIG). The enhanced neutralization test was approximately 100 times more sensitive than the conventional neutralization test or the hemagglutination-inhibition test.
H, Sato +4 more
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Neutralization of Arenaviruses by Antibody
1987Neutralization of infectivity is the end result of a number of alternative or synergistic reactions between a virus and antibody directed against certain antigenic determinants on its surface. These reactions prevent either the attachment of virus to a particular host cell by steric hindrance, the entry of virus into the cell, or the uncoating of the ...
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Standardization of Poliovirus Neutralizing Antibody Tests
Clinical Infectious Diseases, 1984Recently the Forum for Advancement of Immunization Research sponsored a Collaborative Study on Poliovirus Antibody Titration. Twenty laboratories from 12 countries participated. There were considerable differences in detail of test performance and test results among laboratories.
P, Albrecht +3 more
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Cytokine-neutralizing therapeutic antibodies
2000Monoclonal antibodies (Mabs) offer the potential as useful therapeutic agents because of their high affinity and selectivity for the target antigen. The standard approach in making Mabs has been to immunise rodents, usually mice, with the desired human protein and generate a mouse anti-human IgG through hybridoma technology.
Amanda Suitters, Roly Foulkes
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HIV-Specific Neutralizing Antibodies
2001Infection with human immunodeficiency virus type 1 (HIV-1) generates cellular and humoral immune responses of various magnitudes to multiple virus-specific antigens. Perhaps the most beneficial B cell response is one that is directed against the surface gp120 and transmembrane gp41 envelope glycoproteins of the virus; both glycoproteins are major ...
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Phage Antibodies Neutralize Vaccinia Virus
Doklady Biochemistry and Biophysics, 2002N V, Tikunova +7 more
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