Results 331 to 340 of about 1,846,702 (390)

High-level adenovirus-neutralizing antibodies plasma beneficial for adenovirus type 7 (Adv7) induced pediatric severe ARDS. [PDF]

J Virus Erad
Chen F, Dang R, Zhao M, Chen Y, Huang J, Zuo Y, Yang Y.   +6 more
europepmc   +1 more source

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source

Distinct region-specific neutralization profiles of contemporary HIV-1 clade C against best-in-class broadly neutralizing antibodies. [PDF]

J Virol
Sutar J, Jayal P, Mullick R, Chaudhary S, Kamble P, Bhowmick S, Kaginkar S, Padwal V, Devadiga P, Neman N, Kitchin D, Kaldine H, Mkhize NN, Ndlovu B, Gounder K, Mukherjee S, Shrivas S, Sharma N, Prasad C, Tewatia S, Parihar N, Kumar N, Kasarpalkar N, Singh B, Mohapatra S, Aquil M, Kumar CV, Dinesha TR, Srikrishnan AK, Shastri J, Agrawal S, Gaikwad S, Mondal S, Bandyopadhyay B, Guha SK, Kale D, Biswas D, Patil D, Paranjape RS, Mukhopadhyay S, Hema, Das R, Kondapi A, Bhor V, Deshpande S, Sok D, Ndung'u T, Moore PL, Murugavel KG, Patel V, Bhattacharya J.   +50 more
europepmc   +1 more source

Inhalable Artificial Polymeric Nucleases Degrading Neutrophil Extracellular Trap‐DNAs and Alleviating Pulmonary Fibrosis

Advanced Science, EarlyView.
Pulmonary fibrosis (PF) is promoted by NETs that induce fibroblast activation. PEG‐PIm, a polymeric artificial DNase is reported that efficiently degrades NET‐DNA via phosphodiester bond hydrolysis. Inhalation of PEG‐PIm in a mouse PF model prevents fibroblast activation and fibrosis progression, offering a promising therapeutic strategy for NET ...
Yibo Du, Chenxu Zhu, Ruifeng Wang, Shi Chen, Chuang Li, Defang OuYang, Lixin Liu, Yongming Chen   +7 more
wiley   +1 more source

Cost-effectiveness of broadly neutralizing antibodies for HIV prophylaxis for infants born in settings with high HIV burdens. [PDF]

PLoS One
Alba C, Malhotra S, Horsfall S, Barnhart ME, Bekker A, Chapman K, Cunningham CK, Fast PE, Fouda GG, Freedberg KA, Goga A, Ghazaryan LR, Leroy V, Mann C, McCluskey MM, McFarland EJ, Muturi-Kioi V, Permar SR, Shapiro R, Sok D, Stranix-Chibanda L, Weinstein MC, Ciaranello AL, Dugdale CM.   +23 more
europepmc   +1 more source

Amplifying Anti‐Tumor Immune Responses via Mitochondria‐Targeting Near‐Infrared Photodynamic Therapy

Advanced Science, EarlyView.
Interfacial Nd3+‐triplet energy transfer enables direct activation of molecular triplets under near‐infrared (NIR) irradiation for reactive oxygen species (ROS) generation. Photodynamic therapy (PDT) exaggerates hypoxia, which initiates subsequent hypoxia‐activated chemotherapy.
Cheng‐Ao Li, Junjie Nan, Qingxuan Ye, Bingzhu Zheng, Xiaomeng Dai, Jingya Li, Feng Wang, Huimin Ma, Yu Cheng, Jian Ruan, Weijia Fang, Peng Zhao, Renren Deng, Dong Cen   +13 more
wiley   +1 more source

Xmas-NT: A Novel Two-Color Fluorescence Micro Neutralization Test for the Detection of Neutralizing Antibodies Against Monkeypox Virus. [PDF]

J Med Virol
Bodenstein C, Bourquain D, Nitsche A, Grossegesse M.   +3 more
europepmc   +1 more source

The Role of CAF‐derived Vitronectin in Promoting Colorectal Cancer Progression and Immunosuppression

Advanced Science, EarlyView.
Cancer‐associated fibroblast (CAF)‐derived VTN upregulates SLC6A8 expression in colorectal cancer (CRC) cells and macrophages through enhanced FAK phosphorylation. This modulation significantly increases the cellular uptake of creatine and ATP, promoting cancer progression and macrophage polarization.
Jiahua Yu, Mengxi Xiu, Shijun Yu, Zhiqin Chen, Yandong Li, Yong Gao   +5 more
wiley   +1 more source

Corrigendum: Transient proteolysis reduction of <i>Nicotiana benthamiana</i>-produced CAP256 broadly neutralizing antibodies using CRISPR/Cas9. [PDF]

Front Plant Sci
Singh AA, Pillay P, Naicker P, Alexandre K, Malatji K, Mach L, Steinkellner H, Vorster J, Chikwamba R, Tsekoa TL.   +9 more
europepmc   +1 more source

Heme/NADH Mimics Co‐Decorated Allosteric Capsules for Regulating Oxygen Activation and Upregulating Intracellular Methionine Depletion

Advanced Science, EarlyView.
Through modifying the switchable µ‐oxo bridged FeIII‐porphyrins moiety and NADH mimics into a metal‐organic capsule, multiple responsive manners for O2 activation, chemical oxygenation and metabolic transformation have been demonstrated for upregulating intracellular methionine depletion and accumulation of methionine sulfoxide to achieve effective ...
Chunming Ma, Yihao Zhang, Junkai Cai, Baotong Ding, Yang Jiao, Chunying Duan   +5 more
wiley   +1 more source