Results 11 to 20 of about 302,343 (188)

Neutralization of Diverse Human Cytomegalovirus Strains Conferred by Antibodies Targeting Viral gH/gL/pUL128-131 Pentameric Complex [PDF]

open access: yes, 2017
Human cytomegalovirus (HCMV) is the leading cause of congenital viral infection, and developing a prophylactic vaccine is of high priority to public health.
Adler, Stuart P.   +19 more
core   +3 more sources

Glutaraldehyde Cross-linking of HIV-1 Env Trimers Skews the Antibody Subclass Response in Mice

open access: yesFrontiers in Immunology, 2017
Well-ordered soluble HIV-1 envelope glycoprotein (Env) spike mimetics such as Native Flexibly Linked (NFL) trimers display high homogeneity, desired antigenicity, and high in vitro stability compared to previous generation soluble HIV-1 Env trimers ...
Martina Soldemo   +9 more
doaj   +1 more source

Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer

open access: yesNature Communications, 2018
Native-like soluble HIV envelope (Env) trimers are potential vaccine immunogens, and elimination of furin-dependence could provide a DNA-based alternative. Here, Sarkar et al.
Anita Sarkar   +13 more
doaj   +1 more source

Co-evolution of HIV Envelope and Apex-Targeting Neutralizing Antibody Lineage Provides Benchmarks for Vaccine Design

open access: yesCell Reports, 2018
Summary: Broadly neutralizing antibodies (bnAbs) targeting the HIV envelope glycoprotein (Env) typically take years to develop. Longitudinal analyses of both neutralizing antibody lineages and viruses at serial time points during infection provide a ...
Kimmo Rantalainen   +13 more
doaj   +1 more source

Measles virus glycoprotein-based lentiviral targeting vectors that avoid neutralizing antibodies [PDF]

open access: yes, 2012
Lentiviral vectors (LVs) are potent gene transfer vehicles frequently applied in research and recently also in clinical trials. Retargeting LV entry to cell types of interest is a key issue to improve gene transfer safety and efficacy.
Abel, Tobias   +5 more
core   +3 more sources

Expression of the murine cytomegalovirus glycoprotein H by recombinant vaccinia virus [PDF]

open access: yes, 1994
The sequence of the gene encoding glycoprotein H (gH) of murine cytomegalovirus (MCMV) strain Smith was determined and compared with the sequence of the gH of MCMV strain K181. Transcriptional analysis showed that gH is encoded by a large mRNA of 5.0 kb,
Koszinowski, Ulrich H.   +4 more
core   +1 more source

bNAber: database of broadly neutralizing HIV antibodies. [PDF]

open access: yes, 2013
The discovery of broadly neutralizing antibodies (bNAbs) has provided an enormous impetus to the HIV vaccine research and to entire immunology. The bNAber database at http://bNAber.org provides open, user-friendly access to detailed data on the rapidly ...
Burton, Dennis R   +8 more
core   +4 more sources

Cleavage-Independent HIV-1 Trimers From CHO Cell Lines Elicit Robust Autologous Tier 2 Neutralizing Antibodies

open access: yesFrontiers in Immunology, 2018
Native flexibly linked (NFL) HIV-1 envelope glycoprotein (Env) trimers are cleavage-independent and display a native-like, well-folded conformation that preferentially displays broadly neutralizing determinants.
Shridhar Bale   +21 more
doaj   +1 more source

Fusion of the molecular adjuvant C3d to cleavage-independent native-like HIV-1 Env trimers improves the elicited antibody response

open access: yesFrontiers in Immunology, 2023
An effective HIV vaccine likely requires the elicitation of neutralizing antibodies (NAbs) against multiple HIV-1 clades. The recently developed cleavage-independent native flexibly linked (NFL) envelope (Env) trimers exhibit well-ordered conformation ...
Shridhar Bale   +18 more
doaj   +1 more source

Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding

open access: yesNature Communications, 2017
Eliciting broadly neutralizing antibodies (bnAbs) is a primary HIV vaccine goal, but available immunogens expose epitopes for development of non-nAbs.
Daniel W. Kulp   +20 more
doaj   +1 more source

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