Results 11 to 20 of about 1,804,185 (380)

A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2

Science, 2020
Hitting SARS-CoV-2 in a new spot A key target for therapeutic antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the spike protein, a trimeric protein complex with each monomer comprising an S1 and an S2 domain that ...
Xiangyang Chi, R. Yan, Jun Zhang, Guanying Zhang, Yuanyuan Zhang, Meng Hao, Zhe Zhang, Pengfei Fan, Yunzhu Dong, Yilong Yang, Zhengshan Chen, Yingying Guo, Jinlong Zhang, Yaning Li, Xiaohong Song, Yi Chen, L. Xia, L. Fu, L. Hou, Junjie Xu, Changming Yu, Jianmin Li, Qiang Zhou, Wei Chen   +23 more
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The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates

Science Translational Medicine, 2021
LY-CoV555, a SARS-CoV-2 spike protein–specific antibody, neutralizes SARS-CoV-2 and protects the airways of nonhuman primates against infection. A monoclonal for SARS-CoV-2 Among the most promising therapeutic options for individuals with coronavirus ...
Bryan E. Jones, P. Brown-Augsburger, Kizzmekia S. Corbett, Kathryn Westendorf, J. Davies, T. Cujec, C. Wiethoff, J. Blackbourne, B. Heinz, Denisa Foster, R. Higgs, D. Balasubramaniam, Lingshu Wang, Yi Zhang, E. Yang, Roza Bidshahri, Lucas Kraft, Yuri Hwang, Stefanie Žentelis, Kevin R. Jepson, R. Goya, Maia A. Smith, D. W. Collins, Samuel J. Hinshaw, Sean A. Tycho, Davide Pellacani, Ping Xiang, Krithika Muthuraman, S. Sobhanifar, Marissa H. Piper, Franz J. Triana, J. Hendle, A. Pustilnik, A. Adams, Shawn J. Berens, R. Baric, David R. Martinez, R. Cross, T. Geisbert, V. Borisevich, O. Abiona, H. Belli, M. de Vries, Adil Mohamed, Meike Dittmann, M. Samanovic, M. Mulligan, J. Goldsmith, C. Hsieh, N. Johnson, D. Wrapp, J. McLellan, B. Barnhart, B. Graham, J. Mascola, C. Hansen, E. Falconer   +56 more
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Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus

Nature Communications, 2022
SIVmac239 infection of macaques is a favored model of human HIV infection, but antibody-mediated protection for SIVmac239 is insufficiently understood.
Fangzhu Zhao, Zachary T. Berndsen, Nuria Pedreño-Lopez, Alison Burns, Joel D. Allen, Shawn Barman, Wen-Hsin Lee, Srirupa Chakraborty, Sandrasegaram Gnanakaran, Leigh M. Sewall, Gabriel Ozorowski, Oliver Limbo, Ge Song, Peter Yong, Sean Callaghan, Jessica Coppola, Kim L. Weisgrau, Jeffrey D. Lifson, Rebecca Nedellec, Thomas B. Voigt, Fernanda Laurino, Johan Louw, Brandon C. Rosen, Michael Ricciardi, Max Crispin, Ronald C. Desrosiers, Eva G. Rakasz, David I. Watkins, Raiees Andrabi, Andrew B. Ward, Dennis R. Burton, Devin Sok   +31 more
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Vaccination induces HIV broadly neutralizing antibody precursors in humans

Science, 2022
Broadly neutralizing antibodies (bnAbs) can protect against HIV infection but have not been induced by human vaccination. A key barrier to bnAb induction is vaccine priming of rare bnAb-precursor B cells. In a randomized, double-blind, placebo-controlled
David J. Leggat, Kristen W. Cohen, Jordan R. Willis, W. Fulp, Allan C. deCamp, O. Kalyuzhniy, C. Cottrell, Sergey Menis, Greg Finak, Lamar Ballweber-Fleming, Abhinaya Srikanth, Jason R. Plyler, Torben Schiffner, Alessia Liguori, Farhad Rahaman, Angela Lombardo, V. Philiponis, Rachael E. Whaley, A. Seese, Joshua Brand, Alexis M Ruppel, W. Hoyland, N. Yates, L. D. Williams, Kelli M. Greene, Hongmei Gao, Celia Mahoney, M. Corcoran, A. Cagigi, Alison Taylor, David M. Brown, D. Ambrozak, Troy Sincomb, Xiaozhen Hu, Ryan Tingle, Erik Georgeson, Saman Eskandarzadeh, Nushin B Alavi, Danny Lu, T. Mullen, Michael Kubitz, Bettina Groschel, J. Maenza, O. Kolokythas, N. Khati, J. Bethony, S. Crotty, M. Roederer, G. K. Karlsson Hedestam, G. Tomaras, D. Montefiori, D. Diemert, R. Koup, D. Laufer, M. McElrath, A. McDermott, W. Schief   +56 more
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The diversity of the glycan shield of sarbecoviruses related to SARS-CoV-2

Cell Reports, 2023
Summary: Animal reservoirs of sarbecoviruses represent a significant risk of emergent pandemics, as evidenced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic.
Joel D. Allen, Dylan P. Ivory, Sophie Ge Song, Wan-ting He, Tazio Capozzola, Peter Yong, Dennis R. Burton, Raiees Andrabi, Max Crispin   +8 more
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SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19

New England Journal of Medicine, 2020
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (Covid-19), which is most frequently mild yet can be severe and life-threatening.
Peter Chen, A. Nirula, B. Heller, R. Gottlieb, J. Boscia, J. Morris, G. Huhn, Jose Cardona, Bharat Mocherla, V. Stosor, Imad Shawa, A. Adams, Jacob Van Naarden, Kenneth L Custer, Lei-Bin Shen, M. Durante, G. Oakley, A. Schade, J. Sabo, D. Patel, P. Klekotka, D. Skovronsky   +21 more
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Neutralizing antibody activity against 21 SARS-CoV-2 variants in older adults vaccinated with BNT162b2

Nature Microbiology, 2022
SARS-CoV-2 variants may threaten the effectiveness of vaccines and antivirals to mitigate serious COVID-19 disease. This is of most concern in clinically vulnerable groups such as older adults.
J. Newman, N. Thakur, T. Peacock, D. Bialy, A. Elrefaey, C. Bogaardt, D. Horton, S. Ho, T. Kankeyan, C. Carr, K. Hoschler, W. Barclay, G. Amirthalingam, K. Brown, B. Charleston, D. Bailey   +15 more
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Highly mutated antibodies capable of neutralizing N276 glycan-deficient HIV after a single immunization with an Env trimer

Cell Reports, 2022
Summary: Elicitation of HIV broadly neutralizing antibodies (bnAbs) is challenging because unmutated bnAb precursors are rare and seldom bind HIV envelope glycoprotein (Env) trimers.
Jeong Hyun Lee, Catherine Nakao, Michael Appel, Amber Le, Elise Landais, Oleksandr Kalyuzhniy, Xiaozhen Hu, Alessia Liguori, Tina-Marie Mullen, Bettina Groschel, Robert K. Abbott, Devin Sok, William R. Schief, Shane Crotty   +13 more
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IgA dominates the early neutralizing antibody response to SARS-CoV-2

Science Translational Medicine, 2020
Early specific antibody responses against SARS-CoV-2 include IgG, IgM, and IgA, but IgA may neutralize virus and control infection to a larger extent.
D. Sterlin, A. Mathian, M. Miyara, A. Mohr, François Anna, Laetitia Claër, Paul Quentric, J. Fadlallah, H. Devilliers, P. Ghillani, Cary Gunn, Rick Hockett, Sasi Mudumba, A. Guihot, C. Luyt, J. Mayaux, A. Beurton, S. Fourati, T. Bruel, O. Schwartz, J. Lacorte, H. Yssel, C. Parizot, K. Dorgham, P. Charneau, Z. Amoura, G. Gorochov   +26 more
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Epistasis lowers the genetic barrier to SARS-CoV-2 neutralizing antibody escape

bioRxiv, 2022
Waves of SARS-CoV-2 infection have resulted from the emergence of viral variants with neutralizing antibody resistance mutations. Simultaneously, repeated antigen exposure has generated affinity matured B cells, producing broadly neutralizing receptor ...
Leander Witte, Viren A. Baharani, F. Schmidt, Zijun Wang, A. Cho, Raphael Raspe, Camila Guzmán-Cardozo, F. Muecksch, Marie Canis, Debby J. Park, C. Gaebler, M. Caskey, M. Nussenzweig, T. Hatziioannou, P. Bieniasz   +14 more
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