Results 191 to 200 of about 300,221 (330)

Sero-neutralizing antibody against orthopoxviruses in populations of Wuhan, China. [PDF]

Mol Biomed
Gao Z, Liu T, Zhao Z, Wang B, Hou L.
europepmc   +1 more source

Protective effect of a germline, IL‐17‐neutralizing antibody in murine models of autoimmune inflammatory disease [PDF]

, 2014
Kiran Dallenbach, Patrik Maurer, Till A. Röhn, Franziska Zabel, Manfred Köpf, Martin F. Bachmann   +5 more
openalex   +1 more source

Post-fusion influenza vaccine adjuvanted with SA-2 confers heterologous protection via Th1-polarized, non-neutralizing antibody responses

, 2023
Ayae Nishiyama, Yu Adachi, Keisuke Tonouchi, Saya Moriyama, Lin Sun, M. Aoki, Hideki Asanuma, Masayuki Shirakura, Akihisa Fukushima, Takuya Yamamoto, Yoshimasa Takahashi   +10 more
openalex   +1 more source

Prickle4 Drives Microenvironmental Remodeling and Resistance to Parp Inhibition in IDH‐Mutant Glioma

Advanced Science, EarlyView.
IDH‐mutant gliomas exhibit sensitivity to PARP inhibitors (PARPi) owing to oncometabolite 2‐HG‐induced DNA repair defects. PARPi treatment induces resistance by upregulating Prickle4, which promotes VEGF‐driven angiogenesis. Combining PARPi veliparib with anti‐angiogenic lenvatinib blocks this pathway, causing tumor regression and prolonged survival in
Ju Yang, Hua Yang, Yifan Yuan, Chenyang Zhang, Ziwei Fu, Yanyan Chen, Yinghong Xiong, Shuyu Chen, Kexin Ling, Ying Liu, Jason T. Huse, Bo Chen, Timothy A. Chan, Zengxin Qi, Zhao Zhang, Xiuping Liu, Yuxiang Wang   +16 more
wiley   +1 more source

Precise targeting of HIV broadly neutralizing antibody precursors in humans. [PDF]

Science
Caniels TG, Prabhakaran M, Ozorowski G, MacPhee KJ, Wu W, van der Straten K, Agrawal S, Derking R, Reiss EIMM, Millard K, Turroja M, Desrosiers A, Bethony J, Malkin E, Liesdek MH, van der Veen A, Klouwens M, Snitselaar JL, Bouhuijs JH, Bronson R, Jean-Baptiste J, Gajjala S, Rikhtegaran Tehrani Z, Benner A, Ramaswami M, Duff MO, Liu YW, Sato AH, Kim JY, Baken IJL, Mendes Silva C, Bijl TPL, van Rijswijk J, Burger JA, Cupo A, Yasmeen A, Phulera S, Lee WH, Randall KN, Zhang S, Corcoran MM, Regadas I, Sullivan AC, Brown DM, Bohl JA, Greene KM, Gao H, Yates NL, Sawant S, Prins JM, Kootstra NA, Kaminsky SM, Barin B, Rahaman F, Meller M, Philiponis V, Laufer DS, Lombardo A, Mwoga L, Shotorbani S, Holman D, Koup RA, Klasse PJ, Karlsson Hedestam GB, Tomaras GD, van Gils MJ, Montefiori DC, McDermott AB, Hyrien O, Moore JP, Wilson IA, Ward AB, Diemert DJ, de Bree GJ, Andrews SF, Caskey M, Sanders RW.   +76 more
europepmc   +1 more source

Tie2‐Dependent Mechanisms Influence Leptomeningeal Collateral Dynamics and Reperfusion Following Stroke

Advanced Science, EarlyView.
This work demonstrates that endothelial EphA4 limits Tie2 activation and curbs leptomeningeal collateral expansion after ischemic stroke. Pharmacological activation of Tie2 by an Ang‐1 mimetic or genetic loss of EphA4 stimulates collateral vessel growth, improves cerebral perfusion, and enhances neurological recovery.
Alexandra M. Kaloss, Caroline de Jager, Kennedie Lyles, Nathalie A. Groot, Jackie Zhu, Yu Lin, Michael Chen, Hehuang Xie, John B. Matson, Michelle H. Theus   +9 more
wiley   +1 more source

Structures of vesicular stomatitis virus glycoprotein G alone and bound to a neutralizing antibody. [PDF]

PLoS Pathog
Minoves M, Ouldali M, Belot L, Roche S, Johari S, Noiray M, Zarkadas E, Schoehn G, Gaudin Y, Albertini AA.   +9 more
europepmc   +1 more source

Could anti-ACE2 antibodies alter the results of SARS-CoV-2 Ab neutralization assays?

, 2022
Raquel Tobes, Eduardo Pareja
openalex   +2 more sources

T Cell Glycoengineering to Modulate Immune‐Tumor Crosstalk: A Universal Non‐Genetic Strategy for Enhanced Tumor Immunotherapy

Advanced Science, EarlyView.
This study describes a T cell surface engineering strategy that integrates polymer materials with tumor immunology, aiming to achieve broad‐spectrum anti‐tumor applications of glycopolymer‐engineered T (G‐T) cells via non‐genetic modification. Glycopolymer engineering generally modulates immune‐tumor crosstalk through specific cell‐cell interactions ...
Lihua Yao, He Yang, Fangjian Shan, Xiaomeng Niu, Yichen Wang, Hengyuan Zhang, Sujian Wang, Gaojian Chen, Hong Chen   +8 more
wiley   +1 more source

Discovery and molecular mechanism of potent neutralizing antibody from humanized mice with respiratory syncytial virus. [PDF]

PLoS Pathog
Zhang Z, Feng R, Zhang L, Yang Q, Chen X, Wang X, Nie C, Peng W, Wang X, Zhu L, Guo Y, Sun Z.   +11 more
europepmc   +1 more source