Results 201 to 210 of about 300,221 (330)

TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition

Advanced Science, EarlyView.
This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Yanchen Zhang, Ende Wu, Weibin Liu, Ling Zeng, Neng Ling, Hongmei Wang, Zhixing Li, Shuang Yao, Tonghe Pan, Xuanwen Li, Yate Huang, Xiaojing Li, Yunhai Tu, Wentao Yan, Jianzhang Wu, Mao Ye, Wencan Wu   +16 more
wiley   +1 more source

Mechanism for evolution of diverse autologous antibodies upon broadly neutralizing antibody therapy of people with HIV. [PDF]

Cell Rep
Kannan D, Wang E, Deeks SG, Lewin SR, Chakraborty AK.   +4 more
europepmc   +1 more source

Neutralizing Antibody Responses and Evolution of the Viral Envelope in the Course of HIV-1 Korean Clade B Infection

, 2011
Bo Gyeong Shin, Mi-Ran Yun, Sung Soon Kim, Gab Jung Kim   +3 more
openalex   +1 more source

Stimulation of HIV-1-neutralizing antibodies in simian HIV-IIIB-infected macaques [PDF]

, 1998
Sybille Müller, David Margolin, Peter L. Nara, W. Gregory Alvord, Heinz Köhler   +4 more
openalex   +1 more source

Interferon‐Driven Biomarkers and Synergistic Therapy for PRMT5 Inhibition in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer exhibits variable sensitivity to PRMT5 inhibition. Basal interferon signaling is identified as a key biomarker of response. PARP inhibition with olaparib induces IFN signaling, sensitizing resistant TNBC cells to PRMT5 inhibitors.
Ziwen Zhang, Sheyu Zhang, Lu Guo, Yichun Pan, Juan Huang, Yishuai Ji, Jiaqi Tao, Yong Wei, Xiaojia Wang, Qin Wu   +9 more
wiley   +1 more source

Development of an Indirect ELISA Based on the PEDV S Protein and Evaluation of Its Correlation With Neutralizing Antibody and Immune Protection. [PDF]

Transbound Emerg Dis
Ma G, Hu G, Ren G, Ma W, Zhang S, Shen H, Liu Y, Li B.   +7 more
europepmc   +1 more source

Potent neutralization by a receptor binding domain monoclonal antibody with broad specificity for SARS-CoV-2 JN.1 and other variants

Michael S. Piepenbrink, Ahmed Magdy Khalil, Ana C. Chang, Ahmed Mostafa, Madhubanti Basu, Sanghita Sarkar, Simran Panjwani, Yaelyn H. Ha, Yao Ma, Chengjin Ye, Qian Wang, Todd J. Green, James L. Kizziah, Nathaniel Erdmann, Paul A. Goepfert, Lihong Liu, David D. Ho, Luis Martínez‐Sobrido, Mark R. Walter, James J. Kobie   +19 more
openalex   +2 more sources

Neutralizing antibodies against highly cytopathic Zairian human immunodeficiency type-1 virus (HIV-1) NDK are present in sera outside Africa

, 1995
Alcyone Artioli Machado, Mazangi Bakpabua, Danièle Salaün, Jean de Mareuil, Viktor Krchňák, Rob Roy MacGregor, Jean‐Claude Chermann, Ivan Hirsch   +7 more
openalex   +1 more source

Targeting Adipose Tissue Function Protects Against Heart Failure with Preserved Ejection Fraction

Advanced Science, EarlyView.
This study explores the role adipose tissue (AT) phenotypes have in determining cardiovascular outcomes in an obesity‐related heart failure with preserved ejection fraction (HFpEF) model. Pharmacological induction of thermogenesis promoted resilience to HFpEF‐induced remodeling of AT and conferred cardioprotection. Surgical and genetic models confirmed
Jordan Jousma, Zhenbo Han, Jooman Park, Gege Yan, Sen Zhang, Youjeong Kwon, Sarath Babu Nukala, Jindpreet Kandola, Sandra Pinho, Chong Wee Liew, Yuwei Jiang, Sang‐Ging Ong   +11 more
wiley   +1 more source

A broadly neutralizing antibody confers cross-genus protection against alphaherpesviruses by inhibiting gB-mediated membrane fusion. [PDF]

Nat Commun
Wang G, Li Y, Wu C, Chen T, Gui M, Zeng Y, Sun H, Chen K, Xi X, Yang Y, Jiang Y, Jiang Y, Liu L, Yang C, Xin J, Liu C, Li Y, Huo N, Huang Y, Lin L, Yu H, Huang C, Yuan Q, Li S, Tian K, Zheng Q, Xia N, Chen Y.   +27 more
europepmc   +1 more source