Results 221 to 230 of about 1,881,376 (382)

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

IgG3 snitcher of RSV infections in the very young [PDF]

, 2017
Saelens, Xavier, Schepens, Bert
core   +3 more sources

Neutralizing antibody evolution [PDF]

Nature Immunology, 2015
openaire   +1 more source

Platelet Rubicon Bidirectional Regulation of GPVI and Integrin αIIbβ3 Signaling Mitigates Stroke Infarction Without Compromising Hemostasis

Advanced Science, EarlyView.
This study identifies Rubicon as a key platelet protein that bidirectionally regulates GPVI and integrin αIIbβ3 signaling. Platelet Rubicon protects against cerebral ischemia‐reperfusion injury by limiting infarction without increasing hemorrhage.
Xiaoyan Chen, Jingke Li, Yangyang Liu, Li Li, Xin Deng, Yilin Sheng, Xianyu Zhu, Xiao Jiang, Wei Li, Xueli Cai, Qiming Sun, Hu Hu   +11 more
wiley   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

The Cost of Relapsing-Remitting Multiple Sclerosis Patients Who Develop Neutralizing Antibodies during Interferon Beta Therapy

, 2016
Damiano Paolicelli, Sergio Iannazzo, Laura Santoni, Antonio Iaffaldano, Valentina Di Lecce, Alessia Manni, Vito Lavolpe, Carla Tortorella, Mariangela D’Onghia, Vita Direnzo, Elisa Puma, María Trojano   +11 more
openalex   +2 more sources

Broadly neutralizing antibodies against COVID-19

, 2023
Daming Zhou, Jingshan Ren, Elizabeth E. Fry, David I. Stuart   +3 more
openalex   +1 more source

Prevalence of Zika virus neutralizing antibodies in healthy adults in Vietnam during and after the Zika virus epidemic season: a longitudinal population-based survey [PDF]

, 2020
Co Thach Nguyen, Meng Ling Moi, Thi Quynh Mai Le, Thi Thu Thuy Nguyen, Vu Thi Bich Hau, Hai Tuan Nguyen, Thi Thu Hang Pham, Thi Hien Thu Le, Le Manh Hung Nguyen, Minh Huong Phu Ly, Chris Fook Sheng Ng, Taichiro Takemura, Kouichi Morita, Futoshi Hasebe   +13 more
openalex   +1 more source

Regulating Tumor Metabolic Reprogramming with Biomimetic Co‐Delivery of Simvastatin and Kynureninase for Immunotherapy

Advanced Science, EarlyView.
After the intravenous injection of biomimetic and pH/ROS‐responsive PTSK@CRM, the nanoparticles can be accumulated in tumors and release Sim and KYNase to inhibit the tumor growth, regulate the metabolism of cholesterol and Kyn, and reverse the immunosuppressive tumor microenvironment.
Jiaxin Yin, Shengcai Yang, Zengguang Liu, Songchen Zhao, Siyu Sun, Ziling Liu, Quanshun Li   +6 more
wiley   +1 more source

Sustained Delivery of a Broadly Neutralizing Antibody in Nonhuman Primates Confers Long-Term Protection against Simian/Human Immunodeficiency Virus Infection [PDF]

, 2015
Kevin O. Saunders, Amarendra Pegu, Ivelin S. Georgiev, Ming Zeng, Michael Joyce, Zhi-Yong Yang, Sung‐Youl Ko, Xuejun Chen, Stephen D. Schmidt, Ashley T. Haase, John-Paul Todd, Saran Bao, Peter D. Kwong, Srinivas S. Rao, John R. Mascola, Gary J. Nabel   +15 more
openalex   +1 more source