Results 261 to 270 of about 289,586 (356)

PIEZO1‐GPX4 Axis Mediates Mechanical Stress‐Induced Vertebral Growth Plate Dysplasia via Ferroptosis Activation

Advanced Science, EarlyView.
Mechanical stress activates PIEZO1 in vertebral growth plate chondrocytes, triggering ferroptosis through direct binding and inhibition of GPX4. This axis promotes lipid peroxidation and pathological ossification, accelerating spinal deformities. Clinical and genetic evidence (Piezo1‐cKO) confirms its role in scoliosis progression.
Fei Chen, Fushuai Peng, Shuqing Chen, Yukun Du, Jianyi Li, Yuanyuan Fan, Zichen Cui, Guanghui Gu, Han Zhang, Zhensong Jiang, Guodong Wang, Xingzhi Jing, Jun Dong, Tao Li, Yongming Xi   +14 more
wiley   +1 more source

Stabilized dengue virus 2 envelope subunit vaccine redirects the neutralizing antibody response to all E-domains. [PDF]

J Virol
Thiono DJ, Samaras D, Phan TTN, Zhu DR, Shah RP, Castillo I, Forsberg LJ, Premkumar L, Baric RS, Tian S, Kuhlman B, de Silva AM.   +11 more
europepmc   +1 more source

LONG-TERM STUDIES ON NEUTRALIZING ANTIBODIES FOLLOWING VACCINATION WITH ATTENUATED LIVE POLIOVIRUS VACCINE AND THE EFFECT OF BOOSTER IMMUNIZATION

, 1963
KINKO TAKAI
openalex   +2 more sources

Long Term High‐Salt Diet Induces Cognitive Impairments via Down‐Regulating SHANK1

Advanced Science, EarlyView.
The study identifies a novel mechanistic link between long‐term HS diet and cognitive impairment, wherein PKA/CREB axis inactivation leads to SHANK1 reduction, synaptic damage, and cognitive deficits. Abstract High‐salt (HS) diet is an established risk factor for cognitive impairment, but the underlying mechanisms remain unclear.
Cuiping Guo, Yuanyuan Li, Wensheng Li, Tongrui Wu, Yi Liu, Yacoubou Abdoul Razak Mahaman, Jianzhi Wang, Rong Liu, Wei Liu, Hui Shen, Xiaochuan Wang   +10 more
wiley   +1 more source

Enhanced HIV-1 Neutralizing Antibody Breadth in HTLV-2 Co-Infected Individuals: Influence of Antiretroviral Regimen and B Cell Subset Distribution. [PDF]

Vaccines (Basel)
Yuste E, Ruiz-De-León MJ, Casado JL, Moreno A, Vivancos MJ, Pérez-Elías MJ, Dronda F, Quereda C, Sánchez-Merino V, Vallejo A.   +9 more
europepmc   +1 more source

EPIZOOTIOLOGICAL STUDY ON EPIZOOTIC-FEVER-LIKE DISEASE OF CATTLE BY MEANS OF NEUTRALIZATION TEST : IV. NEUTRALIZING ANTIBODY RESPONSE TO LYOPHILIZED LIVE VIRUS VACCINE

, 1964
M. Yamada
openalex   +2 more sources

Progastrin Promotes Colorectal Cancer Stem Cell‐Like Properties via the Receptor PZR

Advanced Science, EarlyView.
The tumor microenvironment supports colorectal cancer (CRC) progression by maintaining cancer stem cells (CSCs) through progastrin (PG). This study identifies Protein Zero‐Related protein (PZR) as an essential receptor for PG activity, promoting CSC‐like signaling via SHP2/SRC/β‐catenin.
Julie Nguyen, Marie Lafitte, Maud Barbery, Kevin Espie, Maya Jeitany, Romain Larive, Jihane Vitre, Conception Paul, Yvan Boublik, Elise Fourgous, Valérie Simon, Audrey Sirvent, Madeline Neiveyans, Steeve Thirard, Lucile Bansard, Morgan Maillard, Nathalie Coutry, Jacques Colinge, Philippe Jay, Pierre Martineau, Michael Hahne, Julie Pannequin, Serge Roche   +22 more
wiley   +1 more source

The Pseudotyped Replication-Deficient VSV with Spike from PEDV Induces Neutralizing Antibody Against PEDV. [PDF]

Vaccines (Basel)
Yi J, Luo H, Zhang K, Lv L, Li S, Jiang Y, Zhou Y, Wei Z, Liu C.   +8 more
europepmc   +1 more source

Rusults of a Neutralizing Antibody Survey on Immunized Pigs without Clinical Manifestation in Some Piggery Contaminated with Hog Cholera Virus

, 1965
Atsushi Kawakubo, Togo Samejima, Morimasa FUJINO, Mario MURAMATSU, Hirozo SONOYAMA, Yuichi Mori   +5 more
openalex   +2 more sources

Critical Role of IL1R2‐ENO1 Interaction in Inhibiting Glycolysis‐Mediated Pyroptosis for Protection Against Lethal Sepsis

Advanced Science, EarlyView.
The authors have discovered that intracellular interleukin 1 receptor 2 (IL1R2) negatively regulates pyroptosis and inflammation by inhibiting glycolysis in sepsis. Soluble IL1R2 is released from macrophages undergoing pyroptosis. IL1R2 acts as a novel negative regulator of glycolysis by interacting with enolase 1 (ENO1), thereby inhibiting gasdermin D
Chuyi Tan, Han Ma, Jespar Chen, Gaifeng Ma, Alok Jha, Sipin Tan, Yaxi Zhu, Meidong Liu, Ke Liu, Xianzhong Xiao, Monowar Aziz, Huan Chen, Ping Wang, Huali Zhang   +13 more
wiley   +1 more source