Results 281 to 290 of about 1,881,376 (382)

Neutralization Sensitivity of Human Immunodeficiency Virus Type 1 Primary Isolates to Antibodies and CD4-Based Reagents Is Independent of Coreceptor Usage [PDF]

, 1998
Alexandra Trkola, Tom Ketas, Vineet N. KewalRamani, Fred Endorf, James Μ. Binley, Hermann Katinger, Jim Robinson, Dan R. Littman, John P. Moore   +8 more
openalex   +1 more source

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

The N terminus of H3-influenza hemagglutinin as a site-of-vulnerability to neutralizing antibody. [PDF]

Structure
Rawi R, Morano NC, Cheung CS, Du H, Gorman J, Prabhakaran M, Becker JE, Bylund T, Charaf S, Chen X, Lee M, Harris DR, Olia AS, Ou L, Wang L, Wang S, Zhang B, Kanekiyo M, McDermott AB, Zhou T, Shapiro L, Kwong PD.   +21 more
europepmc   +1 more source

eLife Assessment: Parallel HIV-1 fitness landscapes shape viral dynamics in humans and macaques that develop broadly neutralizing antibodies

Anne‐Florence Bitbol
openalex   +1 more source

Primary Virus Envelope Cross-Reactivity of the Broadening Neutralizing Antibody Response during Early Chronic Human Immunodeficiency Virus Type 1 Infection [PDF]

, 1999
Pengfei Zhang, Xi Chen, Da Wei Fu, Joseph B. Margolick, Gerald V. Quinnan   +4 more
openalex   +1 more source

Intercellular Horizontal Transfer of TXNDC5 mRNA via Extracellular Vesicles Contributes to Tumor‐Associated Macrophage‐Mediated Prostate Cancer Metastasis

Advanced Science, EarlyView.
This study investigates the role of M2 macrophage‐derived extracellular vesicles (M2 EVs) in prostate cancer (PCa) metastasis. Mechanistically, M2 EVs horizontally transfer TXNDC5 mRNA to PCa cells, where the molecule induces the mesenchymal‐like state (MLS), enhancing PCa migration and invasion.
Cong Hu, Tianyang Wu, Jiayi Wang, Xinxing Du, Xinrui Wu, Yanhao Dong, Zehong Peng, Penghui Liao, Zirui Guo, Zheyu Liu, Kenneth J Pienta, Yinjie Zhu, Jiahua Pan, Liang Dong, Wei Xue   +14 more
wiley   +1 more source

Broadly neutralizing antibody responses in a Chinese acute HIV-1 infection cohort of men who have sex with men. [PDF]

PLoS Pathog
Yao L, Gao Y, Tian W, Ding H, Shang H, Han X.   +5 more
europepmc   +1 more source

HETEROGENEITY IN LEVELS OF SERUM NEUTRALIZING ANTIBODIES AGAINST VIRAL HEMORRHAGIC SEPTICEMIA VIRUS GENOTYPE IVB AMONG FISH SPECIES IN LAKE ST. CLAIR, MICHIGAN, USA [PDF]

, 2012
Elena V. Millard, Mohamed Faisal
openalex   +1 more source

Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

Advanced Science, EarlyView.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu, Shengxia Yin, Wei An, Xia Lu, Qianwen Zhao, Jie Li   +14 more
wiley   +1 more source

Complete neutralizing antibody evasion by serodivergent non-mammalian AAVs enables gene therapy redosing. [PDF]

Cell Rep Med
Loeb EJ, Fergione SA, Yudistyra V, Fanous MM, Benkert AR, Fisher DG, Hull JA, ElMallah MK, Asokan A.   +8 more
europepmc   +1 more source