Results 21 to 30 of about 1,804,185 (380)

Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses

Journal of Experimental Medicine, 2020
The emergence of SARS-CoV-2 has created a need for robust assays of plasma and monoclonal antibody neutralization potency. Pseudotyped HIV-1– and vesicular stomatitis virus–based reporter viruses and a replication-competent vesicular stomatitis virus ...
F. Schmidt, Y. Weisblum, F. Muecksch, Hans-Heinrich Hoffmann, E. Michailidis, Julio C. C. Lorenzi, Pilar Mendoza, Magda Rutkowska, Eva Bednarski, C. Gaebler, Marianna Agudelo, A. Cho, Zijun Wang, A. Gazumyan, M. Cipolla, M. Caskey, D. Robbiani, M. Nussenzweig, C. Rice, T. Hatziioannou, P. Bieniasz   +20 more
semanticscholar   +2 more sources

Efficient isolation of rare B cells using next-generation antigen barcoding

Frontiers in Cellular and Infection Microbiology, 2023
The ability to efficiently isolate antigen-specific B cells in high throughput will greatly accelerate the discovery of therapeutic monoclonal antibodies (mAbs) and catalyze rational vaccine development.
Jonathan Hurtado, Jonathan Hurtado, Jonathan Hurtado, Claudia Flynn, Claudia Flynn, Claudia Flynn, Jeong Hyun Lee, Jeong Hyun Lee, Jeong Hyun Lee, Eugenia C. Salcedo, Eugenia C. Salcedo, Eugenia C. Salcedo, Christopher A. Cottrell, Christopher A. Cottrell, Christopher A. Cottrell, Christopher A. Cottrell, Patrick D. Skog, Dennis R. Burton, Dennis R. Burton, Dennis R. Burton, Dennis R. Burton, David Nemazee, William R. Schief, William R. Schief, William R. Schief, William R. Schief, William R. Schief, Elise Landais, Elise Landais, Elise Landais, Devin Sok, Devin Sok, Devin Sok, Bryan Briney, Bryan Briney, Bryan Briney, Bryan Briney   +36 more
doaj   +1 more source

Kinetics of the neutralizing antibody response to respiratory syncytial virus infections in a birth cohort [PDF]

, 2013
The kinetics of respiratory syncytial virus (RSV) neutralizing antibodies following birth, primary and secondary infections are poorly defined. The aims of the study were to measure and compare neutralizing antibody responses at different time points in ...
Cane, Patricia, Medley, Graham, Mutunga, M. N., Nokes, D. James, Okiro, Emelda A., Sande, Charles J.   +5 more
core   +1 more source

Cleavage-Independent HIV-1 Env Trimers Engineered as Soluble Native Spike Mimetics for Vaccine Design

Cell Reports, 2015
Viral glycoproteins mediate entry by pH-activated or receptor-engaged activation and exist in metastable pre-fusogenic states that may be stabilized by directed rational design. As recently reported, the conformationally fixed HIV-1 envelope glycoprotein
Shailendra Kumar Sharma, Natalia de Val, Shridhar Bale, Javier Guenaga, Karen Tran, Yu Feng, Viktoriya Dubrovskaya, Andrew B. Ward, Richard T. Wyatt   +8 more
doaj   +1 more source

Platelet-collagen adhesion: evidence for participation of antigenically distinct entities. [PDF]

, 1984
Univalent antibody fragments prepared from a rabbit antiserum raised against whole human platelets completely inhibited adhesion of platelets to immobilized trimeric collagen in a defined, Mg2+-dependent, adhesion assay.
Barondes, SH, Shadle, PJ
core   +2 more sources

Infection and vaccine-induced neutralizing antibody responses to the SARS-CoV-2 B.1.617.1 variant

bioRxiv, 2021
SARS-CoV-2 has caused a devastating global pandemic. The recent emergence of SARS-CoV-2 variants that are less sensitive to neutralization by convalescent sera or vaccine-induced neutralizing antibody responses has raised concerns.
V. Edara, L. Lai, M. Sahoo, K. Floyd, M. Sibai, D. Solis, Maria W Flowers, L. Hussaini, C. Ciric, Sarah Bechnack, Kathy Stephens, E. Mokhtari, P. Mudvari, A. Creanga, A. Pegu, Alexandrine Derrien-Colemyn, Amy R. Henry, M. Gagne, B. Graham, J. Wrammert, D. Douek, E. Boritz, B. Pinsky, M. Suthar   +23 more
semanticscholar   +1 more source

Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies

Cell Reports, 2016
A major advance in the search for an HIV vaccine has been the development of a near-native Envelope trimer (BG505 SOSIP.664) that can induce robust autologous Tier 2 neutralization.
Laura E. McCoy, Marit J. van Gils, Gabriel Ozorowski, Terrence Messmer, Bryan Briney, James E. Voss, Daniel W. Kulp, Matthew S. Macauley, Devin Sok, Matthias Pauthner, Sergey Menis, Christopher A. Cottrell, Jonathan L. Torres, Jessica Hsueh, William R. Schief, Ian A. Wilson, Andrew B. Ward, Rogier W. Sanders, Dennis R. Burton   +18 more
doaj   +1 more source

Neutralizing antibody responses to SARS-CoV-2 in a COVID-19 recovered patient cohort and their implications

medRxiv, 2020
Background The COVID-19 pandemic caused by SARS-CoV-2 coronavirus threatens global public health. Currently, neutralizing antibodies (NAbs) versus this virus are expected to correlate with recovery and protection of this disease.
Fan Wu, Aojie Wang, Mei Liu, Qimin Wang, Jun Chen, Shuai Xia, Y. Ling, Yuling Zhang, Jingna Xun, Lu Lu, Shibo Jiang, Hongzhou Lu, Y. Wen, Jinghe Huang   +13 more
semanticscholar   +1 more source

A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike protein

Nature Communications, 2021
Vaccines and therapeutics are urgently needed for the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we screen human monoclonal antibodies (mAb) targeting the receptor binding domain (RBD) of the viral spike ...
Cheolmin Kim, Dong-Kyun Ryu, Jihun Lee, Young-Il Kim, Ji-Min Seo, Y. Kim, Jae-Hee Jeong, Minsoo Kim, Jong-In Kim, P. Kim, J. Bae, E. Shim, M. Lee, Man Su Kim, H. Noh, Geun-Soo Park, Jae Sang Park, Dain Son, Yongjin An, Jeong No Lee, K. Kwon, Joo-Yeon Lee, Hansaem Lee, Jeong-Sun Yang, Kyung-Chang Kim, S. S. Kim, Hye-Min Woo, Jun-Won Kim, Man-Seong Park, Kwang-Min Yu, Se-Mi Kim, Eun-Ha Kim, Su-Jin Park, S. Jeong, C. Yu, Y. Song, S. Gu, H. Oh, Bon-Sang Koo, J. Hong, C. Ryu, W. Park, M. Oh, Y. Choi, Soo-Young Lee   +44 more
semanticscholar   +1 more source

Neutralization of Diverse Human Cytomegalovirus Strains Conferred by Antibodies Targeting Viral gH/gL/pUL128-131 Pentameric Complex [PDF]

, 2017
Human cytomegalovirus (HCMV) is the leading cause of congenital viral infection, and developing a prophylactic vaccine is of high priority to public health.
Adler, Stuart P., An, Zhiqiang, DePhillips, Pete A., Freed, Daniel C., Fu, Tong-Ming, Ha, Sha, Hamm, Melissa, Li, Fengsheng, Loughney, John W., McLellan, Jason S., McVoy, Michael A., Nickle, David C., Rustandi, Richard R., Tang, Aimin, Troutman, Matthew C., Vlasak, Josef, Wang, Dai, Wang, I-Ming, Zhang, Ningyan, Zhu, Hua   +19 more
core   +3 more sources