Results 71 to 80 of about 1,804,185 (380)

Review of therapeutic mechanisms and applications based on SARS-CoV-2 neutralizing antibodies

Frontiers in Microbiology, 2023
COVID-19 pandemic is a global public health emergency. Despite extensive research, there are still few effective treatment options available today. Neutralizing-antibody-based treatments offer a broad range of applications, including the prevention and ...
Mingtao Liu, Hui Gan, Zhiman Liang, Li Liu, Qiwen Liu, Yiyin Mai, Huihuang Chen, Baoying Lei, Shangwei Yu, Huihui Chen, Peiyan Zheng, Baoqing Sun   +11 more
doaj   +1 more source

The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine Template

Cell Reports, 2019
Summary: Epitope-targeted HIV vaccine design seeks to focus antibody responses to broadly neutralizing antibody (bnAb) sites by sequential immunization.
Raiees Andrabi, Jesper Pallesen, Joel D. Allen, Ge Song, Jinsong Zhang, Natalia de Val, Gavin Gegg, Katelyn Porter, Ching-Yao Su, Matthias Pauthner, Amanda Newman, Hilary Bouton-Verville, Fernando Garces, Ian A. Wilson, Max Crispin, Beatrice H. Hahn, Barton F. Haynes, Laurent Verkoczy, Andrew B. Ward, Dennis R. Burton   +19 more
doaj   +1 more source

Insights into neutralization of animal viruses gained from study of influenza virus [PDF]

, 1991
It has long been known that the binding of antibodies to viruses can result in a loss of infectivity, or neutralization, but little is understood of the mechanism or mechanisms of this process.
Colonno, Dimmock, Eisenlohr, Kennedy-Stoskopf, Kjellen, Kukuhara, Lamb, M. C. Outlaw, Mandel, Mandel, Mandel, McClure, N. J. Dimmock, Svehag, Thomas, Thomas, Viitala, Wharton   +17 more
core   +2 more sources

NEUTRALIZING ANTIBODIES IN ABORTIVE POLIOMYELITIS [PDF]

Journal of Experimental Medicine, 1933
The neutralizing antibody content for poliomyelitis virus has been tested with both a human and a passage strain of the virus in serial samples of sera from five mild cases of abortive poliomyelitis, and an increase in this antibody content has been demonstrated in convalescent samples obtained within 4 weeks of the acute illness.
John R. Paul, James D. Trask
openaire   +3 more sources

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Dynamics of Neutralizing Antibody Titers in the Months After Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Journal of Infectious Diseases, 2020
Most individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) develop neutralizing antibodies that target the viral spike protein.
K. H. Crawford, A. Dingens, Rachel T. Eguia, C. Wolf, Naomi C Wilcox, J. Logue, Kiel Shuey, A. Casto, B. Fiala, Samuel P Wrenn, D. Pettie, N. King, A. Greninger, H. Chu, J. Bloom   +14 more
semanticscholar   +2 more sources

Structure-Guided Redesign Improves NFL HIV Env Trimer Integrity and Identifies an Inter-Protomer Disulfide Permitting Post-Expression Cleavage

Frontiers in Immunology, 2018
Soluble HIV-1 envelope glycoprotein (Env) trimers are under active investigation as vaccine candidates in relevant pre-clinical models. Like SOSIPs, the cleavage-independent native flexibly linked (NFL) trimers are faithful mimics of the Env spike. Here,
Lifei Yang, Shailendra Kumar Sharma, Christopher Cottrell, Javier Guenaga, Karen Tran, Richard Wilson, Anna-Janina Behrens, Max Crispin, Max Crispin, Max Crispin, Natalia de Val, Richard T. Wyatt, Richard T. Wyatt, Richard T. Wyatt   +13 more
doaj   +1 more source

Expression of the murine cytomegalovirus glycoprotein H by recombinant vaccinia virus [PDF]

, 1994
The sequence of the gene encoding glycoprotein H (gH) of murine cytomegalovirus (MCMV) strain Smith was determined and compared with the sequence of the gH of MCMV strain K181. Transcriptional analysis showed that gH is encoded by a large mRNA of 5.0 kb,
Koszinowski, Ulrich H., Loh, Lambert C., Lucin, Pero, Messerle, Martin, Rapp, Maria   +4 more
core   +1 more source

Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection

Science immunology, 2020
Understanding the nature of immunity following mild/asymptomatic infection with SARS-CoV-2 is crucial to controlling the pandemic. We analyzed T cell and neutralizing antibody responses in 136 healthcare workers (HCW) 16-18 weeks after United Kingdom ...
C. Reynolds, Leo Swadling, J. Gibbons, C. Pade, M. Jensen, M. Diniz, N. Schmidt, D. Butler, O. E. Amin, S. N. L. Bailey, Sam M. Murray, F. Pieper, Stephen Taylor, Jessica Jones, Meleri Jones, W. Lee, J. Rosenheim, A. Chandran, G. Joy, C. Di Genova, Nigel J. Temperton, J. Lambourne, T. Cutino-Moguel, M. Andiapen, M. Fontana, A. Smit, A. Semper, B. O’Brien, B. Chain, T. Brooks, C. Manisty, T. Treibel, J. Moon, M. Noursadeghi, D. Altmann, M. Maini, Á. McKnight, R. Boyton   +37 more
semanticscholar   +1 more source

Sex Disparities and Neutralizing-Antibody Durability to SARS-CoV-2 Infection in Convalescent Individuals

Msphere, 2021
In this study, we found that neutralizing antibody responses in COVID-19-convalescent individuals vary in magnitude but are durable and correlate well with receptor binding domain (RBD) Ig binding antibody levels compared to other SARS-CoV-2 antigen ...
A. Markmann, Natasa Giallourou, D. Bhowmik, Yixuan J. Hou, A. Lerner, David R. Martinez, L. Premkumar, H. Root, D. van Duin, S. Napravnik, S. Graham, Quique Guerra, R. Raut, C. Petropoulos, T. Wrin, C. Cornaby, J. Schmitz, J. Kuruc, S. Weiss, Yara Park, R. Baric, A. D. de Silva, D. Margolis, L. Bartelt   +23 more
semanticscholar   +1 more source