Results 121 to 130 of about 18,856 (260)

A Personal Perspective on Metalloprotein Structure and the Future of Macromolecular X‐Ray Crystallography

open access: yesJournal of the Chinese Chemical Society, EarlyView.
While X‐ray crystallography has been the primary method for determining the structures of metalloproteins, cryoEM has taken over this role, illustrated by [4Fe4S]‐cluster containing proteins deposited in the Protein Data Bank. What will be the role for X‐ray crystallography as cryoEM and machine learning methods dominate the initial structural analysis?
Douglas C. Rees
wiley   +1 more source

Decoupling glacier retreat and surface stabilization on the Snežnik Plateau (Slovenia), insights from in situ cosmogenic 36Cl exposure and depth‐profile ages

open access: yesJournal of Quaternary Science, EarlyView.
ABSTRACT Glaciokarst landscapes pose distinctive challenges for cosmogenic dating because meltwater and runoff can be rapidly rerouted into ponors and conduit networks, weakening glacier–river coupling and promoting local sediment storage. We reconstruct glacier retreat and postglacial stabilization on the Snežnik Plateau (SW Slovenia) using in situ ...
Onur Altınay   +6 more
wiley   +1 more source

New geochronological constraints on Late Pleistocene glaciation in the southern Cadí Massif, SE Pyrenees

open access: yesJournal of Quaternary Science, EarlyView.
ABSTRACT The Cadí Massif (42°17′09″ N, 1°38′11″ E; 2649 m a.s.l.) in the southeastern Pyrenees preserves clear evidence of Late Pleistocene glaciation, although previous research has focused almost exclusively on its northern slope. By contrast, the southern slope has remained largely unexplored.
M. Oliva   +5 more
wiley   +1 more source

When Fat Goes Astray: Your Liver and Pancreas Get Into Trouble

open access: yesPortal Hypertension &Cirrhosis, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) and intrapancreatic fat deposition (IPFD) are both common manifestations of ectopic fat accumulation. Although they share multiple risk factors, they also show notable differences in pathological features, standardization of diagnosis, and research maturity.
Yuying Chen   +5 more
wiley   +1 more source

Multi-organ acute and delayed effects following exposure to neutron radiation. [PDF]

open access: yesiScience
Gasperetti T   +15 more
europepmc   +1 more source

Study of the neutron radiation hardness of MAPD-3NK2 silicon photomultipliers. [PDF]

open access: yesSci Rep
Ahmadov F   +13 more
europepmc   +1 more source

Safety, efficacy, pharmacokinetics, and mechanisms of novel 10B‐boronophenylalanine combined with a radio‐frequency quadrupole accelerator in boron neutron capture therapy: A preclinical study in head and neck squamous cell carcinoma

open access: yesPrecision Radiation Oncology, EarlyView.
This study demonstrates that the novel 10B‐BPA‐based BNCT system, combined with an RFQ accelerator, effectively targets head and neck squamous cell carcinoma. It induces tumor regression safely and efficiently by triggering DNA damage and activating the ROS/HIF‐1α/NF‐κB pathway, leading to caspase‐3‐mediated apoptosis.
Zhaoyuan Zhang   +13 more
wiley   +1 more source

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