Results 121 to 130 of about 277,862 (386)
Promising Prodiginins Biological Activities
ABSTRACT Prodiginins are a large family of at least 34 pyrrolic compounds, including the well‐studied red pigment prodigiosin. Prodiginins are produced by several microorganisms displaying broad biological activities, including antimicrobial, antiviral, antiparasitic, antiproliferative, and immunosuppressive activities.
María F. Ladetto+6 more
wiley +1 more source
Introduction: Febrile neutropenia is a life-threatening condition that is the most common oncological emergency, especially in cases of hematological cancer. Knowledge related to this condition can accelerate treatment and reduce mortality. The danger of
Agus Suryaman
doaj +1 more source
Mechanism-based model characterizing bidirectional interaction between PEGylated liposomal CKD-602 (S-CKD602) and monocytes in cancer patients [PDF]
S-CKD602 is a PEGylated liposomal formulation of CKD-602, a potent topoisomerase I inhibitor. The objective of this study was to characterize the bidirectional pharmacokinetic-pharmacodynamic (PK-PD) interaction between S-CKD602 and monocytes.
Bang YJ+12 more
core +2 more sources
PURPOSE To validate a prognostic score predicting major complications in patients with solid tumors and seemingly stable episodes of febrile neutropenia (FN). The definition of clinical stability implies the absence of organ dysfunction, abnormalities in
A. Carmona-Bayonas+26 more
semanticscholar +1 more source
Abstract Berzosertib is a small‐molecule ataxia telangiectasia and Rad3‐related protein inhibitor. To assess the clearance mechanism(s) of berzosertib, a Phase 1, 2‐period, open‐label study was conducted in adults with advanced solid tumors who were treated with a single intravenous dose of 210 mg/m2 berzosertib containing approximately 3 µCi of [14C ...
Jayaprakasam Bolleddula+12 more
wiley +1 more source
Background and Objectives: In clinical practice, neutropenia is frequently accompanied by other cytopenia; isolated non-chemotherapy-induced severe neutropenia is less frequent and its differential diagnosis can be challenging.
Linet Njue+5 more
doaj +1 more source
Epidemiology and potential preventative measures for viral infections in children with malignancy and those undergoing hematopoietic cell transplantation. [PDF]
In pediatric patients with malignancy and those receiving hematopoietic stem cell transplants, bacterial and fungal infections have been the focus of fever and neutropenia episodes for decades.
Alexander, Sarah+5 more
core +1 more source
Pemetrexed is a cornerstone in chemo(immunotherapy) of non‐small cell lung cancer and mesothelioma; however, it is contraindicated in patients with renal impairment due to severe toxicity concerns. Therefore, a large proportion of patients is withheld from effective chemo(immunotherapy).
Nikki de Rouw+18 more
wiley +1 more source
Screening of the central nervous system in children with invasive pulmonary aspergillosis [PDF]
Peer reviewedPublisher ...
Broenen, Emmi+5 more
core +2 more sources
Background:Metastatic renal cell carcinoma (mRCC) prognostic models may be improved by incorporating treatment-induced toxicities.Methods:In sunitinib-treated mRCC patients (N=770), baseline prognostic factors and treatment-induced toxicities ...
F. Donskov+10 more
semanticscholar +1 more source