Results 121 to 130 of about 209,210 (339)
ABSTRACT Background Adenoid cystic carcinoma (ACC) is the second most common and treatment‐resistant salivary gland carcinoma (SGC). Although platinum‐based therapies are effective, the efficacy of eribulin, a microtubule inhibitor with an 18% response rate in a Phase II trial involving recurrent/metastatic SGC, in patients with advanced ACC after ...
Tomomi Sanomachi+16 more
wiley +1 more source
Aims and Objectives: To know the various parameters and diagnostic approach of megaloblastic anemia. To know the age incidence and sex ratio. Materials and Methods: A hospital-based retrospective and prospective study was done for a period of 1-year ...
S Srikanth
doaj +1 more source
Osteomyelitis: an unusual sequel to neutropenia. [PDF]
L. R. I. Baker+3 more
openalex +1 more source
ABSTRACT Background In Europe, pembrolizumab with or without chemotherapy is the recommended first‐line treatment for recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC), with a combined positive score (CPS) ≥ 1. In France, the TPExtreme (TPEx) regimen is preferred for CPS < 1.
Alizée Simon+6 more
wiley +1 more source
Normal Granulocyte Colony-forming Cells in the Bone Marrow of Yemenite Jews With Genetic Neutropenia [PDF]
Uri Mintz, Leo Sachs
openalex +1 more source
ABSTRACT Background Optimal feeding strategy (Prophylactic vs. Reactive) during Radiation Therapy (RT) for Head and Neck Cancers (HNC) remains to be established. Methods This phase III trial randomized (1:1) patients of HNC to prophylactic [nasogastric tube (NGT) placed at least 1 day before RT starting] versus reactive arm (NGT when required).
Sarbani Ghosh Laskar+21 more
wiley +1 more source
Targeting the Menin–KMT2A interaction in leukemia: Lessons learned and future directions
Abstract Chromosomal rearrangements involving the Mixed Lineage Leukemia gene (MLL1, KMT2A) are defining a genetically distinct subset in about 10% of human acute leukemias. Translocations involving the KMT2A‐locus at chromosome 11q23 are resulting in the formation of a chimeric oncogene, where the N‐terminal part of KMT2A is fused to a variety of ...
Florian Perner+3 more
wiley +1 more source
Cyclic Neutropenia: The Relationship Between Urine Granulocyte Colony Stimulating Activity and Neutrophil Count [PDF]
Aroop Mangalik, William A. Robinson
openalex +1 more source
Therapeutic targeting of chromatin alterations in leukemia and solid tumors
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner+7 more
wiley +1 more source
Chronic neutropenia in childhood: experience of a tertiary center
Objective: To assess the prevalence of chronic neutropenia (CN) and the clinical profile of patients with CN aged up to 18 years, followed in the pediatric hematology, rheumatology, or immunology outpatient clinic of a tertiary medical center from May 1,
Letícia Matushita+5 more
doaj