Neutropenia, agranulocytosis and dipyrone [PDF]
Sao Paulo Medical Journal, 2005 CONTEXT: Neutropenia and agranulocytosis may be defined as granulocyte counts of less than 1,500/mm³ and 500/mm³, respectively. Agranulocytosis is a rare and serious disease often caused by drugs. Its mortality rate is around 10%. The most common manifestations are infections such as tonsillitis, pharyngitis, stomatitis or pneumonia.
Hamerschlak, Nelson +1 more
openaire +6 more sources
Mechanisms of leukemic transformation in congenital neutropenia
Current opinion in hematology, 2019 Purpose of review The development of a myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) in patients with congenital neutropenia is now the major cause of mortality.
D. Link
semanticscholar +1 more source
Two Cases of Vancomycin-Induced Neutropenia
Pharmacy(1) Background: The incidence of vancomycin-induced neutropenia in hospitalized patients is estimated to be around 2 to 8 percent Data surrounding vancomycin-induced neutropenia is limited as it is based on a small number of observational case reports ...
Kirsten Ganaja +2 more
doaj +1 more source
European surveillance of infections in cancer patients - ESIC [PDF]
, 1999 Major advances in cancer therapy result from development of multidrug chemotherapy regimens. Besides death from tumor progression, infections are currently one of the major causes of mortality and morbidity.
Buchheidt, D. +7 more
core +1 more source
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
KEJADIAN DEMAM NEUTROPENIA PADA PASIEN KANKER PAYUDARA YANG MENDAPAT KEMOTERAPI
Majalah Kedokteran Andalas, 2015 AbstrakKemoterapi memiliki peranan penting dalam penatalaksanaan kanker payudara. Obat ini bekerjamembunuh sel-sel kanker, namun dapat juga menghancurkan sel-sel sehat termasuk sel darahsehingga dapat menyebabkan neutropenia.
Rulli Firmansyah +3 more
doaj +1 more source
Palbociclib with Letrozole in Postmenopausal Women with ER+/HER2- Advanced Breast Cancer: Hematologic Safety Analysis of the Randomized PALOMA-2 Trial. [PDF]
, 2019 BackgroundPALOMA-2 confirmed that first-line palbociclib + letrozole improved progression-free survival (hazard ratio, 0.58; 95% confidence interval, 0.46-0.72) in postmenopausal women with estrogen receptor-positive (ER+)/human epidermal growth factor ...
Diéras, Véronique +11 more
core
Management of Febrile Neutropenia - a German Prospective Hospital Cost Analysis in Lymphoproliferative Disorders, Non-Small Cell Lung Cancer, and Primary Breast Cancer [PDF]
, 2011 Background: Febrile neutropenia/leukopenia (FN/FL) is the most frequent dose-limiting toxicity of myelosuppressive chemotherapy, but German data on economic consequences are limited.
Angela Ihbe-Heffinger +19 more
core +1 more source
Reinforcement learning and Bayesian data assimilation for model-informed precision dosing in oncology [PDF]
arXiv, 2020 Model-informed precision dosing (MIPD) using therapeutic drug/biomarker monitoring offers the opportunity to significantly improve the efficacy and safety of drug therapies. Current strategies comprise model-informed dosing tables or are based on maximum a-posteriori estimates.
arxiv
Microneedle Patch for In Situ Neutrophil Monitoring
Advanced Science, EarlyView.An in situ chromogenic microneedle patch that achieves daily blood neutrophil monitoring without vascular invasion or laboratory apparatus is developed. The detection ability is well demonstrated in a chemotherapy‐induced neutropenic rat model and can be read out using a mobile phone application.
Ziyi Lu +26 more
wiley +1 more source