Results 61 to 70 of about 151,694 (306)

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Neutropenias congénitas Congenital neutropenias

Revista Cubana de Hematología, Inmunología y Hemoterapia, 2004
Los neutrófilos desempeñan un papel vital en la protección del organismo frente a infecciones bacterianas y micóticas. La neutropenia crónica severa, se define como un número absoluto de neutrófilos menor de 500xmm3 que persiste meses o años. Las causas de esta condición son múltiples; pueden ser congénitas y existir desde el nacimiento, o adquiridas y
Aramís Núñez Quintana, Ileana Nordet Carrera, Andrea Menéndez Veitía, Alejandro González Otero   +3 more
openaire   +1 more source

Neutropenia in children: clinical masks and therapeutic approach

Zdorovʹe Rebenka, 2018
Neutropenic syndrome is quite common in pediatric practice. Its nature is diverse, and every case of neutropenia needs thorough differential diagnosis to determine the patient’s management.
S.I. Ilchenko, O.S. Koreniuk, A.A. Fialkovskaya   +2 more
doaj   +1 more source

Cefepime-Induced Neutropenia: A Case Report and Literature Review

, 2023
Somaya Koraysh,1 Junais Koleri,2 Maisa Ali2 1Department of Pharmacy, Hamad Bin Khalifa Medical City, Hamad Medical Corporation, Doha, Qatar; 2Department of Infectious Disease, Communicable Disease Center, Hamad Medical Corporation, Doha ...
Koraysh S, Koleri J, Ali M
core  

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Adjuvant Chemotherapy for Breast Cancer in a Patient with Primary Autoimmune Neutropenia

Breast Cancer: Basic and Clinical Research, 2013
We report an extremely rare and complex case of a 44-year-old woman diagnosed with an early stage triple negative breast cancer in the setting of primary autoimmune neutropenia with a pre-existing severe neutropenia.
Michael Trus, Kavita Dhamanaskar, Jayson Potts, Parveen Wasi, Satvir Bains, Louise Bordeleau   +5 more
doaj   +1 more source

Cost‐effectiveness of DPYD genotyping prior to fluoropyrimidine‐based treatment for colorectal cancer in Wales

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background Regulatory guidance in the United Kingdom advises DPYD genotyping prior to fluoropyrimidine‐based treatment. This economic evaluation estimated the costs and outcomes associated with DPYD screening prior to prescribing fluoropyrimidines for colorectal cancer in Wales and also considers additional variants to those included in ...
Catrin O. Plumpton, Sian M. Morgan, Richard A. Adams, Samantha Cox, Angharad A. Rudkin, Megan Fealey, Craig Barrington, Michelle D. Wood, Dyfrig A. Hughes   +8 more
wiley   +1 more source

Chronic neutropenia in childhood: experience of a tertiary center

Jornal de Pediatria
Objective: To assess the prevalence of chronic neutropenia (CN) and the clinical profile of patients with CN aged up to 18 years, followed in the pediatric hematology, rheumatology, or immunology outpatient clinic of a tertiary medical center from May 1,
Letícia Matushita, Elvis Terci Valera, Davi Casale Aragon, Carlos Alberto Scridelli, Persio Roxo-Junior, Luciana Martins de Carvalho   +5 more
doaj   +1 more source

A multicenter prospective study of 515 febrile neutropenia episodes in Argentina during a 5-year period.

PLoS ONE, 2019
For better management of patients with febrile neutropenia, our study investigated the epidemiologic, microbiologic, and clinical characteristics of adult inpatients with febrile neutropenia and their mortality-associated factors. To this end, we carried
Roberto L Parodi, Mariana Lagrutta, Mauro Tortolo, Estefanía Navall, María S Rodríguez, Gervasio F Sasia, Lucas F De Candia, Matias A Gruvman, Oscar Bottasso, Alcides A Greca   +9 more
doaj   +1 more source

Efficacy and Safety of In-Asia-Manufactured rhG-CSF 300 mcg As Primary Prophylaxis for Prevention of CHOP Chemotherapy-induced Severe Neutropenia in Elderly Patients with Lymphoma Non-Hodgkin

Indonesian Journal of Cancer, 2009
Penelitian open-label, non-komparatif ini dilakukan untuk mengevaluasi efektivitas dan keamanan recombinant human G-CSF produksi Asia sebagai profilaksis primer dalam pencegahan neutropenia derajat berat pada pasien usia lanjut (>60 tahun) dengan limfoma
Harryanto Reksodiputro, Zubairi Djoerban, Karmel L. Tambunan, Aru W. Sudoyo, Abidin Widjanarko, Djumhana Atmakusuma, Syafrizal Syafei, Nugroho Prayogo, Ronald Hukom, Dody Ranuhardy, Zakifman Jack, Asrul Harsal, Noorwati S -, Bambang Karsono, Shufrie Effendi, Hilman Tadjoedin   +15 more
doaj   +1 more source