Results 51 to 60 of about 151,694 (306)

Continuous Intravenous Administration of Granulocyte-Colony-Stimulating Factors—A Breakthrough in the Treatment of Cancer Patients with Febrile Neutropenia

Medicina, 2021
Background: Febrile neutropenia (FN) remains one of the most challenging problems in medical oncology and is a very severe side effect of chemotherapy.
Călin Căinap, Sânziana Cetean-Gheorghe, Laura Ancuta Pop, Daniel Corneliu Leucuta, Doina Piciu, Andra Mester, Cătălin Vlad, Crişan Ovidiu, Alexandra Gherman, Cristina Crişan, Alina Bereanu, Ovidiu Bălăcescu, Anne Marie Constantin, Irina Dicu, Loredana Bălăcescu, Adina Stan, Patriciu Achimaş-Cadariu, Simona Căinap   +17 more
doaj   +1 more source

Pharmacokinetics, Effectiveness and Safety of Certolizumab Pegol in Children and Adolescents With Active Juvenile Idiopathic Arthritis: 9+‐Year Results From a Multicenter, Open‐Label Study

Arthritis &Rheumatology, EarlyView.
Objective The purpose of this study was to assess the pharmacokinetics, effectiveness, safety, and immunogenicity of certolizumab pegol (CZP) in polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods Pediatric Arthritis Study of Certolizumab Pegol (NCT01550003), a multicenter, open‐label study, enrolled patients aged 2 to 17 years with ...
Hermine I. Brunner, Lyudmila Grebenkina, Irina Nikishina, Ekaterina Alexeeva, Vyacheslav Chasnyk, Carlos Abud‐Mendoza, Nadina Rubio‐Pérez, Heinrike Schmeling, María del Rocio Maldonado‐Velázquez, Diane Brown, Andrew Zeft, Esi Morgan, C. Egla Rabinovich, Daniel Kingsbury, Hulya Bukulmez, Beth Gottlieb, Thomas Griffin, Lisa Imundo, Stacey Tarvin, Earl Silverman, Laura Shaughnessy, Saori Shimizu, Paulette Williams, Rocío Lledó‐García, Gauri Utturkar, Baran Ufuktepe, Alberto Martini, Daniel J. Lovell, Nicolino Ruperto, the Paediatric Rheumatology International Trials Organisation (PRINTO); the Pediatric Rheumatology Collaborative Study Group (PRCSG), Hermine I. Brunner, Lyudmila Grebenkina, Irina Nikishina, Ekaterina Alexeeva, Vyacheslav Chasnyk, Carlos Abud‐Mendoza, Nadina Rubio‐Pérez, Heinrike Schmeling, María del Rocio Maldonado‐Velázquez, Diane Brown, Andrew Zeft, Esi Morgan, C. Egla Rabinovich, Daniel Kingsbury, Hulya Bukulmez, Beth Gottlieb, Thomas Griffin, Lisa Imundo, Stacey Tarvin, Earl Silverman, Alberto Martini, Daniel L. Lovell, Nicolino Ruperto   +52 more
wiley   +1 more source

Impact of Neutropenia on Clinical Outcomes in Critically Ill Patients with Acute Respiratory Failure

Pulmonary Therapy
Introduction Neutropenia is a common clinical condition in critically ill patients and may be associated with poor outcomes, particularly in the context of acute respiratory failure (ARF).
Hwan Il Kim, Seong Mi Moon, Hyo Seok Oh, Ryoung-Eun Ko   +3 more
doaj   +1 more source

Neutropenia in Childhood—A Narrative Review and Practical Diagnostic Approach

Hematology Reports
Neutropenia refers to a decrease in the absolute neutrophil count according to age and race norms and poses a common concern in pediatric practice. Neutrophils serve as host defenders and act crucially in acute inflammation procedures.
Georgios Katsaras, Silouani Koutsi, Evdokia Psaroulaki, Dimitra Gouni, Pelagia Tsitsani   +4 more
doaj   +1 more source

Retrospective analysis of cases with low dose methotrexate-induced neutropenia [PDF]

Objective: Low dosemethotrexate (MTX) is among the most commonly used drugs in rheumatology and rarely associated with neutropenia. It is generally observed as a result of improper use or in patients with risk factors for toxicity.
Elif Dinçses Nas, Sevilay Batıbay
core   +1 more source

Efficacy and safety of empagliflozin for treating neutropenia and neutrophil dysfunction in paediatric patients with glycogen storage disease type Ib: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Glycogen storage disease type Ib (GSD‐Ib) is a rare genetic disorder causing neutropenia and neutrophil dysfunction in children. G‐CSF has been the primary treatment, but emerging data support the potential of empagliflozin, an SGLT2 inhibitor, as a promising investigational option.
Elizabeth Iwasyk, Ryan Jin, Fabio Tuzzolino, Giusy Ranucci, Donatella Madonia, Alessio Provenzani   +5 more
wiley   +1 more source

Hubungan Antara Parameter Hematologi saat Perawatan Fase Induksi dengan Kejadian Demam Neutropenia pada Anak Leukemia Limfoblastik Akut

Sari Pediatri, 2016
Latar belakang. Demam neutropenia yang terjadi, terutama fase induksi, merupakan keadaan yang mengancam jiwa serta membutuhkan penanganan yang cepat dan segera. Di RSUP Dr. Sardjito, tingkat mortalitas 11% dari 25% insiden demam neutropenia pada Leukemia
Adhitya Putra Pratama, Sunartini Hapsara, Eddy Supriyadi   +2 more
doaj   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

CAQ Corner: Immune‐mediated complications

, 2022
Liver Transplantation, EarlyView.
Mary Thomson, John R. Lake
wiley   +1 more source

Congenital neutropenia: diagnosis, molecular bases and patient management

Orphanet Journal of Rare Diseases, 2011
The term congenital neutropenia encompasses a family of neutropenic disorders, both permanent and intermittent, severe (
Chantelot Christine, Beaupain Blandine, Mahlaoui Nizar, Fenneteau Odile, Donadieu Jean   +4 more
doaj   +1 more source