Results 131 to 140 of about 416,964 (269)

Intraperitoneal G-CSF Stimulation Achieves Human-like Neutrophil Levels in NSG Mice Without Inducing Systemic Inflammation. [PDF]

Int J Mol Sci
Elrod R, Lu Y, Brochhausen C, Schönmehl R, Herrmann M, Zhang H, Mohr C, Ledermann Y, Blum L, Boettcher M, Klinke-Petrowsky M, Knopf J, Elrod J.   +12 more
europepmc   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Primary human neutrophils and monocytes migrate along endothelial cell boundaries to optimize search efficiency under static in vitro conditions

Biology Open
Nele Honig, Christina Teubert, Lucas Lamparter, Marius N. Keller, Judith Austermann, Philipp Berger, Anne Schmitz, Christiane Rasch, Harald Nüsse, Jürgen Klingauf, Luise Erpenbeck, Johannes Roth, Milos Galic   +12 more
doaj   +1 more source

Injury to the thorax is a dominant contributor to post-traumatic neutrophil mediated inflammatory response. [PDF]

Eur J Trauma Emerg Surg
van Eerten FJC, Duebel LV, de Fraiture EJ, Hanlo MF, Breuking EA, Brands SR, van den Bosch TD, van Wessem KJP, Vrisekoop N, Koenderman L, Hietbrink F.   +10 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Neutrophils Are on a Roll [PDF]

Trends in Immunology, 2019
openaire   +2 more sources

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Mass cytometry reveals complex neutrophil heterogeneity in patients with severe sepsis. [PDF]

Intensive Care Med Exp
Lima PDA, Yu C, Hunt M, Lamontagne F, Adhikari NKJ, Marshall JC, Hindmarch CCT, Maslove DM.   +7 more
europepmc   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Neutrophils and Neutrophil Extracellular Traps in Hepatic Ischemia-Reperfusion Injury: Molecular Mechanisms and Therapeutic Strategies. [PDF]

Int J Mol Sci
Xu F, Wang M, Wang B, Yang J, Qian X.
europepmc   +1 more source