Results 291 to 300 of about 1,017,928 (387)

Lifespan‐Regulated CAR‐Macrophages from Myeloid Progenitors for Enhanced Colorectal Cancer Therapy

Advanced Science, EarlyView.
Using a tamoxifen‐inducible Hoxb8 system, proliferative bone marrow progenitors can be generated, which are subsequently engineered with an anti‐CEA CAR construct containing a suicide gene (iCas9) and differentiated into CAR‐macrophages. This method facilitates scale up the production of CAR‐macrophages.
Chuancheng Gao, Fangling Hong, Yao Dong, Yong Fu, Yunong Ma, Xuedi Sun, Junfeng Zhang, Jiangning Chen, Zhen Huang   +8 more
wiley   +1 more source

Prolonged immune activation in post-acute sequelae of SARS-CoV-2: neutrophil dynamics and therapeutic insights. [PDF]

Exp Mol Med
Yu M, Hwang S, Jang H, Park D, Kim J, Gil J, Choi JH, Jang SG, Choi I, Jung Y, Kwon W, Kim SM, Kim YI, Kim H, Oh T, Lee JS, Song MS, Lee S, Choi YK.   +18 more
europepmc   +1 more source

Regular versus Irregular Exercise Differentially Modulates Hippocampal‐Hepatic Acetylcholine Flux to Coordinate Fear Memory Extinction and Liver Inflammation

Advanced Science, EarlyView.
Ma et al. report the hippocampal and hepatic acetylcholine (ACh) levels are differently modulated by regular versus irregular exercise, which contributes to coordinate hippocampal astrocyte activity and hepatic FBXL6high neutrophil recruitment. This ACh‐modulated brain‐liver circuit links the effects of exercise on fear memory extinction and liver ...
Pengjiao Ma, Kuan Zhang, Long Yi, Chuanyan Yang, Hedong Lang, Jianbin Sun, Jin Li, Qian Bai, Yuhang He, Shuang‐Shuang Dai, Man‐Tian Mi   +10 more
wiley   +1 more source

Mesenchymal stromal cells modulate neutrophil phenotype via paracrine signals. [PDF]

Stem Cell Res Ther
Cherry L, Popescu S, Neculachi CA, Nastase-Rusu EG, Marinescu-Colan CI, Cosman BP, Ciortan L, Martelli F, Simionescu M, Butoi E, Burlacu A, Bogdan Preda M.   +11 more
europepmc   +1 more source

Injectable BMSC‐Based Extracellular Matrix‐Mimicking Microtissue for Myocardial Infarction Repair

Advanced Science, EarlyView.
A novel injectable biomimetic extracellular matrix scaffold (JLSV) is designed for enhanced delivery of bone marrow‐derived mesenchymal stem cells (BMSCs). By utilizing janus basic nanotubes, laminin, stromal‐derived factor‐1 alpha, and vascular endothelial growth factor, this innovative JLSV–BMSC microtissue shows promise in myocardial infarction ...
Lina Yao, Huailong An, Cong Fan, Qingsu Lan, Hongyu Zhong, Yun Zhang, Libo Zhou, Panpan Hao   +7 more
wiley   +1 more source

Natural Flavonoid Nobiletin Attenuates Allergic Asthma via Suppression of STAT3/PI3K-AKT and Neutrophil Extracellular Traps. [PDF]

Food Sci Nutr
He W, Xu Y, Zhu L, Li J, Zhang J, Wu Q.
europepmc   +1 more source

Generation of a Neutrophil Chemotactic Agent by Spermatozoa: Role of Complement and Regulation by Seminal Plasma Factors

, 1976
Robert A. Clark, Seymour J. Klebanoff
openalex   +1 more source

Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps

Science Translational Medicine, 2016
Juwon Park, R. Wysocki, Zohreh Amoozgar, L. Maiorino, M. Fein, J. Jorns, A. Schott, Yumi Kinugasa-Katayama, Youngseok Lee, N. Won, E. Nakasone, Stephen A. Hearn, Victoria Küttner, J. Qiu, A. S. Almeida, N. Perurena, K. Kessenbrock, Michael S. Goldberg, M. Egeblad   +18 more
semanticscholar   +1 more source

Sleep Deprivation Aggravates Periodontitis Through Trigeminal‐Periodontal Neuroimmune Pathway Mediated by the AChE‐ACh‐α7nAChR Axis

Advanced Science, EarlyView.
Sleep deprivation (SD) exacerbates ligature‐induced periodontitis (LIP) through the trigeminal nerve‐periodontal neuroimmune pathway mediated by the acetylcholinesterase (AChE)‐acetylcholine (ACh)‐α7 nicotinic receptor (α7nAChR) axis. While electroacupuncture (EA) alleviates the condition of LIP combined with SD by activating the α7nAChR.
Kehao Liu, Qi Huang, Mingcong Yang, Ziyu Huang, Kamoran Tuerhong, Yue Zu, Ying Xie, Xuehui Hu, Qianyu Zhang, Ping He, Nannan Huang, Rong Zhang, Yuzhou Li, Sheng Yang   +13 more
wiley   +1 more source

The role of neutrophils in vasospasm and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage: Is it time for a SAH clinical trial targeting neutrophils? [PDF]

J Cereb Blood Flow Metab
Wroe WW, Zeineddine HA, Blackburn SL, Aronowski J, McBride DW.   +4 more
europepmc   +1 more source