Results 91 to 100 of about 36,600 (202)

DEK-targeting DNA aptamers as therapeutics for inflammatory arthritis

Nature Communications, 2017
DEK is a secreted protein abundant in the synovia of patients with juvenile idiopathic arthritis. Here the authors show DEK is important for neutrophil extracellular trap formation and joint inflammation, and demonstrate therapeutic efficacy of DEK ...
Nirit Mor-Vaknin, Anjan Saha, Maureen Legendre, Carmelo Carmona-Rivera, M Asif Amin, Bradley J. Rabquer, Marta J. Gonzales-Hernandez, Julie Jorns, Smriti Mohan, Srilakshmi Yalavarthi, Dave A. Pai, Kristine Angevine, Shelley J. Almburg, Jason S. Knight, Barbara S. Adams, Alisa E. Koch, David A. Fox, David R. Engelke, Mariana J. Kaplan, David M. Markovitz   +19 more
doaj   +1 more source

The selective estrogen receptor modulator raloxifene inhibits neutrophil extracellular trap formation.

Frontiers in Immunology, 2016
Raloxifene is a selective estrogen receptor modulator typically prescribed for the prevention/treatment of osteoporosis in postmenopausal women. Although raloxifene is known to have anti-inflammatory properties, its effect on human neutrophils, the ...
Roxana Flores, Simon Döhrmann, Christina Schaal, Abdul Hakkim, Victor Nizet, Victor Nizet, Victor Nizet, Ross Corriden   +7 more
doaj   +1 more source

What makes gouty inflammation so variable? [PDF]

, 2017
Acute gout arthritis flares contribute dominantly to gout-specific impaired health-related quality of life, representing a progressively increasing public health problem.
Terkeltaub, Robert
core   +2 more sources

Identification of potential biological processes and key genes in diabetes-related stroke through weighted gene co-expression network analysis

BMC Medical Genomics
Background Type 2 diabetes mellitus (T2DM) is an established risk factor for acute ischemic stroke (AIS). Although there are reports on the correlation of diabetes and stroke, data on its pathogenesis is limited.
Yong He, Yang Bai, Qin Huang, Jian Xia, Jie Feng   +4 more
doaj   +1 more source

Platelet-Activating Factor-Induced Reduction in Contact Hypersensitivity Responses Is Mediated by Mast Cells via Cyclooxygenase-2-Dependent Mechanisms [PDF]

, 2018
Platelet-activating factor (PAF) stimulates numerous cell types via activation of the G protein-coupled PAF receptor (PAFR). PAFR activation not only induces acute proinflammatory responses, but it also induces delayed systemic immunosuppressive effects ...
FitzGerald, Garret A., Kaplan, Mark H., Ocana, Jesus A., Pawelzik, Sven-Christian, Romer, Eric, Sahu, Ravi, Travers, Jeffrey B.   +6 more
core   +1 more source

Platelets as mediators of Thromboinflammation in chronic Myeloproliferative Neoplasms [PDF]

, 2019
Chronic myeloproliferative neoplasms (MPN) are stem cell disorders driven by mutations in JAK2, CALR, or MPL genes and characterized by myeloid proliferation and increased blood cell counts.
Heller, Paula Graciela, Marin Oyarzún, Cecilia Paola   +1 more
core   +1 more source

Effect of Adhesion and Substrate Elasticity on Neutrophil Extracellular Trap Formation

Frontiers in Immunology, 2019
Neutrophils are the most abundant type of white blood cells. Upon stimulation, they are able to decondense and release their chromatin as neutrophil extracellular traps (NETs). This process (NETosis) is part of immune defense mechanisms but also plays an
Luise Erpenbeck, Antonia Luise Gruhn, Galina Kudryasheva, Gökhan Günay, Gökhan Günay, Daniel Meyer, Julia Busse, Elsa Neubert, Elsa Neubert, Michael P. Schön, Michael P. Schön, Florian Rehfeldt, Sebastian Kruss   +12 more
doaj   +1 more source

Peptidylarginine deiminases as drug targets in neonatal hypoxic-ischemic encephalopathy [PDF]

, 2016
Oxygen deprivation and infection are major causes of perinatal brain injury leading to cerebral palsy and other neurological disabilities. The identification of novel key factors mediating white and grey matter damage are crucial to allow better ...
Adhami, Alonso-Alconada, Azad, Baburamani, Balandraud, Balduini, Block, Bozdag, Brinkmann, Brown, Byrd, Chavanas, Chavanas, Cherian, Cherrington, Choi, Christophorou, Cotten, Cui, Culman, David, Dingley, Dixon, Douglas-Escobar, Dragunow, Dwivedi, Erny, Fan, Faulkner, Ferretti, Ferriero, Fox, Fricker, Garcia-Romo, Ginet, Goyal, Guerrin, Gupta, Gupta, György, Hagberg, Hagberg, Hagiwara, Horibata, Imm, Ireland, Ireland, Karlsson, Kearney, Keilhoff, Kendall, Kendall, Kessenbrock, Keunen, Kholia, Knuckley, Kopatz, Kumral, Kurinczuk, Lande, Lange, Lange, Latuga, Law, Lee, Li, Li, Li, Loos, Loos, Luo, Ma, Mallard, Mallard, Marcos, Mari, Martin, Mastronardi, McCormack, Mirza, Moelants, Moelants, Musse, Neeli, Neeli, Neher, Neher, Neniskyte, Neumann, Northington, Perlman, Pirianov, Prempunpong, Proost, Robertson, Robertson, Rocha-Ferreira, Romano-Keeler, Romero, Sharda, Sherman, Simak, Slack, Spengler, Stenberg, Stys, Subramanian, Trabocchi, U, Uria-Avellanal, Villanueva, Vossenaar, Wang, Wang, Wassink, Wei, Witalison, Wood, Wright, Wu, Wu, Wyatt, Wyatt, Yektaei-Karin, Yi, Yost, Zhu, Zhu, Zhu, Zhu, Zipfel   +130 more
core   +2 more sources

Monosodium urate crystals induce extracellular DNA traps in neutrophils, eosinophils and basophils but not in mononuclear cells

Frontiers in Immunology, 2012
Neutrophil extracellular traps (NETs) are fibers of extracellular DNA released from neutrophils due to overwhelming phagocytic stimuli. The function of NETs is to trap and kill microbes to avoid spreading of potential pathogens.
Christine eSchorn, Christina eJanko, Melanie eLatzko, Ricardo eChaurio, Georg eSchett, Martin eHerrmann   +5 more
doaj   +1 more source

A Precision Medicine Approach Uncovers a Unique Signature of Neutrophils in Patients With Brushite Kidney Stones

Kidney International Reports, 2020
Introduction: We have previously found that papillary histopathology differs greatly between calcium oxalate and brushite stone formers (SF); the latter have much more papillary mineral deposition, tubular cell injury, and tissue fibrosis.
Mohammad Shahidul Makki, Seth Winfree, James E. Lingeman, Frank A. Witzmann, Elaine M. Worcester, Amy E. Krambeck, Fredric L. Coe, Andrew P. Evan, Sharon Bledsoe, Kristin J. Bergsland, Suraj Khochare, Daria Barwinska, James C. Williams, Jr., Tarek M. El-Achkar   +13 more
doaj   +1 more source