Results 101 to 110 of about 36,600 (202)

Hypoxia increases neutrophil-driven matrix destruction after exposure to Mycobacterium tuberculosis. [PDF]

, 2018
The importance of neutrophils in the pathology of tuberculosis (TB) has been recently established. We demonstrated that TB lesions in man are hypoxic, but how neutrophils in hypoxia influence lung tissue damage is unknown.
A Dorhoi, A Mantovani, AM Houghton, AM McInturff, C Peyssonnaux, CW Ong, CW Ong, D Nickel, J Rius, JE Galagan, JM McCracken, K Dheda, K Ostridge, K Steinwede, LW Garratt, M Datta, MP Berry, N Borregaard, N Branzk, NN McGovern, PM Elks, PM Elks, PT Elkington, PT Elkington, PT Elkington, PT Elkington, S Aliberti, SC Cheng, SH Kaufmann, SH Oehlers, SR Walmsley, SS Shell, ST Reece, SY Eum, TA Fuchs, V Nizet, V Ramos-Kichik   +36 more
core   +1 more source

Skin and Systemic Inflammation in Schnitzler's Syndrome Are Associated With Neutrophil Extracellular Trap Formation [PDF]

, 2019
Schnitzler's syndrome is a rare autoinflammatory disorder characterized by interleukin-1ß-mediated and neutrophil-dominated inflammation. Neutrophil extracellular traps (NETs) are web-like structures of decondensed chromatin, histones, and antimicrobial ...
Bonnekoh, Hanna, Hoffmann, Sheila, Krause, Karoline, Maurer, Marcus, Scheffel, Jörg, Wu, Jim   +5 more
core   +3 more sources

The type I interferon signature in leukocyte subsets from peripheral blood of patients with early arthritis: a major contribution by granulocytes [PDF]

, 2016
The type I interferon (IFN) signature in rheumatoid arthritis (RA) has shown clinical relevance in relation to disease onset and therapeutic response. Identification of the cell type(s) contributing to this IFN signature could provide insight into the ...
Conny J. van der Laken, Cornelis L. Verweij, Dirkjan van Schaardenburg, Elise Mantel, Hetty J. Bontkes, Johannes W. Bijlsma, Joyce Lübbers, Samina Turk, Saskia Vosslamber, Tamarah D. de Jong   +9 more
core   +2 more sources

Mapping genetic determinants of host susceptibility to Pseudomonas aeruginosa lung infection in mice. [PDF]

, 2016
Background: P. aeruginosa is one of the top three causes of opportunistic human bacterial infections. The remarkable variability in the clinical outcomes of this infection is thought to be associated with genetic predisposition.
A Bragonzi, A Bragonzi, A Bragonzi, A Corken, A Darvasi, Alessandra Bragonzi, C Cigana, C Morissette, C Morissette, CC Elbers, Cristina Cigana, CS Haley, D Nguyen, DL Demeo, DM Menge, E Amiel, EE Smith, F Iraqi, F Iraqi, FA Iraqi, FA Iraqi, Fuad A. Iraqi, GA Churchill, GR Cutting, GS Cooke, H Shinohara, I Bianconi, Ida De Fino, J Dupuis, JB Lyczak, JE Pennington, JM Collaco, K Sapru, K Tremblay, Karl W. Broman, KW Broman, L Guillot, LD Hazlett, Lorenza Spagnuolo, M Hernandez-Valladares, M Munoz, M Simone De, M Tam, M Verdrengh, MA Jong de, Maura De Simone, ML Drumm, N Lorè, NI Lore, Nicola Ivan Lorè, R Mashima, R Mashima, R Williams, S Aerts, S Gruenheid, S Worgall, SL Cheng, SL Gellatly, SM Vidal, TT Wu, V DeRose, Y Moreau, Y Zhan   +62 more
core   +1 more source

Effects of Aggregatibacter actinomycetemcomitans leukotoxin on neutrophil migration and extracellular trap formation

Journal of Oral Microbiology, 2016
Background: Aggressive periodontitis is associated with the presence of Aggregatibacter actinomycetemcomitans, a leukotoxin (Ltx)-producing periodontal pathogen. Ltx has the ability to lyse white blood cells including neutrophils.
Josefine Hirschfeld, Helen M. Roberts, Iain L. C. Chapple, Marijo Parčina, Søren Jepsen, Anders Johansson, Rolf Claesson   +6 more
doaj   +1 more source

Brain-Death in Rats Increases Neutrophil Extracellular Trap Formation in Donor Organs

Transplant International
During brain-death, increased numbers of neutrophils are recruited to organs as part of the inflammatory response. In the organ microenvironment, the recruited neutrophils may release neutrophil extracellular traps (NETs) through interaction with various
Maryna Van Zyl, Maryna Van Zyl, Roberto Armstrong Junior, Petra Ottens, Harry Van Goor, Mia-Jeanne Van Rooy, Ton Lisman, Henri G. D. Leuvenink, Jan-Luuk Hillebrands   +8 more
doaj   +1 more source

Clinical Implications of Excessive Neutrophil Extracellular Trap Formation in Renal Autoimmune Diseases

Kidney International Reports, 2019
Neutrophil extracellular traps (NETs) are extracellular DNA structures covered with antimicrobial peptides, danger molecules, and autoantigens that can be released by neutrophils.
Laura S. van Dam, Ton J. Rabelink, Cees van Kooten, Y.K. Onno Teng   +3 more
doaj   +1 more source

Innate immunity turned inside-out: antimicrobial defense by phagocyte extracellular traps [PDF]

, 2009
The formation of extracellular traps (ETs) by phagocytic cells has been recognized as a novel and important mechanism of the host innate immune response against infections.
Maren von Köckritz-Blickwede, Victor Nizet   +1 more
core   +2 more sources

Nanosilver induces the formation of neutrophil extracellular traps in mouse neutrophil granulocytes

Ecotoxicology and Environmental Safety, 2019
As a new type of antibacterial agent, nanosilver has attracted great attention in biomedical applications. However, the safety of nanosilver to humans and the environment has not been well elucidated. The objective of this study was to investigate the influence of nanosilver on novel effector mechanism of neutrophil extracellular traps (NETs), and its ...
Chaoqun, Wang, Xiao, Liu, Zhen, Han, Xu, Zhang, Jingjing, Wang, Kai, Wang, Zhengtao, Yang, Zhengkai, Wei   +7 more
openaire   +2 more sources

Rol de las plaquetas en la inflamación [PDF]

, 2014
En condiciones fisiológicas, la activación de las plaquetas circulantes es limitada de manera constitutiva a través de la liberación, a partir del endotelio vascular, de potentes inhibidores de la función plaquetaria tales como el óxido nítrico y ...
Etulain, Julia, Schattner, Mirta Ana
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