Results 11 to 20 of about 19,957 (258)
Neutrophil Extracellular Trap Formation: Physiology, Pathology, and Pharmacology [PDF]
Biomolecules, 2019 Neutrophil extracellular traps (NETs), a unique DNA framework decorated with antimicrobial peptides, have been in the scientific limelight for their role in a variety of pathologies ranging from cystic fibrosis to cancer.
Mithunan Ravindran +2 more
doaj +4 more sources
Recombinant Thrombomodulin Suppresses Histone-Induced Neutrophil Extracellular Trap Formation [PDF]
Frontiers in Immunology, 2019 Histones, the major protein components of chromatin, are released into the extracellular space during sepsis, trauma, and ischemia-reperfusion injury, and subsequently mediate organ failure.
Binita Shrestha +8 more
doaj +3 more sources
Diabetes Primes Neutrophils for Neutrophil Extracellular Trap Formation through Trained Immunity
ResearchNeutrophils are primed for neutrophil extracellular trap (NET) formation during diabetes, and excessive NET formation from primed neutrophils compromises wound healing in patients with diabetes.
Sanjeeb Shrestha +14 more
doaj +3 more sources
Triptolide inhibits neutrophil extracellular trap formation [PDF]
Annals of Translational Medicine, 2021 Triptolide (PG490), as a triterpene dicyclic oxide has been reported to increase the generation of reactive oxygen species (ROS) and nitric oxide (NO) and induce apoptosis of RAW 264.7 cells in a dose-dependent manner. The activity of death NETs plays an important role in anti-bacterial processes in the human body.
Guan, Haiyu +5 more
openaire +2 more sources
Pneumolysin activates neutrophil extracellular trap formation [PDF]
Clinical and Experimental Immunology, 2016 Summary The primary objective of the current study was to investigate the potential of the pneumococcal toxin, pneumolysin (Ply), to activate neutrophil extracellular trap (NET) formation in vitro. Isolated human blood neutrophils were exposed to recombinant Ply (5-20 ng ml−1) for 30–90 min at 37°C and NET formation measured using the ...
Nel, Jan Gert +7 more
openaire +3 more sources
Neutrophil Extracellular Traps Initiate Gallstone Formation [PDF]
Immunity, 2019 The presence of gallstones (cholelithiasis) is a highly prevalent and severe disease and one of the leading causes of hospital admissions worldwide. Due to its substantial health impact, we investigated the biological mechanisms that lead to the formation and growth of gallstones.
Luis E. Muñoz +24 more
openaire +3 more sources
Metabolic requirements for neutrophil extracellular traps formation [PDF]
Immunology, 2015 SummaryAs part of the innate immune response, neutrophils are at the forefront of defence against infection, resolution of inflammation and wound healing. They are the most abundant leucocytes in the peripheral blood, have a short lifespan and an estimated turnover of 1010 to 1011 cells per day.
Oscar, Rodríguez-Espinosa +4 more
openaire +2 more sources
H2 Inhibits the Formation of Neutrophil Extracellular Traps
JACC: Basic to Translational Science, 2022 Neutrophil extracellular traps (NETs) contribute to inflammatory pathogenesis in numerous conditions, including infectious and cardiovascular diseases, and have attracted attention as potential therapeutic targets. H2 acts as an antioxidant and has been clinically and experimentally proven to ameliorate inflammation.
Shirakawa, Kohsuke +7 more
openaire +2 more sources
Live Imaging and Quantification of Neutrophil Extracellular Trap Formation [PDF]
Current Protocols, 2021 AbstractNeutrophilExtracellular Trap (NET) formation (NETosis) is a unique process that occurs in response to numerous stimuli. To investigate NETosis, we created a method that can be used easily without the need for complex programming abilities and commercial software packages.
Silva, Lakmali Munasinghage +3 more
openaire +2 more sources
MicroRNAs as New Regulators of Neutrophil Extracellular Trap Formation [PDF]
International Journal of Molecular Sciences, 2021 Neutrophil extracellular traps (NETs) are formed after neutrophils expelled their chromatin content in order to primarily capture and eliminate pathogens. However, given their characteristics due in part to DNA and different granular proteins, NETs may induce a procoagulant response linking inflammation and thrombosis.
Sonia Águila +8 more
openaire +2 more sources