Cells, 2021 Depression is an independent risk factor for cardiovascular disease (CVD). We have previously shown that repeated social defeat (RSD) exaggerates atherosclerosis development by enhancing neutrophil extracellular trap (NET) formation.
Takeshi Sugimoto +11 more
doaj +1 more source
Extracellular Acidification Inhibits the ROS-Dependent Formation of Neutrophil Extracellular Traps [PDF]
Frontiers in Immunology, 2017 The inflammatory microenvironment is commonly characterized by extracellular acidosis (pH
Behnen, Martina +4 more
openaire +2 more sources
Pyocyanin-enhanced neutrophil extracellular trap formation requires the NADPH oxidase.
PLoS ONE, 2013 Beyond intracellular killing, a novel neutrophil-based antimicrobial mechanism has been recently discovered: entrapment and killing by neutrophil extracellular traps (NETs).
Balázs Rada +8 more
doaj +1 more source
Platelet-derived exosomes promote neutrophil extracellular trap formation during septic shock
Critical Care, 2020 Background Platelets have been demonstrated to be potent activators of neutrophil extracellular trap (NET) formation during sepsis. However, the mediators and molecular pathways involved in human platelet-mediated NET generation remain poorly defined ...
Yang Jiao +8 more
doaj +1 more source
Autophagy Primes Neutrophils for Neutrophil Extracellular Trap Formation during Sepsis
American Journal of Respiratory and Critical Care Medicine, 2017 Neutrophils are key effectors in the host's immune response to sepsis. Excessive stimulation or dysregulated neutrophil functions are believed to be responsible for sepsis pathogenesis. However, the mechanisms regulating functional plasticity of neutrophils during sepsis have not been fully determined.We investigated the role of autophagy in neutrophil
So Young Park +18 more
openaire +3 more sources
Formation of neutrophil extracellular traps requires actin cytoskeleton rearrangements
Blood, 2022 AbstractNeutrophils are important effector cells in the host defense against invading microorganisms. One of the mechanisms they use to eliminate pathogens is the release of neutrophil extracellular traps (NETs). Although NET release and subsequent cell death known as NETosis have been intensively studied, the cellular components and factors ...
Evelien G. G. Sprenkeler +4 more
openaire +4 more sources
Celastrol Inhibits Inflammatory Stimuli-Induced Neutrophil Extracellular Trap Formation [PDF]
Current Molecular Medicine, 2015 Neutrophil extracellular traps (NETs) are web-like structures released by activated neutrophils. Recent studies suggest that NETs play an active role in driving autoimmunity and tissue injury in diseases including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).
Yu, Y. +10 more
openaire +2 more sources
Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production
Nature Communications, 2018 Optic atrophy 1 (OPA1) is known to be important for mitochondrial fusion and structural integrity. Here, using OPA1 knockout mice, the authors show a detrimental effect on host defense capabilities against pathogen infections.
Poorya Amini +12 more
doaj +1 more source
Neutrophil and Eosinophil DNA Extracellular Trap Formation: Lessons From Pathogenic Fungi
Frontiers in Microbiology, 2021 Fungal infections represent a worldwide health problem. Fungal pathogens are responsible for a variety of conditions, including superficial diseases, allergic pathologies and potentially lethal invasive infections.
Juliana da Costa Silva +5 more
doaj +1 more source
Nucleosomes and neutrophil activation in sickle cell disease painful crisis
Haematologica, 2013 Activated polymorphonuclear neutrophils play an important role in the pathogenesis of vaso-occlusive painful sickle cell crisis. Upon activation, polymorphonuclear neutrophils can form neutrophil extracellular traps.
Marein Schimmel +8 more
doaj +1 more source