Cells, 2021 Depression is an independent risk factor for cardiovascular disease (CVD). We have previously shown that repeated social defeat (RSD) exaggerates atherosclerosis development by enhancing neutrophil extracellular trap (NET) formation.
Takeshi Sugimoto +11 more
doaj +1 more source
Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis. [PDF]
, 2010 DNAX adaptor protein 12 (DAP12) is a trans-membrane adaptor molecule that transduces activating signals in NK and myeloid cells. Absence of functional Dap12 results in osteoclast defects and bone abnormalities.
Adamopoulos, Iannis E +11 more
core +3 more sources
2-Chlorofatty acids: lipid mediators of neutrophil extracellular trap formation
Journal of Lipid Research, 2018 Neutrophils form neutrophil extracellular traps (NETs), which have been implicated in microcirculatory plugging. NET formation (NETosis) involves the fusion of granule and nuclear contents, which are then released in the extracellular space ...
ElisaN.D. Palladino +3 more
doaj +1 more source
Extracellular Acidification Inhibits the ROS-Dependent Formation of Neutrophil Extracellular Traps [PDF]
Frontiers in Immunology, 2017 The inflammatory microenvironment is commonly characterized by extracellular acidosis (pH
Behnen, Martina +4 more
openaire +2 more sources
Activation of conventional protein kinase C (PKC) is critical in the generation of human neutrophil extracellular traps [PDF]
, 2013 BACKGROUND: Activation of NADPH oxidase is required for neutrophil extracellular trap (NET) formation. Protein kinase C (PKC) is an upstream mediator of NADPH oxidase activation and thus likely to have a role in NET formation.
Davidson, Donald J +7 more
core +1 more source
The interrelationship between phagocytosis, autophagy and formation of neutrophil extracellular traps following infection of human neutrophils by Streptococcus pneumoniae [PDF]
, 2017 Neutrophils play an important role in the innate immune response to infection with Streptococcus pneumoniae, the pneumococcus. Pneumococci are phagocytosed by neutrophils and undergo killing after ingestion.
Evans, Tom J. +2 more
core +1 more source
Platelet-derived exosomes promote neutrophil extracellular trap formation during septic shock
Critical Care, 2020 Background Platelets have been demonstrated to be potent activators of neutrophil extracellular trap (NET) formation during sepsis. However, the mediators and molecular pathways involved in human platelet-mediated NET generation remain poorly defined ...
Yang Jiao +8 more
doaj +1 more source
Capability of Neutrophils to Form NETs Is Not Directly Influenced by a CMA-Targeting Peptide [PDF]
, 2006 During inflammatory reaction, neutrophils exhibit numerous cellular and immunological functions, notably the formation of neutrophil extracellular traps (NETs) and autophagy.
Christian Maueröder +8 more
core +3 more sources
Autophagy Primes Neutrophils for Neutrophil Extracellular Trap Formation during Sepsis
American Journal of Respiratory and Critical Care Medicine, 2017 Neutrophils are key effectors in the host's immune response to sepsis. Excessive stimulation or dysregulated neutrophil functions are believed to be responsible for sepsis pathogenesis. However, the mechanisms regulating functional plasticity of neutrophils during sepsis have not been fully determined.We investigated the role of autophagy in neutrophil
So Young Park +18 more
openaire +3 more sources
Role of galectin-3 in bone cell differentiation, bone pathophysiology and vascular osteogenesis [PDF]
, 2017 Galectin-3 is expressed in various tissues, including the bone, where it is considered a marker of chondrogenic and osteogenic cell lineages. Galectin-3 protein was found to be increased in the differentiated chondrocytes of the metaphyseal plate ...
Fantauzzi, Claudia Blasetti +3 more
core +2 more sources