Results 41 to 50 of about 19,957 (258)

P-selectin promotes neutrophil extracellular trap formation in mice [PDF]

Blood, 2015
Key Points NET formation is stimulated by platelet or soluble P-selectin.
Etulain, Julia, Martinod, Kimberly, Wong, Siu Ling, Cifuni, Stephen M., Schattner, Mirta Ana, Wagner, Denisa D.   +5 more
openaire   +3 more sources

Neutrophil extracellular traps mediate neuro-immunothrombosis

Neural Regeneration Research
Neutrophil extracellular traps are primarily composed of DNA and histones and are released by neutrophils to promote inflammation and thrombosis when stimulated by various inflammatory reactions.
Jianbo Lou, Jianning Zhang, Quanjun Deng, Xin Chen   +3 more
doaj   +1 more source

Uremic serum damages endothelium by provoking excessive neutrophil extracellular trap formation

Scientific Reports, 2021
Cardiovascular disease (CVD) is the leading cause of death in patients with chronic kidney disease (CKD). Endothelial cell (EC) dysfunction is a key CKD-specific risk factor; however, the mechanisms by which uremia harms the endothelium are still unclear.
Hoi Woul Lee, Victor Nizet, Jung Nam An, Hyung Seok Lee, Young Rim Song, Sung Gyun Kim, Jwa-Kyung Kim   +6 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Neutrophil extracellular trap formation and nuclease activity in septic patients

BMC Anesthesiology, 2020
Background There is little knowledge, whether in patients with sepsis neutrophil extracellular trap (NET) formation and NET degrading nuclease activity are altered.
Linda E. Cox, Kai Walstein, Lena Völlger, Friederike Reuner, Alexandra Bick, Annika Dötsch, Andrea Engler, Jürgen Peters, Maren von Köckritz-Blickwede, Simon T. Schäfer   +9 more
doaj   +1 more source

Changes in Immune‐Inflammation Status and Acute Ischemic Stroke Prognosis in Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Inflammation is a critical risk factor for poor outcomes in cerebral infarction. Prior studies focused primarily on baseline inflammation status, neglecting dynamic longitudinal changes. We try to investigate the association between immune‐inflammation status alterations and stroke prognosis, and evaluated three systemic biomarkers'
Songfang Chen, Wenting Huang, Yitian Liu, Xuan Chen, Buyu Ke, Qian Shen, Hanyu Cai, Jing Sun, Yan Li, Yungang Cao, Beilei Hu, Keyang Chen   +11 more
wiley   +1 more source

Neutrophil Extracellular Trap Formation Is Independent of De Novo Gene Expression. [PDF]

PLoS ONE, 2016
Neutrophils are essential innate immune cells whose responses are crucial in the clearance of invading pathogens. Neutrophils can respond to infection by releasing neutrophil extracellular traps (NETs).
Gabriel Sollberger, Borko Amulic, Arturo Zychlinsky   +2 more
doaj   +1 more source

Besnoitia besnoiti-induced neutrophil clustering and neutrophil extracellular trap formation depend on P2X1 purinergic receptor signaling

Frontiers in Immunology, 2023
Bovine besnoitiosis is a re-emerging cattle disease caused by the cyst-forming apicomplexan parasite Besnoitia besnoiti. Neutrophil extracellular trap (NET) formation represents an efficient innate immune mechanism of polymorphonuclear neutrophils (PMN ...
Gabriel Espinosa, Iván Conejeros, Lisbeth Rojas-Barón, Carlos Rodrigo Hermosilla, Anja Taubert   +4 more
doaj   +1 more source

Aging‐related Atg5 defect impairs neutrophil extracellular traps formation [PDF]

Immunology, 2017
SummaryFormation of neutrophil extracellular traps (NETs) is an important function of the innate immune system against infections. It has been proven that aging dysregulates immunity and impairs neutrophil function. However, the influence of aging on the ability to produce NETs has yet to be fully addressed. In this study, we tested the hypothesis that
Fengying Xu, Chengmi Zhang, Zui Zou, Erica K. Y. Fan, Linsong Chen, Yuehua Li, Timothy R. Billiar, Mark A. Wilson, Xueyin Shi, Jie Fan   +9 more
openaire   +2 more sources

Host‐Directed Biomaterials for Combatting Bloodstream Infections: From Macrocyclic Peptides to Immune‐Activating Cell Backpacks

Advanced Functional Materials, EarlyView.
Bloodstream infections (BSI) are one of the leading causes of mortality and morbidity in both civilian and military populations. This paper summarizes recent progress in novel treatment strategies to manage BSI arising from both bacterial and fungal pathogens using molecules, particles, and materials to elicit host‐directed immunity.
Thomas Thomou, Jagadish Krishnappa, Justin B. Schaal, Prasad Tongaonkar, Dat Q. Tran, Wenchao Gu, Yung‐Fu Chang, Michael E. Selsted, Shaoyi Jiang, Samir Mitragotri, Michael Super, Christopher J. Bettinger   +11 more
wiley   +1 more source