Results 51 to 60 of about 36,600 (202)

Formation of neutrophil extracellular traps requires actin cytoskeleton rearrangements

Blood, 2022
AbstractNeutrophils are important effector cells in the host defense against invading microorganisms. One of the mechanisms they use to eliminate pathogens is the release of neutrophil extracellular traps (NETs). Although NET release and subsequent cell death known as NETosis have been intensively studied, the cellular components and factors ...
Evelien G. G. Sprenkeler, Anton T. J. Tool, Stefanie S. V. Henriet, Robin van Bruggen, Taco W. Kuijpers   +4 more
openaire   +4 more sources

Neutrophil and Eosinophil DNA Extracellular Trap Formation: Lessons From Pathogenic Fungi

Frontiers in Microbiology, 2021
Fungal infections represent a worldwide health problem. Fungal pathogens are responsible for a variety of conditions, including superficial diseases, allergic pathologies and potentially lethal invasive infections.
Juliana da Costa Silva, Glaucia de Azevedo Thompson-Souza, Marina Valente Barroso, Marina Valente Barroso, Josiane Sabbadini Neves, Rodrigo Tinoco Figueiredo   +5 more
doaj   +1 more source

Neutrophil extracellular traps are associated with disease severity and microbiota diversity in patients with chronic obstructive pulmonary disease [PDF]

, 2017
BACKGROUND: Neutrophil extracellular traps (NETs) have been observed in the airway in COPD, but their clinical and pathophysiological implications have not been defined.OBJECTIVE: To determine if NETs are associated with disease severity in COPD, and how
Agusti, Alison J. Dicker, Andrew J. Cassidy, Bafadhel, Branzk, Brinkmann, Calverley, Caporaso, Caudrillier, Celli, Christopher J. Fong, Colin N.A. Palmer, Dickson, Donnelly, Dworski, Eleanor G. Pumphrey, Elizabeth Furrie, Farnworth, Flynn, Gill Brady, Gisli G. Einarsson, Grabcanovic-Musija, Gray, Greenwood, Guillermo Suarez-Cuartin, Haslett, Hoenderdos, J. Stuart Elborn, James D. Chalmers, Jiang, Juneau, Kessenbrock, Khandpur, Knight, Lange, Leidy, Lozano, Megan L. Crichton, Menegazzi, Metzler, Morris, Obermayer, Oriol Sibila, Papayannopoulos, Pascoe, Pavord, Pedersen, Richens, Sara E. Marshall, Savill, Sayah, Short, Speizer, Stuart Schembri, Vestbo, Wasyla Ibrahim, Willemse, Yipp, Zabieglo   +58 more
core   +2 more sources

Celastrol Inhibits Inflammatory Stimuli-Induced Neutrophil Extracellular Trap Formation [PDF]

Current Molecular Medicine, 2015
Neutrophil extracellular traps (NETs) are web-like structures released by activated neutrophils. Recent studies suggest that NETs play an active role in driving autoimmunity and tissue injury in diseases including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).
Yu, Y., Koehn, C.D., Yue, Y., Li, S., Thiele, G.M., Hearth-Holmes, M.P., Mikuls, T.R., O’Dell, J.R., Klassen, L.W., Zhang, Z., Su, K.   +10 more
openaire   +2 more sources

Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production

Nature Communications, 2018
Optic atrophy 1 (OPA1) is known to be important for mitochondrial fusion and structural integrity. Here, using OPA1 knockout mice, the authors show a detrimental effect on host defense capabilities against pathogen infections.
Poorya Amini, Darko Stojkov, Andrea Felser, Christopher B. Jackson, Carolina Courage, André Schaller, Laurent Gelman, Maria Eugenia Soriano, Jean-Marc Nuoffer, Luca Scorrano, Charaf Benarafa, Shida Yousefi, Hans-Uwe Simon   +12 more
doaj   +1 more source

Mechanical Stability and Fibrinolytic Resistance of Clots Containing Fibrin, DNA, and Histones [PDF]

, 2013
Neutrophil extracellular traps are networks of DNA and associated proteins produced by nucleosome release from activated neutrophils in response to infection stimuli and have recently been identified as key mediators between innate immunity, inflammation,
Ammollo, Aziz, Borissoff, Brill, Brinkmann, Clark, Esmon, Esmon, Fuchs, Fuchs, Gladysheva, Gleber, Guthold, Komissarov, Komorowicz, Longstaff, Longstaff, Massberg, Nikolova, Rocha, Ruf, Ryan, Rábai, Rácz, Saha, Sands, Scrutton, Semeraro, Silva, Smeeth, Walker, Weisel, Weisel, Wohner, Xu, Yang, Yeromonahos   +36 more
core   +1 more source

Nucleosomes and neutrophil activation in sickle cell disease painful crisis

Haematologica, 2013
Activated polymorphonuclear neutrophils play an important role in the pathogenesis of vaso-occlusive painful sickle cell crisis. Upon activation, polymorphonuclear neutrophils can form neutrophil extracellular traps.
Marein Schimmel, Erfan Nur, Bart J. Biemond, Gerard J. van Mierlo, Shabnam Solati, Dees P. Brandjes, Hans-Martin Otten, John-John Schnog, Sacha Zeerleder   +8 more
doaj   +1 more source

Uremic serum damages endothelium by provoking excessive neutrophil extracellular trap formation

Scientific Reports, 2021
Cardiovascular disease (CVD) is the leading cause of death in patients with chronic kidney disease (CKD). Endothelial cell (EC) dysfunction is a key CKD-specific risk factor; however, the mechanisms by which uremia harms the endothelium are still unclear.
Hoi Woul Lee, Victor Nizet, Jung Nam An, Hyung Seok Lee, Young Rim Song, Sung Gyun Kim, Jwa-Kyung Kim   +6 more
doaj   +1 more source

P-selectin promotes neutrophil extracellular trap formation in mice [PDF]

Blood, 2015
Key Points NET formation is stimulated by platelet or soluble P-selectin.
Etulain, Julia, Martinod, Kimberly, Wong, Siu Ling, Cifuni, Stephen M., Schattner, Mirta Ana, Wagner, Denisa D.   +5 more
openaire   +3 more sources

Neutrophil extracellular traps mediate neuro-immunothrombosis

Neural Regeneration Research
Neutrophil extracellular traps are primarily composed of DNA and histones and are released by neutrophils to promote inflammation and thrombosis when stimulated by various inflammatory reactions.
Jianbo Lou, Jianning Zhang, Quanjun Deng, Xin Chen   +3 more
doaj   +1 more source