Results 61 to 70 of about 36,600 (202)

Genetic variations in A20 DUB domain provide a genetic link to citrullination and neutrophil extracellular traps in systemic lupus erythematosus [PDF]

, 2019
Objectives: Genetic variations in TNFAIP3 (A20) de-ubiquitinase (DUB) domain increase the risk of systemic lupus erythematosus (SLE) and rheumatoid arthritis.
Alexsson, Andrei,, Arthur, Simon,, Bengtsson, Anders,, Cohen, Philip,, Collins, Barry,, Eloranta, Maija Leena,, Gunnarsson, Iva,, Jackson, Sonya,, Jevnikar, Zala,, Johansson, Patrik,, Jönsen, Andreas,, Kastbom, Alf,, Knebel, Axel,, Leonard, Dag,, Lund University., Lund University., Mattsson, Johan,, Nanda, Sambit,, Odqvist, Lina,, Rantapää-Dahlqvist, Solbritt,, Rhedin, Magdalena,, Riise, Rebecca,, Rönnblom, Lars,, Sandling, Johanna K.,, Sjöwall, Christopher,, Svenungsson, Elisabet,, Syvänen, Ann Christine,, Tandre, Karolina,, Thörn, Kristofer,, Vaarala, Outi,, Yrlid, Linda,, Öberg, Lisa,   +31 more
core   +2 more sources

Neutrophil extracellular trap formation and nuclease activity in septic patients

BMC Anesthesiology, 2020
Background There is little knowledge, whether in patients with sepsis neutrophil extracellular trap (NET) formation and NET degrading nuclease activity are altered.
Linda E. Cox, Kai Walstein, Lena Völlger, Friederike Reuner, Alexandra Bick, Annika Dötsch, Andrea Engler, Jürgen Peters, Maren von Köckritz-Blickwede, Simon T. Schäfer   +9 more
doaj   +1 more source

Neutrophil Extracellular Trap Formation Is Independent of De Novo Gene Expression. [PDF]

PLoS ONE, 2016
Neutrophils are essential innate immune cells whose responses are crucial in the clearance of invading pathogens. Neutrophils can respond to infection by releasing neutrophil extracellular traps (NETs).
Gabriel Sollberger, Borko Amulic, Arturo Zychlinsky   +2 more
doaj   +1 more source

Besnoitia besnoiti-induced neutrophil clustering and neutrophil extracellular trap formation depend on P2X1 purinergic receptor signaling

Frontiers in Immunology, 2023
Bovine besnoitiosis is a re-emerging cattle disease caused by the cyst-forming apicomplexan parasite Besnoitia besnoiti. Neutrophil extracellular trap (NET) formation represents an efficient innate immune mechanism of polymorphonuclear neutrophils (PMN ...
Gabriel Espinosa, Iván Conejeros, Lisbeth Rojas-Barón, Carlos Rodrigo Hermosilla, Anja Taubert   +4 more
doaj   +1 more source

Neutrophil stimulation with citrullinated histone H4 slows down calcium influx and reduces NET formation compared with native histone H4.

PLoS ONE, 2021
Peptidylarginine deiminase 4 (PAD4) catalyzes posttranslational modification of many target proteins through converting protein arginine or mono-methylarginine to citrulline.
Lai Shi, Karen Aymonnier, Denisa D Wagner   +2 more
doaj   +1 more source

Wolbachia endosymbionts induce neutrophil extracellular trap formation in human onchocerciasis [PDF]

, 2016
The endosymbiotic bacteria, Wolbachia, induce neutrophilic responses to the human helminth pathogen Onchocerca volvulus. The formation of Neutrophil Extracellular Traps (NETs), has been implicated in anti-microbial defence, but has not been identified in
Edwards, SW, Guimaraes, AF, Johnston, KL, Midgley, A, Pionnier, N, Tamarozzi, F, Taylor, MJ, Turner, JD   +7 more
core   +3 more sources

Aging‐related Atg5 defect impairs neutrophil extracellular traps formation [PDF]

Immunology, 2017
SummaryFormation of neutrophil extracellular traps (NETs) is an important function of the innate immune system against infections. It has been proven that aging dysregulates immunity and impairs neutrophil function. However, the influence of aging on the ability to produce NETs has yet to be fully addressed. In this study, we tested the hypothesis that
Fengying Xu, Chengmi Zhang, Zui Zou, Erica K. Y. Fan, Linsong Chen, Yuehua Li, Timothy R. Billiar, Mark A. Wilson, Xueyin Shi, Jie Fan   +9 more
openaire   +2 more sources

In vitro Demonstration and Quantification of Neutrophil Extracellular Trap Formation

Bio-Protocol, 2017
In the recent decade, neutrophil extracellular traps (NETs) have been identified and confirmed as a new anti-microbial weapon of neutrophils. In this protocol, we describe easy methods to demonstrate NET formation by immunofluorescence staining of ...
Dongsheng Jiang, Mona Saffarzadeh, Karin Scharffetter-Kochanek   +2 more
doaj   +1 more source

P6396LDL cholesterol promotes neutrophil extracellular trap formation

European Heart Journal, 2019
Abstract Background Pro-protein convertase subtilisin/kexin 9 (PCSK9) is a regulator of low density lipoprotein (LDL) receptor (LDLR) expression and has gained attention in the treatment of hyperlipidemia.
A S Ondracek, T M Hofbauer, P P Wadowski, A Mangold, T Gremmel, I M Lang   +5 more
openaire   +1 more source

Targeting the tumor microenvironment in colorectal peritoneal metastases

, 2020
Peritoneal metastasis (PM) occurs in approximately one in four colorectal cancer (CRC) patients. The pathophysiology of colorectal PM remains poorly characterized. Also, the efficacy of current treatment modalities, including surgery and intraperitoneal (
Ceelen, Wim, De Wever, Olivier, Heriot, Alexander G., Narasimhan, Vignesh, Ramsay, Robert G.   +4 more
core   +1 more source