Results 81 to 90 of about 36,600 (202)

A Fragile Balance: Does Neutrophil Extracellular Trap Formation Drive Pulmonary Disease Progression?

Cells, 2021
Neutrophils act as the first line of defense during infection and inflammation. Once activated, they are able to fulfil numerous tasks to fight inflammatory insults while keeping a balanced immune response.
Helena Block, Alexander Zarbock
doaj   +1 more source

Vitamin C: A Novel Regulator of Neutrophil Extracellular Trap Formation [PDF]

Nutrients, 2013
Introduction: Neutrophil extracellular trap (NET) formation was recently identified as a novel mechanism to kill pathogens. However, excessive NET formation in sepsis can injure host tissues. We have recently shown that parenteral vitamin C (VitC) is protective in sepsis. Whether VitC alters NETosis is unknown.
Mohammed, Bassem M., Fisher, Bernard J., Kraskauskas, Donatas, Farkas, Daniela, Brophy, Donald F., Fowler, Alpha A., Natarajan, Ramesh   +6 more
openaire   +2 more sources

Cross-sectional study of proteomic differences between moderate and severe psoriasis

Scientific Reports
Although an ongoing understanding of psoriasis vulgaris (PV) pathogenesis, little is known about the proteomic differences between moderate and severe psoriasis.
Lingling Wu, Chen Cen, Bibo Xie, Lihua Hu, Jia Huang, Ningning Shen, Qiang Dong   +6 more
doaj   +1 more source

Differential Use of Human Neutrophil Fcγ Receptors for Inducing Neutrophil Extracellular Trap Formation

Journal of Immunology Research, 2016
Neutrophils (PMN) are the most abundant leukocytes in the blood. PMN migrate from the circulation to sites of infection, where they are responsible for antimicrobial functions.
Omar Rafael Alemán, Nancy Mora, Ricarda Cortes-Vieyra, Eileen Uribe-Querol, Carlos Rosales   +4 more
doaj   +1 more source

Neutrophil-Targeted Polyphenol-Based Nanoassembly Modulates Nets/Glycolysis For Periodontitis

International Dental Journal
Aim or purpose: Inhibition of neutrophil extracellular trap formation and HK-2-regulated macrophage gated glycolysis for periodontitis treatment Materials and methods: Neutrophil-targeted nanoparticles were synthesized via polyphenol(EGCG)-amino acid(5 ...
Kai Zhang, Xinyi Tang
doaj   +1 more source

Citrullination Licenses Calpain to Decondense Nuclei in Neutrophil Extracellular Trap Formation

Frontiers in Immunology, 2019
Neutrophils respond to various stimuli by decondensing and releasing nuclear chromatin characterized by citrullinated histones as neutrophil extracellular traps (NETs).
Stefanie Gößwein, Aylin Lindemann, Aparna Mahajan, Christian Maueröder, Eva Martini, Jay Patankar, Georg Schett, Christoph Becker, Stefan Wirtz, Nora Naumann-Bartsch, Marco E. Bianchi, Peter A. Greer, Günter Lochnit, Martin Herrmann, Markus F. Neurath, Moritz Leppkes   +15 more
doaj   +1 more source

Heparan sulfate modulates neutrophil and endothelial function in antibacterial innate immunity [PDF]

, 2015
Recently, we showed that endothelial heparan sulfate facilitates entry of a bacterial pathogen into the central nervous system. Here, we show that normal bactericidal activity of neutrophils is influenced by the sulfation pattern of heparan sulfate ...
Brinkmann, Volker, Chang, Yung-Chi, Cole, Jason N, Esko, Jeffrey D, Nizet, Victor, Olson, Joshua, van Wijk, Xander M, Xu, Ding, Zychlinsky, Arturo   +8 more
core   +1 more source

Adenosine receptor agonism protects against NETosis and thrombosis in antiphospholipid syndrome

Nature Communications, 2019
Antiphospholipid syndrome is characterised by increased neutrophil extracellular trap formation (NETosis) and, consequently, increased thrombotic events. Here Ali et al.
Ramadan A. Ali, Alex A. Gandhi, He Meng, Srilakshmi Yalavarthi, Andrew P. Vreede, Shanea K. Estes, Olivia R. Palmer, Paula L. Bockenstedt, David J. Pinsky, Joan M. Greve, Jose A. Diaz, Yogendra Kanthi, Jason S. Knight   +12 more
doaj   +1 more source

Neutrophil extracellular traps mediate transfer of cytoplasmic neutrophil antigens to myeloid dendritic cells toward ANCA induction and associated autoimmunity. [PDF]

, 2012
Antineutrophil cytoplasmic antibodies (ANCAs) target proteins normally retained within neutrophils, indicating that cell death is involved in the autoimmunity process. Still, ANCA pathogenesis remains obscure.
Abdgawad, Alcorta, Barbara Cappetti, Bennett, Bianchi, Brinkmann, Carla Guarnotta, Cassatella, Caterina Vitali, Chin, Claudia Chiodoni, Claudio Tripodo, Clayton, Colombo, Cristiana Guiducci, Di Carlo, Dittmar, Donnelly, Drenkard, Falk, Fuchs, Gaipl, Galeazzi, Garcia-Romo, Gilligan, Griffith, Guiducci, Jarius, Kantari, Kessenbrock, Lande, Manolova, Mariella Parenza, Mario P. Colombo, Martinelli, Metzler, Munafo, Nagata, Nathan, Patrizia Casalini, Patry, Potter, Pradhan, Remijsen, Sabina Sangaletti, Sangaletti, Santiago-Raber, Silvia Piconese, Specks, Spronk, Steinman, Tripodo, van der Geld, van Timmeren, Villanueva, Wernick, Witko-Sarsat, Ziegler-Heitbrock   +57 more
core   +1 more source

Neutrophils in lung cancer patients: Activation potential and neutrophil extracellular trap formation

Research and Practice in Thrombosis and Haemostasis, 2023
Patients with cancer have an increased risk of developing venous thromboembolism. Neutrophils and neutrophil extracellular traps (NETs) reportedly influence the risk of cancer-associated thrombosis. Subpopulations of high and low-density neutrophils (HDN/LDN) are of specific interest, as they might have different functions in cancer patients.We aimed ...
Lisa-Marie, Mauracher, Lena, Hell, Florian, Moik, Moritz, Krall, Cornelia, Englisch, Johanna, Roiß, Ella, Grilz, Thomas M, Hofbauer, Christine, Brostjan, Sylvia, Knapp, Cihan, Ay, Ingrid, Pabinger   +11 more
openaire   +2 more sources