Results 241 to 250 of about 52,667 (297)

Corrigendum to Neutrophil extracellular traps potentiate effector T cells via endothelial senescence in uveitis. [PDF]

JCI Insight
Li Z, Li Z, Hu Y, Xie Y, Shi Y, Chen G, Huang J, Xiao Z, Zhu W, Huang H, Wang M, Chen J, Chen X, Liang D.   +13 more
europepmc   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Neutrophil extracellular traps in rheumatoid arthritis: pathogenic mechanisms and therapeutic potential. [PDF]

Front Immunol
Mao CL, Yu CH, Jiang SL, Ying ZH, Zhu XY.   +4 more
europepmc   +1 more source

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

Myeloperoxidase transforms chromatin into neutrophil extracellular traps. [PDF]

Nature
Burn GL, Raisch T, Tacke S, Winkler M, Prumbaum D, Thee S, Gimber N, Raunser S, Zychlinsky A.   +8 more
europepmc   +1 more source

Defining AV2‐1 as a novel pharmacological probe to target human and rodent TRPV2

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Transient receptor potential vanilloid 2 (TRPV2) is a non‐selective cation channel implicated in immune cell functions. However, progress in understanding TRPV2 has been limited by a lack of potent and selective pharmacological tools, particularly those targeting the human variant. We aimed to identify and characterise a
Andrea Leipe, Julia A. Rocereta, Ruth A. Pumroy, Andreas Leffler, Michael Schaefer, Vera Moiseenkova‐Bell, Kerstin Hill   +6 more
wiley   +1 more source

Global research status of the impact of neutrophil extracellular traps on tumor from 2004 to 2023: A bibliometric and visualized analysis. [PDF]

Medicine (Baltimore)
Wang X, Wang Y, Yang Y, Wu C, Zhuo E, Yin M, Zhou M, Gu K, Chen B, Jia Y.   +9 more
europepmc   +1 more source

Inherited p40phox deficiency differs from classic chronic granulomatous disease [PDF]

, 2018
Dinauer, Mary C, et al,
core   +1 more source

Advancements in Inorganic Chiral Nanomaterials for Anti‐Tumor Immunotherapy

Cancer Science, EarlyView.
Schematic illustration of how inorganic chiral nanomaterials enhance immune activation to promote tumor cell elimination through targeted delivery, immunogenic cell death, and immune microenvironment modulation. ABSTRACT While the past decade has witnessed unprecedented technological advancements, cancer remains a major health threat, with conventional
Siyu Chen, Qian Tang, Xiqian Chen, Yinghao Liang, Jin Qiu, Yongmei Liao, Changqiang Li, Hongru Yu, Fang Xie, Zongjunlin Liu   +9 more
wiley   +1 more source

Research progress on neutrophil extracellular traps and hepatitis-to-hepatocellular carcinoma transformation (Review). [PDF]

Oncol Lett
Wang Y, Zhang C, Wang H, Zhou Y, Yu Y, Liu H, Gu C.   +6 more
europepmc   +1 more source