Results 301 to 310 of about 75,140 (320)

Neutrophil extracellular traps predict poor response and prognosis in non-small cell lung cancer immunotherapy. [PDF]

Ther Adv Med Oncol
Lv J, Chen X, Zhang R, Wang C, Yu J, Yan W, Chen D.   +6 more
europepmc   +1 more source

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Neutrophil Extracellular Traps Kill Bacteria

Science, 2004
Neutrophils engulf and kill bacteria when their antimicrobial granules fuse with the phagosome. Here, we describe that, upon activation, neutrophils release granule proteins and chromatin that together form extracellular fibers that bind Gram-positive and -negative bacteria. These neutrophil extracellular traps (NETs) degrade virulence factors and kill
V. Brinkmann, U. Reichard, C. Goosmann, B. Fauler, Yvonne Uhlemann, D. Weiss, Y. Weinrauch, A. Zychlinsky   +7 more
semanticscholar   +5 more sources

Neutrophil extracellular traps in cancer

Seminars in Cancer Biology, 2022
Beyond their well-known functions in the acute phases of the immune response, neutrophils play important roles in the various phases of tumor initiation and progression, through the release of their stored or newly synthesized mediators. In addition to reactive oxygen species, cytokines, chemokines, granule proteins and lipid mediators, neutrophil ...
Leonardo Cristinziano, Luca Modestino, Alessandro Antonelli, Gianni Marone, Hans-Uwe Simon, Gilda Varricchi, Maria Rosaria Galdiero   +6 more
openaire   +3 more sources

Rethinking neutrophil extracellular traps

International Immunopharmacology, 2023
Neutrophils are a major subset of leukocytes in human circulating blood. In some circumstances, neutrophils release neutrophil extracellular traps (NETs). lnitially, NETs were considered to have a strong antibacterial capacity. However, currently, NETs have been shown to have a pivotal impact on various diseases.
Yi Liu, Yu-hua Ma, Jian-wei Yang, Jiang-wei Man, Hua-bin Wang, Yi Li, Cheng Liang, Jin-long Cao, Si-yu Chen, Kun-peng Li, Li Yang   +10 more
openaire   +2 more sources

Neutrophil extracellular traps: neutrophil’s afterlife

Hirurg (Surgeon), 2021
This paper is a literature review on the origin, structure and functioning of neutrophil extracellular traps (NETs) that are released from neutrophils through NETosis, the kind of cell death. NETs are comprised of DNA, histones and neutrophil granule enzymes.
Olga Yaroslavna Porembskaya, Kirill Victorovich Lobastov, Viacheslav Nikolaevich Kravchuk, Irina Vladimirovna Gritskova, Leonid Alexandrovich Laberko, Mikhail Shakirovich Chesnokov, Grigory Vladimirovich Rodoman, Sergey Anatolievich Sayganov   +7 more
openaire   +1 more source

Extracellular neutrophil traps in periodontitis

Journal of Periodontal Research, 2009
Background and Objective:  Chronic periodontitis, the chronic inflammatory disease of the periodontium, is caused by bacteria and is characterized by an influx of neutrophils into the gingival crevice. Recently, a ‘new’ extracellular neutrophil defense mechanism – neutrophil extracellular traps – has been described. However, their role in periodontitis
L, Vitkov, M, Klappacher, M, Hannig, W D, Krautgartner   +3 more
openaire   +2 more sources

Neutrophil extracellular traps mediate bone erosion in rheumatoid arthritis by enhancing RANKL‐induced osteoclastogenesis

British Journal of Pharmacology, 2023
Rheumatoid arthritis (RA) is a chronic autoimmune disease that can cause bone erosion due to increased osteoclastogenesis. Neutrophils involvement in osteoclastogenesis remains uncertain.
A. Schneider, T. M. Taira, G. Públio, Douglas da Silva Prado, Paula Barbim Donate Yabuta, Jéssica Cristina dos Santos, C. Machado, F. D. de Souza, Lucas Gabriel R Venturini, R. D. de Oliveira, T. Cunha, J. Alves-Filho, P. Louzada-Júnior, T. D. da Silva, S. Fukada, F. Cunha   +15 more
semanticscholar   +1 more source

Neutrophil Extracellular Traps in Sepsis

Shock, 2014
Sepsis is the leading cause of death in critically ill patients in intensive care units. Early recognition of sepsis and proper therapy are essential to reduce patient mortality. Moreover, treatment options for this deleterious inflammatory response to infection are limited.
Camicia, Gabriela Lorena, Pozner, Roberto Gabriel, de Larrañaga, Gabriela Fernanda   +2 more
openaire   +3 more sources

Neutrophil extracellular traps in the pathology of cancer and other inflammatory diseases.

Physiological Reviews, 2022
Neutrophil extracellular trap (NET) formation, first described in 2004 as a previously unknown strategy of neutrophils to fight microbes, has attracted an increasing interest in the research community.
M. Herre, J. Cedervall, N. Mackman, A. Olsson   +3 more
semanticscholar   +1 more source

Gasdermin D plays a vital role in the generation of neutrophil extracellular traps

Science immunology, 2018
By screening a library of compounds that block NETosis, we have identified a gasdermin D inhibitor. Casting NETs Gasdermin D (GSDMD), a pore-forming protein, has emerged as a key downstream effector in pyroptosis, a form of cell death induced by ...
G. Sollberger, A. Choidas, G. Burn, Peter Habenberger, R. Di Lucrezia, Susanne Kordes, Sascha Menninger, J. Eickhoff, P. Nussbaumer, B. Klebl, R. Krüger, A. Herzig, A. Zychlinsky   +12 more
semanticscholar   +1 more source