Results 61 to 70 of about 75,140 (320)

Neutrophil extracellular traps and pulmonary fibrosis: an update

Journal of Inflammation, 2023
Pulmonary fibrosis (PF) is a serious and often fatal illness that occurs in various clinical settings and represents a significant unmet medical need. Increasing evidence indicates that neutrophil extracellular traps (NETs) contribute significantly to ...
Suyan Yan, Meiqi Li, Baocheng Liu, Zhenzhen Ma, Qingrui Yang   +4 more
semanticscholar   +1 more source

Platelets: New bricks in the building of neutrophil extracellular traps [PDF]

, 2016
In addition to being key elements in hemostasis and thrombosis, platelets have an important role in the inflammatory and innate immune response. This activity is associated with their capability to recognize pathogens through the expression of toll-like ...
Carestia, Agostina, Kaufman, Tomás, Schattner, Mirta Ana   +2 more
core   +1 more source

Neutrophil extracellular traps regulate ischemic stroke brain injury

Journal of Clinical Investigation, 2022
Ischemic stroke prompts a strong inflammatory response, which is associated with exacerbated outcomes. In this study, we investigated mechanistic regulators of neutrophil extracellular trap (NET) formation in stroke and whether they contribute to stroke ...
F. Denorme, Irina Portier, J. Rustad, M. Cody, C. D. de Araujo, Chieko Hoki, M. Alexander, R. Grandhi, Mitchell R. Dyer, M. Neal, J. Majersik, C. Yost, Robert A. Campbell   +12 more
semanticscholar   +1 more source

Neutrophil Extracellular Traps Orchestrate Necroinflammation [PDF]

Journal of the American Society of Nephrology, 2017
In 1869, a young Swiss student who was interested in the study of the nuclei of cells succeeded in separating the nuclei from the cytoplasm of white blood cell from pus, which he obtained from discarded surgical bandages from the local surgical clinic.[1][1] He found that the nuclei were made of ...
openaire   +2 more sources

Neutrophil extracellular traps — the dark side of neutrophils [PDF]

Journal of Clinical Investigation, 2016
Neutrophil extracellular traps (NETs) were discovered as extracellular strands of decondensed DNA in complex with histones and granule proteins, which were expelled from dying neutrophils to ensnare and kill microbes. NETs are formed during infection in vivo by mechanisms different from those originally described in vitro. Citrullination of histones by
Sørensen, Ole E., Borregaard, Niels
openaire   +3 more sources

Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice

Science, 2018
Waking up in a trap Cancer patients who have undergone successful treatment can experience relapse of their disease years or even decades later. This is because cancer cells that have disseminated beyond the primary tumor site enter a state of dormancy ...
Jean Albrengues, M. Shields, David Ng, Chun Gwon Park, A. Ambrico, M. Poindexter, P. Upadhyay, D. Uyeminami, Arnaud Pommier, Victoria Küttner, Emilis Bružas, L. Maiorino, Carmelita Bautista, Ellese M. Carmona, P. Gimotty, D. Fearon, K. Chang, S. Lyons, K. Pinkerton, L. Trotman, Michael S. Goldberg, J. Yeh, M. Egeblad   +22 more
semanticscholar   +1 more source

Neutrophil extracellular traps mediate m6A modification and regulates sepsis-associated acute lung injury by activating ferroptosis in alveolar epithelial cells

International Journal on Biological Sciences, 2022
Neutrophil extracellular traps (NETs) production is a major strategy employed by polymorphonuclear neutrophils (PMNs) to fight against microbes. NETs have been implicated in the pathogenesis of various lung injuries, although few studies have explored ...
Hao Zhang, Jinlong Liu, Yilu Zhou, Mengdi Qu, Yang Wang, K. Guo, Ruling Shen, Zhirong Sun, J. Cata, Shuofei Yang, Wankun Chen, C. Miao   +11 more
semanticscholar   +1 more source

Neutrophil Extracellular Traps Formation and Aggregation Orchestrate Induction and Resolution of Sterile Crystal-Mediated Inflammation

Frontiers in Immunology, 2018
The formation of neutrophil extracellular traps (NETs) to immobilize pathogens represents a novel antimicrobial strategy of the immune system. The microcrystals related to human diseases are classified into endogenous microcrystals, including monosodium ...
Yanhong Li, Xue Cao, Yi Liu, Yi Zhao, Yi Zhao, Martin Herrmann   +5 more
doaj   +1 more source

Stroke-derived neutrophils demonstrate higher formation potential and impaired resolution of CD66b + driven neutrophil extracellular traps

BMC Neurology, 2022
Background Recent evidence suggests a merging role of immunothrombosis in the formation of arterial thrombosis. Our study aims to investigate its relevance in stroke patients. Methods We compared the peripheral immunological profile of stroke patients vs.
Angeliki Datsi, Laura Piotrowski, Markella Markou, Thomas Köster, Isabelle Kohtz, Kerstin Lang, Sabine Plöttner, Heiko Udo Käfferlein, Burkhard Pleger, Ramon Martinez, Bogdan Pintea, Roland Fried, Marcus Müller, Rene Chapot, Konstantinos Gousias   +14 more
doaj   +1 more source

Neutrophil extracellular traps in central nervous system pathologies: A mini review

Frontiers in Medicine, 2023
Neutrophils are the first cells to be recruited to sites of acute inflammation and contribute to host defense through phagocytosis, degranulation and neutrophil extracellular traps (NETs).
Areez Shafqat, Ahmed Noor Eddin, Ghaith Adi, Mohammed Al-Rimawi, Saleha Abdul Rab, Mylia Abu-Shaar, Kareem Adi, Khaled Alkattan, Ahmed Yaqinuddin   +8 more
semanticscholar   +1 more source