Results 61 to 70 of about 52,667 (297)

Targeting the tumor microenvironment in colorectal peritoneal metastases

, 2020
Peritoneal metastasis (PM) occurs in approximately one in four colorectal cancer (CRC) patients. The pathophysiology of colorectal PM remains poorly characterized. Also, the efficacy of current treatment modalities, including surgery and intraperitoneal (
Ceelen, Wim, De Wever, Olivier, Heriot, Alexander G., Narasimhan, Vignesh, Ramsay, Robert G.   +4 more
core   +1 more source

Conflicting interests in the pathogen-host tug of war : fungal micronutrient scavenging versus mammalian nutritional immunity [PDF]

, 2014
Funding: The authors are supported by the European Research Council (STRIFE project funded on grant number ERC-2009-AdG-249793, http://erc.europa.eu). AJPB is also supported by the Wellcome Trust (grant numbers 080088, 097377, www.wellcome.ac.uk) and the
Ballou, Elizabeth R, Brown, Alistair J P, Childers, Delma S, Potrykus, Joanna   +3 more
core   +2 more sources

Changes in Immune‐Inflammation Status and Acute Ischemic Stroke Prognosis in Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Inflammation is a critical risk factor for poor outcomes in cerebral infarction. Prior studies focused primarily on baseline inflammation status, neglecting dynamic longitudinal changes. We try to investigate the association between immune‐inflammation status alterations and stroke prognosis, and evaluated three systemic biomarkers'
Songfang Chen, Wenting Huang, Yitian Liu, Xuan Chen, Buyu Ke, Qian Shen, Hanyu Cai, Jing Sun, Yan Li, Yungang Cao, Beilei Hu, Keyang Chen   +11 more
wiley   +1 more source

IV Thrombolysis Facilitates Interventional Reperfusion in Non‐Cardioembolic but Not Cardioembolic Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intravenous thrombolysis (IVT) before thrombectomy for ischemic stroke may alter clot structure and procedural performance. We investigated how IVT relates to thrombectomy metrics across stroke etiologies. Methods We performed a time‐to‐event analysis of consecutive patients with anterior circulation large vessel occlusion (acLVO ...
Annahita Sedghi, Daniel P. O. Kaiser, Martin Arndt, Norma J. Diel, Erik Simon, Witold H. Polanski, Volker Puetz, Hagen B. Huttner, Timo Siepmann   +8 more
wiley   +1 more source

Mucosa-Environment Interactions in the Pathogenesis of Rheumatoid Arthritis [PDF]

, 2019
Mucosal surfaces play a central role in the pathogenesis of rheumatoid arthritis (RA). Several risk factors, such as cigarette smoking, environmental pollution, and periodontitis interact with the host at the mucosal level, triggering immune system ...
Conti, Fabrizio, Di Franco, Manuela, Guzzo, Maria Paola, Iannuccelli, Cristina, Lucchino, Bruno, Spinelli, Francesca Romani   +5 more
core   +1 more source

Neutrophil extracellular traps in COVID-19 [PDF]

JCI Insight, 2020
In severe cases of coronavirus disease 2019 (COVID-19), viral pneumonia progresses to respiratory failure. Neutrophil extracellular traps (NETs) are extracellular webs of chromatin, microbicidal proteins, and oxidant enzymes that are released by neutrophils to contain infections.
Yu Zuo, Srilakshmi Yalavarthi, Hui Shi, Kelsey Gockman, Melanie Zuo, Jacqueline A. Madison, Christopher N. Blair, Andrew Weber, Betsy J. Barnes, Mikala Egeblad, Robert J. Woods, Yogendra Kanthi, Jason S. Knight   +12 more
openaire   +2 more sources

Dense Nanofibrillar Collagen–Silica Hybrids with High Strength and ECM‐Mimetic Tissue Integration

Advanced Functional Materials, EarlyView.
Dense nanofibrillar collagen–silica hybrids are engineered by synchronizing collagen fibrillogenesis with silica condensation, producing printable scaffolds that unexpectedly approach native extracellular matrix organization and strength. These cell‐free constructs guide endogenous cell‐infiltration, enable localized matrix remodeling, and integrate ...
Norein Norein, Shima Tavakoli, Philipp Wolf, Xie Ling, Veronica Rondahl, Klaus Leifer, Gry Hulsart‐Billström, Jöns Hilborn   +7 more
wiley   +1 more source

Neutrophil extracellular traps in urinary tract infection

Frontiers in Pediatrics, 2023
BackgroundUrinary tract infections (UTI) are common types of bacterial infection in children. UTI treatment is aimed to prevent complications including hypertension, proteinuria, and progression to chronic kidney disease.
Katarína Krivošíková, Nadja Šupčíková, Alexandra Gaál Kovalčíková, Alexandra Gaál Kovalčíková, Jakub Janko, Michal Pastorek, Peter Celec, Peter Celec, Ľudmila Podracká, Ľubomíra Tóthová   +9 more
doaj   +1 more source

Neutrophil extracellular traps are associated with disease severity and microbiota diversity in patients with chronic obstructive pulmonary disease [PDF]

, 2017
BACKGROUND: Neutrophil extracellular traps (NETs) have been observed in the airway in COPD, but their clinical and pathophysiological implications have not been defined.OBJECTIVE: To determine if NETs are associated with disease severity in COPD, and how
Agusti, Alison J. Dicker, Andrew J. Cassidy, Bafadhel, Branzk, Brinkmann, Calverley, Caporaso, Caudrillier, Celli, Christopher J. Fong, Colin N.A. Palmer, Dickson, Donnelly, Dworski, Eleanor G. Pumphrey, Elizabeth Furrie, Farnworth, Flynn, Gill Brady, Gisli G. Einarsson, Grabcanovic-Musija, Gray, Greenwood, Guillermo Suarez-Cuartin, Haslett, Hoenderdos, J. Stuart Elborn, James D. Chalmers, Jiang, Juneau, Kessenbrock, Khandpur, Knight, Lange, Leidy, Lozano, Megan L. Crichton, Menegazzi, Metzler, Morris, Obermayer, Oriol Sibila, Papayannopoulos, Pascoe, Pavord, Pedersen, Richens, Sara E. Marshall, Savill, Sayah, Short, Speizer, Stuart Schembri, Vestbo, Wasyla Ibrahim, Willemse, Yipp, Zabieglo   +58 more
core   +2 more sources

Neutrophil extracellular traps in fungal infection [PDF]

Seminars in Cell & Developmental Biology, 2019
Fungal infections are a continuously increasing problem in modern health care. Understanding the complex biology of the emerging pathogens and unraveling the mechanisms of host defense may form the basis for the development of more efficient diagnostic and therapeutic tools. Neutrophils play a pivotal role in the defense against fungal pathogens. These
Constantin F, Urban, Jeniel E, Nett
openaire   +2 more sources