Results 101 to 110 of about 194,382 (299)

Neutrophils in HNSCC Can Be Associated with Both a Worse or Favorable Prognosis

Biomolecules
The prognostic significance of tumor-infiltrating neutrophils in head and neck squamous cell carcinoma (HNSCC) is poorly understood. It is unclear how the presence of neutrophils affects prognosis due to their polarization into cytotoxic N1 or ...
Hendrik Brunkhorst, Sören Schnellhardt, Maike Büttner-Herold, Christoph Daniel, Rainer Fietkau, Luitpold V. Distel   +5 more
doaj   +1 more source

Skap2 is required for β2 integrin-mediated neutrophil recruitment and functions. [PDF]

, 2017
Integrin activation is required for neutrophil functions. Impaired integrin activation on neutrophils is the hallmark of leukocyte adhesion deficiency (LAD) syndrome in humans, characterized by impaired leukocyte recruitment and recurrent infections. The
Bardel, Bernadette, Block, Helena, Bokemeyer, Arne, Boras, Mark, Heitplatz, Barbara, Kliche, Stefanie, Lowell, Clifford, Reinhold, Annegret, Rossaint, Jan, Van Marck, Veerle, Volmering, Stephanie, Zarbock, Alexander   +11 more
core   +2 more sources

Simvastatin Restores Uteroplacental Hemodynamics and Trophoblast Function in Obstetric Antiphospholipid Syndrome in a Placenta‐on‐a‐Chip Model

Advanced Healthcare Materials, EarlyView.
Simvastatin mitigates placental hypoperfusion in OAPS by ameliorating abnormal uteromaternal hemodynamics and enhancing trophoblast invasion via optimized endothelial cell interactions under pathological shear stress, as evidenced by results from a placenta‐on‐a‐chip platform.
Hongli Liu, Yuan Wang, Yanjun Cai, Ruixin Guo, Shunhua Liu, Tingting Chen, Tingting Sun, Ruiheng Huo, Tengwei Liu, Qingfeng Lv, Xietong Wang   +10 more
wiley   +1 more source

(-)-Epigallocatechin-3-gallate Reduces Cigarette Smoke-Induced Airway Neutrophilic Inflammation and Mucin Hypersecretion in Rats

Frontiers in Pharmacology, 2017
Background: Cigarette smoking is the leading cause of chronic obstructive pulmonary disease. (-)-Epigallocatechin-3-gallate (EGCG), the major catechins in Chinese green tea, has been studied for its anti-oxidative and anti-inflammatory properties in cell
Yingmin Liang, Yingmin Liang, Yingmin Liang, Kenneth W. K. Liu, Kenneth W. K. Liu, Sze C. Yeung, Sze C. Yeung, Xiang Li, Xiang Li, Mary S. M. Ip, Mary S. M. Ip, Mary S. M. Ip, Judith C. W. Mak, Judith C. W. Mak, Judith C. W. Mak, Judith C. W. Mak   +15 more
doaj   +1 more source

Preoperative neutrophil-lymphocyte ratio and outcome from coronary artery bypass grafting [PDF]

, 2007
Background: An elevated preoperative white blood cell count has been associated with a worse outcome after coronary artery bypass grafting (CABG). Leukocyte subtypes, and particularly the neutrophil-lymphocyte (N/L) ratio, may however, convey superior ...
Buchan, Keith G., Croal, Bernard L., Cuthbertson, Brian, El-Shafei, Hussein, Gibson, George, Gibson, Patrick H., Hillis, Graham S., Ifezulike, Ada I., Jeffrey, Robert R., Small, Gary R.   +9 more
core   +1 more source

SLPI controls neutrophil migration abilities and impacts neutrophil skin infiltration in experimental psoriasis

Cellular and Molecular Life Sciences
Abstract Skin infiltration by neutrophils is a hallmark of the chronic inflammatory skin disease psoriasis, yet the mechanisms underlying neutrophil recruitment and positioning in chronically inflamed skin remain poorly understood. In this study, we demonstrate the significant impact of a total genetic deficiency of secretory leukocyte ...
Patrycja Kwiecinska, Michal Santocki, Joanna Skrzeczynska-Moncznik, Ivan Sinkevich, Katarzyna Piwowarczyk, Pawel Majewski, Beata Grygier, Monika Majchrzak-Gorecka, Jaroslaw Czyz, Elzbieta Kolaczkowska, Joanna Cichy   +10 more
openaire   +3 more sources

Enhancement of neutrophil infiltration in histidine decarboxylase‐deficient mice

Immunology, 2002
SummaryThe roles of histamine in the anaphylactic increase in vascular permeability and leucocyte infiltration were analysed in an air pouch‐type allergic inflammation model in histidine decarboxylase‐deficient (HDC−/−) mice and wild‐type mice. In the immunized wild‐type mice, histamine content in the pouch fluid and vascular permeability in the ...
Noriyasu, Hirasawa, Hiroshi, Ohtsu, Takehiko, Watanabe, Kazuo, Ohuchi   +3 more
openaire   +3 more sources

Hybrid Nanofibers for Multimodal Accelerated Wound Healing

Advanced Healthcare Materials, EarlyView.
Fabrication of wound healing scaffolds based on biocompatible nanofibers. Nanofibers offering high surface area, flexibility, and biocompatibility significantly improved the healing outcome in vivo. Histological, immunological, and anti‐inflammatory markers are noticeably better in treated wounds.
Viraj P. Nirwan, Bence Bajusz, Norbert Fabók, Marina Rudan Dimlic, Jelena Budimir, Tshepang Mqatywa, Miklós Gyöngy, Márton Ferencz, Dorottya Kocsis, Olexandr Bondarenko, Mariia Rolduhina, Milena Lengyel, Istvan Antal, Rebecca Hengsbach, Franciska Erdő, Amir Fahmi   +15 more
wiley   +1 more source

Advanced 3D Platforms for Modeling CNS Neuroinflammation: Cell Integration, Techniques, and Challenges

Advanced Healthcare Materials, EarlyView.
This review summarizes the roles of key central nervous system cell types, the extracellular matrix, and the blood‐brain barrier in neuroinflammation, and their integration into diverse 3D culture systems. It examines major incorporation strategies, including direct co‐culture, hydrogel encapsulation, transwell migration assays, and bioprinting ...
Emmanuelle D. Aiyegbusi, Julia Di Stefano, Dearbhaile Dooley   +2 more
wiley   +1 more source

Hematologic Toxicity of Concurrent Administration of Radium-223 and Next-generation Antiandrogen Therapies. [PDF]

, 2017
PURPOSE/OBJECTIVES: Radium-223 is a first-in-class radiopharmaceutical recently approved for the treatment of castration-resistant prostate cancer in patients with symptomatic bone metastases.
Basch, Beer, Chen, Cookson, De Bono, Den, Dreicer, Fizazi, Hoskin, Kantoff, Keizman, Morris, Nilsson, Nilsson, Parker, Petrylak, Ryan, Scher, Siegel, Tannock, Tu   +20 more
core   +2 more sources