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Detecting Migration and Infiltration of Neutrophils in Mice

Journal of Visualized Experiments, 2020
Neutrophils are a major member of the innate immune system and play pivotal roles in host defense against pathogens and pathologic inflammatory reactions. Neutrophils can be recruited to inflammation sites via the guidance of cytokines and chemokines.
Qingyi, Lu   +7 more
openaire   +2 more sources

Elastase expression by infiltrating neutrophils in gliomas

Neurological Research, 2000
Polymorphonuclear neutrophil elastase is a neutral protease released by activated polymorphonuclear neutrophils and plays a crucial role in maintaining host defense. However, under certain conditions, this enzyme damages normal tissue and facilitates infiltration of tumor cells.
K, Iwatsuki   +5 more
openaire   +2 more sources

Quantitation of neutrophil infiltration in vivo

Immunology Letters, 1979
Abstract Neutrophils accumulate at sites of inflammation and infection. This report describes a method for quantitative neutrophil accumulation at such sites in vivo in rabbits by using chromium-51 labelled rabbit blood neutrophils.
Andrew C. Issekutz, Henry Z. Movat
openaire   +1 more source

Neutrophil Infiltration and Chemokines

Critical Reviews™ in Immunology, 2006
Neutrophil infiltration is mainly mediated by ELR+ CXC chemokines and is regulated through interactions between various stimulants and cells, which are perhaps more complex than previously thought. In this review, I describe the current view of the roles of neutrophil-selective chemokines such as IL-8, MIP-2, and KC by choosing several in vivo models ...
openaire   +2 more sources

Hyaluronidase decreases neutrophils infiltration to the inflammatory site

Inflammation Research, 2016
To evaluate the in vivo anti-inflammatory potential of bovine hyaluronidase (HYAL) using two different models of acute inflammation.Air pouches were produced in the dorsal subcutaneous of mice and injected with phosphate saline solution or HYAL. The antiinflammatory action of HYAL was evaluated in carrageenan (Cg)-inflamed air pouches. After 4 and 24 h
Fronza, Marcio   +8 more
openaire   +3 more sources

Neutrophilic infiltration in alcoholic hepatitis

Alcohol, 2002
Leukocyte infiltration in the liver is one of the most important features of alcoholic liver disease. However, in alcoholic hepatitis, the role of polymorphonuclear neutrophils (PMNs) in liver injury still remains to be fully elucidated. Furthermore, the migration of PMNs and their presence in the liver during alcoholic hepatitis have not been fully ...
openaire   +2 more sources

Elastase, a marker for neutrophils in skin infiltrates

British Journal of Dermatology, 1986
The enzyme elastase (EC 3.4.21.37) has proved to be a convenient and extremely sensitive marker for the quantification of neutrophils in cutaneous infiltrates. Fluorometric assay using the synthetic substrate MeOSuc-Ala-Ala-Pro-Val-N-methylcoumarin permitted the measurement of this enzyme in as few as five cells and was linear up to about 1000 cells ...
A M, Lammers   +3 more
openaire   +2 more sources

Vasculitides, Vasculopathies, and Neutrophilic Infiltrates

2017
Alterations in dermal blood vessels occur as primary cutaneous disorders and more frequently as a manifestation of a systemic process. Inflammation of vessel walls can occur within capillaries, post-capillary venules or cutaneous arteries and at all levels of the dermis and subcutis.
Thuy L. Phung   +3 more
openaire   +1 more source

Leukotriene Generation and Neutrophil Infiltration After Experimental Acute Pancreatitis

Inflammation, 1998
The role of 5-lipoxygenase metabolites of arachidonic acid in the inflammatory response associated with experimental acute pancreatitis has been evaluated. For this purpose, an experimental necrohemorrhagic pancreatitis was induced in rats by intraductal administration of 5% sodium taurocholate. Neutrophil infiltration was detected in pancreas at 1 and
Folch-Puy, Emma   +4 more
openaire   +3 more sources

Chemotherapy‐associated eccrine hidradenitis: Neutrophilic eccrine hidradenitis reevaluated: The role of neutrophilic infiltration

Medical and Pediatric Oncology, 1988
AbstractTwo cases of chemotherapy‐associated eccrine hidradenitis are presented. Previous cases have been labeled “neutrophilic eccrine hidradenitis” (NEH). Both cases reported herein involve neutropenic patients and are notable for the absence of neutrophils on histologic examination.
B H, Greenbaum   +4 more
openaire   +2 more sources

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