Results 31 to 40 of about 194,382 (299)

Vaginal neutrophil infiltration is contingent on ovarian cycle phase and independent of pathogen infection

Frontiers in Immunology, 2022
The mucosa of the female reproductive tract must reconcile the presence of commensal microbiota and the transit of exogenous spermatozoa with the elimination of sexually transmitted pathogens.
M. C. Latorre, C. Gómez‐Oro, I. Olivera‐Valle, E. Blazquez‐Lopez, J. Gallego‐Valle, A. Ibañez‐Escribano, P. Casesnoves, C. González‐Cucharero, M. A. Muñoz‐Fernandez, L. Sanz, J. Vaquero, P. Martín‐Rabadań, F. Perez‐Milan, F. Perez‐Milan, M. Relloso   +14 more
doaj   +1 more source

Role of p38 mitogen-activated protein kinase isoforms in murine skin inflammation induced by 12-O-tetradecanoylphorbol 13-acetate [PDF]

, 2011
p38 mitogen-activated protein kinase plays a pivotal role in skin inflammation. The purpose of this study was to investigate the role of the various p38 isoforms. p38 beta/delta-knockout-C57BL/6 mice were generated, studied in a 12-O-tetradecanoylphorbol
Arthur, J. Simon C., Bibby, Bo Martin, Funding, Anne, Iversen, Lars, Johansen, Claus, Kragballe, Knud, Lilleholt, Louise Langer   +6 more
core   +3 more sources

Proteolytic Degradation Is a Major Contributor to Bioprosthetic Heart Valve Failure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Whereas the risk factors for structural valve degeneration (SVD) of glutaraldehyde‐treated bioprosthetic heart valves (BHVs) are well studied, those responsible for the failure of BHVs fixed with alternative next‐generation chemicals remain ...
Alexander E. Kostyunin, Tatiana V. Glushkova, Arseniy A. Lobov, Evgeny A. Ovcharenko, Bozhana R. Zainullina, Leo A. Bogdanov, Daria K. Shishkova, Victoria E. Markova, Maksim A. Asanov, Rinat A. Mukhamadiyarov, Elena A. Velikanova, Tatiana N. Akentyeva, Maria A. Rezvova, Alexander N. Stasev, Alexey V. Evtushenko, Leonid S. Barbarash, Anton G. Kutikhin   +16 more
doaj   +1 more source

Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors. [PDF]

, 2017
Tumor-associated macrophages (TAM) contribute to all aspects of tumor progression. Use of CSF1R inhibitors to target TAM is therapeutically appealing, but has had very limited anti-tumor effects.
Albert Lo, Andrey Loboda, Ashani T. Weeraratna, Ayumi Hashimoto, Brian Nam, Butowski, Carus, Challacombe, Chao, Charles Mulligan, Chunsheng Zhang, Condamine, Conway, Coussens, David W. Speicher, DeNardo, Dmitry I. Gabrilovich, Douglas Marvel, Ellen Puré, Fang Wang, Fearon, Feig, Finke, Fred Denstman, Gabrilovich, Gabrilovich, Gascard, Genovese, Gentles, Greenberg, Grivennikov, Guleria, Huang, Kato, Kumar, Ladanyi, Laxminarasimha Donthireddy, Lin, Linda A. Snyder, Lo, Lokeshwar, Lucas, Lucia R. Languino, MacDonald, Manuel A. Sepulveda, Mao, Marlee A. Goins, Messmer, Meyer, Mishra, Mitchem, Mok, Mok, Neil Hockstein, Newman, Noman, Obermajer, Ohno, Orimo, Peter Ordentlich, Pixley, Prashanthi Vonteddu, Pyonteck, Qin Liu, Ramachandran, Reeti Behera, Ries, Ries, Robert H. Vonderheide, Sasse, Sergio Lavilla-Alonso, Shanti Shakamuri, Sionov, Sluijter, Solito, Strachan, Szkandera, Talmadge, Tap, Thomas Condamine, Timothy Chao, Vetsika, Vinit Kumar, Wang, Weber, Xiaowei Xu, Xu, Yang, Zhang, Zhang, Zhu   +90 more
core   +2 more sources

Distinct Characteristics of Sweet’s Syndrome of the Scrotum Caused by All-trans Retinoic Acid in a Patient with Acute Promyelocytic Leukemia

Case Reports in Oncology, 2021
Induction therapy with all-trans retinoic acid (ATRA) is effective for acute promyelocytic leukemia (APL). ATRA induces neutrophil differentiation and its associated side effects.
Osamu Imataki, Shunsuke Yoshida, Tomohiro Kaji, Jun-ichiro Kida, Hiroyuki Kubo, Makiko Uemura, Haruyuki Fujita, Norimitsu Kadowaki   +7 more
doaj   +1 more source

Target-Specific Fluorescence-Mediated Tomography for Non-Invasive and Dynamic Assessment of Early Neutrophil Infiltration in Murine Experimental Colitis

Cells, 2019
The role of neutrophils in the pathogenesis of inflammatory bowel disease (IBD) is still only incompletely understood. Here, we evaluated target-specific fluorescence-mediated tomography (FMT) for visualization of neutrophil infiltration in murine ...
Tobias M. Nowacki, Philipp Lenz, Dominik Bettenworth, Markus Brückner, Arne Bokemeyer, Phil R. Tepasse, Anne Helfen, Moritz Wildgruber, Michel Eisenblätter   +8 more
doaj   +1 more source

The Actin-Binding Protein Cortactin Promotes Sepsis Severity by Supporting Excessive Neutrophil Infiltration into the Lung

Biomedicines, 2022
Sepsis is a systemic infection that can lead to multi-organ failure. It is characterised by an uncontrolled immune response with massive neutrophil influx into peripheral organs. Neutrophil extravasation into tissues depends on actin remodeling and actin-
Nathaniel L. Lartey, Hilda Vargas-Robles, Idaira M. Guerrero-Fonseca, Alexander García-Ponce, Citlaltepetl Salinas-Lara, Klemens Rottner, Michael Schnoor   +6 more
doaj   +1 more source

Intracapillary leucocyte accumulation as a novel antihaemorrhagic mechanism in acute pancreatitis in mice [PDF]

, 2009
Background: Pancreatic infiltration by leucocytes represents a hallmark in acute pancreatitis. Although leucocytes play an active role in the pathophysiology of this disease, the relation between leucocyte activation, microvascular injury and haemorrhage
Deduchovas, O., Hartwig, W., Kerkadze, V., Märten, A., Parseliunas, A., Ryschich, E., Salnikova, O., Schmidt, J., Sperandio, Markus   +8 more
core   +1 more source

RIPK3-Mediated Necroptosis and Neutrophil Infiltration Are Associated with Poor Prognosis in Patients with Alcoholic Cirrhosis

Journal of Immunology Research, 2018
Alcoholic cirrhosis is an end-stage liver disease with impaired survival and often requires liver transplantation. Recent data suggests that receptor-interacting protein kinase-3- (RIPK3-) mediated necroptosis plays an important role in alcoholic ...
Zhenzhen Zhang, Guomin Xie, Li Liang, Hui Liu, Jing Pan, Hao Cheng, Hua Wang, Aijuan Qu, Yan Wang   +8 more
doaj   +1 more source

Inhibition of Peptidyl Arginine Deiminase-4 Prevents Renal Ischemia-Reperfusion-Induced Remote Lung Injury

Mediators of Inflammation, 2020
Ischemia reperfusion (IR) can lead to acute kidney injury and can be complicated by acute lung injury, which is one of the leading causes of acute kidney injury-related death.
Mingjun Du, Lei Yang, Jianmin Gu, Jiawei Wu, Yiwen Ma, Tao Wang   +5 more
doaj   +1 more source